Toxicity of non-aβ component of Alzheimer's disease amyloid, and N- terminal fragments thereof, correlates to formation of β-sheet structure and fibrils

European Journal of Biochemistry

Volumn 267, Issue 8, 2000, Pages 2186-2194

  Bodles, Angela M ^b   Guthrie, David J S ^b   Harriott, Patrick ^b   Campbell, Pamela ^b   Irvine, G Brent ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b NONE

Author keywords

synuclein; Alzheimer's disease; Amyloid; Circular dichroism; Neurotoxicity; Non A component of Alzheimer's disease amyloid

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; SYNTHETIC PEPTIDE; AMYLOID; NERVE PROTEIN; PEPTIDE FRAGMENT; SNCA PROTEIN, HUMAN; SNCA PROTEIN, RAT; SYNUCLEIN; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CIRCULAR DICHROISM; CYTOTOXICITY; DEMENTIA; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; PEPTIDE SYNTHESIS; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; SENILE PLAQUE; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; ELECTRON MICROSCOPY; HUMAN; METABOLISM; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION; PROTEIN SECONDARY STRUCTURE; SOLUBILITY; TIME; ULTRASTRUCTURE;

ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID; ANIMALS; CELL SURVIVAL; CIRCULAR DICHROISM; HUMANS; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OXIDATION-REDUCTION; PC12 CELLS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; RATS; SOLUBILITY; SYNUCLEINS; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS;

EID: 0034169203     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01219.x     Document Type: Article

References (30)

1. 1. El-Agnaf, O.M.A., Bodles, A.M., Guthrie, D.J.S., Harriott, P. & Irvine, G.B. (1998) The N-terminal region of non-Aβ component of Alzheimer's disease amyloid is responsible for its tendency to assume β-sheet and aggregate to form fibrils. Eur. J. Biochem. 258, 157-163.
2. 2. Glenner, G.C. & Wong, C.W. (1984) Alzheimer's disease: initial report of the purification and characterisation of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Comm. 120, 885-890.
3. 3. Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J.M., Masters, C.L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K. & Muller-Hill, B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
4. 4. Goldgaber, D., Lerman, M.I., McBride, O.W., Saffiotti, U. & Gajdusek, D.C. (1987) Characterisation and chromosomal localisation of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235, 877-880.
5. 5. Tanzi, R.E., Gusella, J.F., Watkins, P.C., Bruns, G.A.P., St George-Hyslop, P., Van Keuren, M.L., Patterson, D., Pagan, S., Kurnit, D.M. & Neve, R.L. (1987) Amyloid β protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus. Science 235, 880-884.
6. 6. Robakis, N.K., Ramakrishna, N., Wolfe, G. & Wisniewski, H.M. (1987) Molecular cloning and characterisation of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc. Natl Acad. Sci. USA 84, 4190-4194.
7. 7. Ueda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D.A.C., Kondo, J., Ihara, Y. & Saitoh, T. (1993) Molecular cloning of cDNA encoding an unrecognised component of amyloid in Alzheimer's disease. Proc. Natl Acad. Sci. USA 90, 11282-11286.
8. 8. Ueda, K., Saitoh, T. & Mori, H. (1994) Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-Aβ component of Alzheimer's disease amyloid. Biochem. Biophys. Res. Comm. 205, 1366-1372.
9. 9. Iwai, A., Yoshimoto, M., Masliah, E. & Saitoh, T. (1995) Non-Aβ component of Alzheimer's disease amyloid (NAC) is amyloidogenic. Biochemistry 34, 10139-10145.
10. 10. Han, H., Weinreb, P.H. & Lansbury, P.T. Jr (1995) The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by β-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chem. Biol. 2, 163-169.
11. 11. Jensen, P.H., Hojrup, P., Hager, H., Neilsen, M.S., Jacobsen, L., Olesen, O.F., Gliemann, J. & Jakes, R. (1997) Binding of Aβ to α-and β-synucleins: identification of segments in α-synuclein/NAC precursor that bind Aβ and NAC. Biochem. J. 323, 539-546.
12. 12. Olesen, O.F., Mikkelsen, J.D., Gerdes, C. & Jensen, P.H. (1997) Isoform-specific binding of human apolipoprotein E to the non-amyloid β component of Alzheimer's disease amyloid. Mol. Brain Res. 44, 105-112.
13. 13. Wakabayashi, K., Matsumoto, K., Takayama, K., Yoshimoto, M. & Takahashi, H. (1997) NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease. Neurosci. Lett. 239, 45-48.
14. 14. Spillantini, M.G., Schmidt, M.L., Lee, V.M.-Y., Trojanowski, J.G., Jakes, R. & Goedert, M. (1997) α-Synuclein in Lewy bodies. Nature 388, 839-840.
15. 15. Masliah, E., Iwai, A., Mallory, M., Ueda, K. & Saitoh, T. (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am. J. Pathol. 148, 201-210.
16. 16. Hsu, L.J., Mallory, M., Xia, Y., Veinbergs, I., Hashimoto, M., Yoshimoto, M., Thal, L.J., Saitoh, T. & Masliah, E. (1998) Expression pattern of synucleins (Non-Aβ component of Alzheimer's disease amyloid precursor protein/α-synuclein) during murine brain development. J. Neurochem. 71, 338-344.
17. 17. Takeda, A., Mallory, M., Sundsumo, M., Honer, W., Hansen, L. & Masliah, E. (1998) Abnormal accumulation of NACP/α-synuclein in neurodegenerative disorders. Am. J. Pathol. 152, 367-372.
18. 18. Goedert, M. (1997) The awakening of α-synuclein. Nature 388, 232-233.
19. 19. Polymeropoulos, M.H., Lavedan, C., Leroy, E., Ide, S.E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E.S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W.G., Lazzarini, A.M., Duvoisin, R.C., Dilorio, G., Golbe, L.I. & Nussbaum, R.L. (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
20. 20. El-Agnaf, O.M.A., Jakes, R., Curran, M.D. & Wallace, A. (1998) Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease. FEBS Lett. 440, 67-70.
21. 21. Conway, K.A., Harper, J.D. & Lansbury, P.T. (1998) Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson's disease. Nature Med. 4, 1318-1320.
22. 22. El-Agnaf, O.M.A., Jakes, R., Curran, M.D., Middleton, D., Ingenito, R., Bianchi, E., Pessi, A., Neill, D. & Wallace, A. (1998) Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like fibrils. FEBS Lett. 440, 71-75.
23. 23. Simmons, L.K., May, P.C., Tomaselli, K.J., Rydel, R.E., Fuson, K.S., Brigham, E.F., Wright, S., Lieberburg, I., Becker, G.W., Brems, D.N. & Li, W.Y. (1994) Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro. Mol. Pharmacol. 45, 373-379.
24. 24. Lorenzo, A. & Yankner, B.A. (1994) β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl Acad. Sci. USA 91, 12243-12247.
25. 25. Shearman, M.S., Ragan, C.I. & Iversen, L.L. (1994) Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death. Proc. Natl Acad. Sci. USA 91, 1470-1474.
26. 26. Shearman, M.S., Hawtin, S.R. & Tailor, V.J. (1995) The intracellular component of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by β-amyloid peptides. J. Neurochem. 65, 218-227.
27. 27. Buchet, R., Tavitian, E., Ristig, D., Swoboda, R., Stauss, U., Gremlich, H.U., de La Fourniere, L., Staufenbiel, M., Frey, P. & Lowe, D.A. (1996) Conformations of synthetic β peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells. Biochim. Biophys. Acta 1315, 40-46.
28. 28. Walsh, D.M., Hartley, D.M., Kusumoto, Y., Fezoui, Y., Condron, M.M., Lomakin, A., Benedek, G.B., Selkoe, D.J. & Teplow, D.B. (1999) Amyloid β-protein fibrillogenesis: structure and biological activity of protofibrillar intermediates. J. Biol. Chem. 274, 25945-25952.
29. 29. Harper, J.D., Wong, S.S., Lieber, C.M. & Lansbury, P.T. Jr (1999) Assembly of Aβ amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease. Biochemistry 38, 8972-8980.
30. 30. Lansbury, P.T. Jr (1999) Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease. Proc. Natl Acad. Sci. USA 96, 3342-3344.