The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism

Molecular Pharmacology

Volumn 71, Issue 6, 2007, Pages 1618-1629

  Van Der Westhuizen, Emma T ^a   Werry, Tim D ^a   Sexton, Patrick M ^a   Summers, Roger J ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RELAXIN;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL STIMULATION; CELL STRAIN HEK293; CHO CELL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME MECHANISM; HUMAN; HUMAN CELL; INTERNALIZATION; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; TRANSACTIVATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DIMERIZATION; ENZYME ACTIVATION; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C; PHOSPHORYLATION; PROTEIN KINASE C; RAF KINASES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RELAXIN; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 34347338779     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.032763     Document Type: Article

References (40)

1. Audet N, Paquin-Gobeil M, Landry-Paquet O, Schiller PW, and Piñeyro G (2005) Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands. J Biol Chem 280:7808-7816.
2. Balla S, Thapar V, Verma S, Luong T, Faghri T, Huang CH, Rajasekaran S, del Campo JJ, Shinn JH, Mohler WA, et al. (2006) Minimotif Miner: a tool for investigating protein function. Nat Methods 3:175-177.
3. Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, and Summers RJ (2006a) International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 58:7-31.
4. Bathgate RA, Samuel CS, Burazin TC, Layfield S, Claasz AA, Reytomas IG, Dawson NF, Zhao C, Bond C, Summers RJ, et al. (2002) Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J Biol Chem 277:1148-1157.
5. Bathgate RAD, Lin F, Hanson NF, Otvos L Jr, Guidolin A, Giannakis C, Bastiras S, Layfield S, Ferraro T, Ma S, et al. (2006b) Relaxin-3: improved synthesis strategy and demonstration of its high affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Biochemistry 45:1043-1053.
6. Berthoud HR (2004) Mind versus metabolism in the control of food intake and energy balance. Physiol Behav 81:781-793.
7. Bito H, Mori M, Sakanaka C, Takano T, Honda ZI, Gotoh Y, Nishida E, and Shimiau T (1994) Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. J Biol Chem 269:12722-12730.
8. Citro S, Ravasi S, Rovati GE, and Caproa V (2005) Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways. Am J Respir Cell Mol Biol 32:326-333.
9. Davies SP, Reddy H, Caivano M, and Cohen P (2000) Specificity and mechanism of some commonly used protein kinase inhibitors. Biochem J 351:95-105.
10. 1 receptor to phospholipase C in transfected CHO cells. Eur J Pharmacol 355:85-93.
11. Hansen SH, Sandvig K, and van Deurs B (1993) Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification. J Cell Biol 121:61-72.
12. 2+-MAPK/ERK pathways. J Neurochem 87:508-521.
13. Layden SS and Tregear GW (1996) Purification and characterization of porcine prorelaxin. J Biochem Biophys Methods 31:69-80.
14. Liu C, Eriste E, Sutton S, Chen J, Roland B, Kuei C, Farmer N, Jornvall H, Sillard R, and Lovenberg TW (2003) Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem 278:50754-50764.
15. Mannon PJ and Raymond JR (1998) The neuropeptide Y/peptide YY Y1 receptor is coupled to MAP kinase via PKC and ras in CHO cells. Biochem Biophys Res Commun 246:91-94.
16. Matsumoto M, Kamohara M, Sugimoto T, Hidaka K, Takasaki J, Saito T, Okada M, Yamaguchi T, and Furuichi K (2000) The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. Gene 248:183-189.
17. McGowan BM, Stanley SA, Smith KL, Minnion JS, Donovan J, Thompson EL, Patterson M, Connolly MM, Abbott CR, Small CJ, et al. (2006) Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats. Regul Pept 136:72-77.
18. McGowan BMC, Stanley SA, Smith KL, White NE, Connolly MM, Thompson EL, Gardiner JV, Murphy KG, Ghatei MA, and Bloom SR (2005) Central relaxin-3 administration causes hyperphagia in male Wistar rats. Endocrinology 146:3295-3300.
19. oalpha subunit isoforms. J Neurochem 73:622-640.
20. Morikawa Y, Ueyama E, and Senba E (2004) Fasting-induced activation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus. J Neuroendocrinol 16:105-112.
21. 2L receptor stimulation on the mitogen-activated protein kinase pathway is dependent on trans-activation of the platelet-derived growth factor receptor. Mol Pharmacol 60:92-103.
22. 1 and epidermal growth factor receptors. Mol Pharmacol 68:356-364.
23. Osmond RI, Sheehan A, Borowicz R, Barnett E, Harvey G, Turner C, Brown A, Crouch MF, and Dyer AR (2005) GPCR screening via ERK1/2: A novel platform for screening G protein-coupled receptors. J Biomol Screen 10:30-737.
24. Pierce KL, Tohgo A, Ahn S, Field ME, Luttrell LM, and Lefkowitz RJ (2001) Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: A co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. J Biol Chem 276:23155-23160.
25. Potter E, Sutton S, Donaldson C, Chen R, Perrin M, Lewis K, Sawchenko PE, and Vale W (1994) Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Proc Natl Acad Sci USA 91:8777-8781.
26. Robin P, Boulven I, Desmyther C, Harbon S, and Leiber D (2002) ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells. Am J Physiol 283:C251-C260.
27. Sammader P, Richards C, Bittman R, Bhullar RP, and Arthur G (2003) The antitumor ether lipid 1-Q-octadecyl-2-O-methyl-rac-glycerophosphocholine (ET-18-OCH3) inhibits the association between Ras and Raf-1. Anticancer Res 23:2291-2295.
28. Sasaguri K, Kikuchi M, Hori N, Yuyama N, Onozuka M, and Sato S (2005) Suppression of stress immobilization-induced phosphorylation of ERK1/2 by biting in the rat hypothalamic paraventricular nucleus. Neurosci Lett 383:160-164.
29. Shen CP, Tsimberg Y, Salvadore C, and Meller E (2004) Activation of ERK and JNK MAPK pathways by acute swim stress in rat brain regions. BMC Neurosci 5:36.
30. Shi W, Fan H, Shum L, and Derynck R (2000) The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation. J Cell Biol 148:591-602.
31. Sutton GM, Patterson LM, and Berthoud HR (2004a) Extracellular signal-regulated kinase 1/2 signalling pathway in solitary nucleus mediates cholycystokinin-induced suppression of food intake in rats. J Neurosci 24:10240-10247.
32. Sutton SW, Bonaventura P, Kuei C, Roland B, Chen J, Nepomuceno D, Lovenberg TW, and Liu C (2004b) Distribution of G-protein-coupled receptor (GPCR) 135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing. Neuroendocrinology 80:298-307.
33. Tanaka M, Iijima N, Miyamoto Y, Fukusumi S, Itoh Y, Ozawa H, and Ibata Y (2005) Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress. Eur J Neurosci 21:1659-1670.
34. Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, and Luttrell LM (2003) The stability of the G protein-coupled receptor-β-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem 278:6258-6267.
35. o-protein α-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. J Biol Chem 271:1266-1269.
36. van der Westhuizen ET, Sexton PM, Bathgate RA, and Summers RJ (2005) Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry. Ann NY Acad Sci 1041:332-337.
37. van Pett K, Viau V, Bittencourt JC, Chan RKW, Li HY, Arias C, Prins GS, Perrin M, Vale W, and Sawchenko PE (2000) Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol 428:191-212.
38. Werry TD, Gregory KJ, Sexton PM, and Christopoulos A (2005a) Characterization of serotonin 5-HT2C receptor signalling to extracellular signal-regulated kinases 1 and 2. J Neurochem 93:1603-1615.
39. Werry TD, Sexton PM, and Christopoulos A (2005b) 'Ins and outs' of seven-transmembrane receptor signalling to ERK. Trends Endocrinol Metab 16:26-33.
40. Young LT, Li PP, Siu KP, Kish SJ, and Warsh JJ (1993) Regional distribution of guanine nucleotide binding proteins (Gs and Gi alpha) in human brain: correlation with adenylyl cyclase activity. Neurochem Int 22:285-291.