New strategies in drug discovery for GPCRs: High throughput detection of cellular ERK phosphorylation

Combinatorial Chemistry and High Throughput Screening

Volumn 11, Issue 5, 2008, Pages 344-356

  Crouch, Michael F ^a   Osmond, Ron I W ^a  

^a TGR BioSciences   (Australia)

Author keywords

Assay; ERK; G protein; GPCR; Homogeneous; HTS; Screening; SureFire

Indexed keywords

BETA ARRESTIN; CELL PROTEIN; CELL RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MULTIPROTEIN COMPLEX; PROTEIN TYROSINE KINASE;

ALLOSTERISM; ANTIGEN BINDING; DRUG MECHANISM; DRUG RESEARCH; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

BINDING SITES; DRUG DISCOVERY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; LIGANDS; PHOSPHORYLATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 45149121176     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620708784534806     Document Type: Review

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