Mechanism of inhibition of wt-dihydrofolate reductase from E. coli by tea epigallocatechin-gallate

Proteins: Structure, Function and Genetics

Volumn 72, Issue 1, 2008, Pages 240-251

  Spina, Michele ^a   Cuccioloni, Massimiliano ^a   Mozzicafreddo, Matteo ^a   Montecchia, Francesca ^a   Pucciarelli, Stefania ^a   Eleuteri, Anna Maria ^a   Fioretti, Evandro ^a   Angeletti, Mauro ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Bisubstrate inhibitor; DHFR; EGCG; Equilibrium study; Kinetics; Slow binding inhibitor

Indexed keywords

DIHYDROFOLATE REDUCTASE; EPIGALLOCATECHIN GALLATE; FOLIC ACID ANTAGONIST;

ANALYTIC METHOD; ARTICLE; BIOSENSOR; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; INHIBITION KINETICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; TEA; WILD TYPE;

ANIMALS; BIOSENSING TECHNIQUES; CATECHIN; CATTLE; ENZYMES, IMMOBILIZED; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; HUMANS; KINETICS; LIVER; MODELS, MOLECULAR; TEA; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); BOVINAE; MAMMALIA;

EID: 44949166602     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21914     Document Type: Article

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