Neuropeptide Y signalling on hippocampal stem cells in health and disease

Molecular and Cellular Endocrinology

Volumn 288, Issue 1-2, 2008, Pages 52-62

  Gray, William P ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Hippocampus; Interneuron; Learning and memory; Mood; Neurogenesis; NPY; Stem cell

Indexed keywords

BETA TUBULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NESTIN; NEUROPEPTIDE Y;

CELL PROLIFERATION; COGNITION; DENTATE GYRUS; HIPPOCAMPUS; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEIZURE; SIGNAL TRANSDUCTION; STEM CELL; TEMPORAL LOBE EPILEPSY;

ANIMALS; DISEASE; HEALTH; HIPPOCAMPUS; HUMANS; NEUROPEPTIDE Y; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 44649161131     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.02.021     Document Type: Review

References (158)

1. Abrous D.N., Koehl M., and Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiol. Rev. 85 (2005) 523-569
2. Albers H.E., and Ferris C.F. Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms. Neurosci. Lett. 50 (1984) 163-168
3. Albers H.E., Ferris C.F., Leeman S.E., and Goldman B.D. Avian pancreatic polypeptide phase shifts hamster circadian rhythms when microinjected into the suprachiasmatic region. Science 223 (1984) 833-835
4. Altar C.A., Laeng P., Jurata L.W., Brockman J.A., Lemire A., Bullard J., Bukhman Y.V., Young T.A., Charles V., and Palfreyman M.G. Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways. J. Neurosci. 24 (2004) 2667-2677
5. Altman J., and Das G.D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol. 124 (1965) 319-335
6. Altman J., and Bayer S.A. Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods. J. Comp. Neurol. 301 (1990) 365-381
7. Bengzon J., Kokaia Z., Elmer E., Nanobashvili A., Kokaia M., and Lindvall O. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc. Natl. Acad. Sci. USA 94 (1997) 10432-10437
8. Bjornebekk A., Mathe A.A., and Brene S. Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls. Neuropsychopharmacology 31 (2006) 256-264
9. Bouchard P., Maurice T., St-Pierre S., Privat A., and Quirion R. Neuropeptide Y and the calcitonin gene-related peptide attenuate learning impairments induced by MK-801 via a sigma receptor-related mechanism. Eur. J. Neurosci. 9 (1997) 2142-2151
10. Brezun J.M., and Daszuta A. Serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons. Eur. J. Neurosci. 12 (2000) 391-396
11. Butovsky O., Talpalar A.E., Ben-Yaakov K., and Schwartz M. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol. Cell Neurosci. 29 (2005) 381-393
12. Butovsky O., Ziv Y., Schwartz A., Landa G., Talpalar A.E., Pluchino S., Martino G., and Schwartz M. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell Neurosci. 31 (2006) 149-160
13. Caberlotto L., Jimenez P., Overstreet D.H., Hurd Y.L., Mathe A.A., and Fuxe K. Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression. Neurosci. Lett. 265 (1999) 191-194
14. Cameron H.A., and Gould E. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience 61 (1994) 203-209
15. Cameron H.A., and McKay R.D. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 435 (2001) 406-417
16. Cameron H.A., McEwen B.S., and Gould E. Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J. Neurosci. 15 (1995) 4687-4692
17. Carvajal C.C., Vercauteren F., Dumont Y., Michalkiewicz M., and Quirion R. Aged neuropeptide Y transgenic rats are resistant to acute stress but maintain spatial and non-spatial learning. Behav. Brain Res. 153 (2004) 471-480
18. Causing C.G., Makus K.D., Ma Y., Miller F.D., and Colmers W.F. Selective upregulation of T alpha 1 alpha-tubulin and neuropeptide Y mRNAs after intermittent excitatory stimulation in adult rat hippocampus in vivo. J. Comp. Neurol. 367 (1996) 132-146
19. Chen G., Rajkowska G., Du F., Seraji-Bozorgzad N., and Manji H.K. Enhancement of hippocampal neurogenesis by lithium. J. Neurochem. 75 (2000) 1729-1734
20. Ciaroni S., Cecchini T., Ferri P., Ambrogini P., Cuppini R., Riccio M., Lombardelli G., Papa S., and Del Grande P. Impairment of neural precursor proliferation increases survival of cell progeny in the adult rat dentate gyrus. Mech. Ageing Dev. 123 (2002) 1341-1352
21. Colmers W.F., and Bleakman D. Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. 17 (1994) 373-379
22. Covolan L., Ribeiro L.T., Longo B.M., and Mello L.E. Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus. Hippocampus 10 (2000) 169-180
23. Curtis M.A., Kam M., Nannmark U., Anderson M.F., Axell M.Z., Wikkelso C., Holtas S., van Roon-Mom W.M., Bjork-Eriksson T., Nordborg C., Frisen J., Dragunow M., Faull R.L., and Eriksson P.S. Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science 315 (2007) 1243-1249
24. de Bono M., and Bargmann C.I. Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. Cell 94 (1998) 679-689
25. Deisseroth K., Singla S., Toda H., Monje M., Palmer T.D., and Malenka R.C. Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron 42 (2004) 535-552
26. Deller T., and Leranth C. Synaptic connections of neuropeptide Y (NPY) immunoreactive neurons in the hilar area of the rat hippocampus. J. Comp. Neurol. 300 (1990) 433-447
27. Doetsch F., Caille I., Lim D.A., Garcia-Verdugo J.M., and Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97 (1999) 703-716
28. Drapeau E., Mayo W., Aurousseau C., Le Moal M., Piazza P.V., and Abrous D.N. Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis. Proc. Natl. Acad. Sci. USA 100 (2003) 14385-14390
29. D'Sa C., and Duman R.S. Antidepressants and neuroplasticity. Bipolar Disord. 4 (2002) 183-194
30. Eichenbaum H. Declarative memory: insights from cognitive neurobiology. Annu. Rev. Psychol. 48 (1997) 547-572
31. Ekdahl C.T., Claasen J.H., Bonde S., Kokaia Z., and Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc. Natl. Acad. Sci. USA 100 (2003) 13632-13637
32. Erickson J.C., Clegg K.E., and Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381 (1996) 415-421
33. Eriksson P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A., and Gage F.H. Neurogenesis in the adult human hippocampus. Nat. Med. 4 (1998) 1313-1317
34. Fabry M., Langer M., Rothen-Rutishauser B., Wunderli-Allenspach H., Hocker H., and Beck-Sickinger A.G. Monitoring of the internalization of neuropeptide Y on neuroblastoma cell line SK-N-MC. Eur. J. Biochem. 267 (2000) 5631-5637
35. Ferland R.J., Gross R.A., and Applegate C.D. Increased mitotic activity in the dentate gyrus of the hippocampus of adult C57BL/6J mice exposed to the flurothyl kindling model of epileptogenesis. Neuroscience 115 (2002) 669-683
36. Flood J.F., and Morley J.E. Dissociation of the effects of neuropeptide Y on feeding and memory: evidence for pre- and postsynaptic mediation. Peptides 10 (1989) 963-966
37. Flood J.F., Hernandez E.N., and Morley J.E. Modulation of memory processing by neuropeptide Y. Brain Res. 421 (1987) 280-290
38. Freund T.F., and Buzsaki G. Interneurons of the hippocampus. Hippocampus 6 (1996) 347-470
39. Gage F.H. Neurogenesis in the adult brain. J. Neurosci. 22 (2002) 612-613
40. Ge S., Goh E.L., Sailor K.A., Kitabatake Y., Ming G.L., and Song H. GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439 (2006) 589-593
41. Ge S., Pradhan D.A., Ming G.L., and Song H. GABA sets the tempo for activity-dependent adult neurogenesis. Trends Neurosci. 30 (2007) 1-8
42. Gould E., McEwen B.S., Tanapat P., Galea L.A., and Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J. Neurosci. 17 (1997) 2492-2498
43. Gould E., Beylin A., Tanapat P., Reeves A., and Shors T.J. Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 2 (1999) 260-265
44. Gray W.P., and Sundstrom L.E. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res. 790 (1998) 52-59
45. Gruber B., Greber S., Rupp E., and Sperk G. Differential NPY mRNA expression in granule cells and interneurons of the rat dentate gyrus after kainic acid injection. Hippocampus 4 (1994) 474-482
46. Hack M.A., Saghatelyan A., de Chevigny A., Pfeifer A., Ashery-Padan R., Lledo P.M., and Gotz M. Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat. Neurosci. 8 (2005) 865-872
47. Hansel D.E., Eipper B.A., and Ronnett G.V. Neuropeptide Y functions as a neuroproliferative factor. Nature 410 (2001) 940-944
48. Hansel D.E., Eipper B.A., and Ronnett G.V. Regulation of olfactory neurogenesis by amidated neuropeptides. J. Neurosci. Res. 66 (2001) 1-7
49. Hastings N.B., and Gould E. Rapid extension of axons into the CA3 region by adult-generated granule cells. J. Comp. Neurol. 413 (1999) 146-154
50. Heilig M. The NPY system in stress, anxiety and depression. Neuropeptides 38 (2004) 213-224
51. Heilig M., Wahlestedt C., Ekman R., and Widerlov E. Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain. Eur. J. Pharmacol. 147 (1988) 465-467
52. Heilig M., Soderpalm B., Engel J.A., and Widerlov E. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology (Berl) 98 (1989) 524-529
53. Higuchi H., Yang H.Y., and Costa E. Age-related bidirectional changes in neuropeptide Y peptides in rat adrenal glands, brain, and blood. J. Neurochem. 50 (1988) 1879-1886
54. Hokfelt T., Johansson O., and Goldstein M. Chemical anatomy of the brain. Science 225 (1984) 1326-1334
55. Howell O.W., Scharfman H.E., Herzog H., Sundstrom L.E., Beck-Sickinger A., and Gray W.P. Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J. Neurochem. 86 (2003) 646-659
56. Howell O.W., Doyle K., Goodman J.H., Scharfman H.E., Herzog H., Pringle A., Beck-Sickinger A.G., and Gray W.P. Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. J. Neurochem. 93 (2005) 560-570
57. Howell O.W., Silva S., Scharfman H.E., Sosunov A.A., Zaben M., Shatya A., McKhann II G., Herzog H., Laskowski A., and Gray W.P. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiol. Dis. 26 (2007) 174-188
58. Husum H., and Mathe A.A. Early life stress changes concentrations of neuropeptide Y and corticotropin-releasing hormone in adult rat brain Lithium treatment modifies these changes. Neuropsychopharmacology 27 (2002) 756-764
59. Husum H., Mikkelsen J.D., Hogg S., Mathe A.A., and Mork A. Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram. Neuropharmacology 39 (2000) 1463-1473
60. Huttmann K., Sadgrove M., Wallraff A., Hinterkeuser S., Kirchhoff F., Steinhauser C., and Gray W.P. Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. Eur. J. Neurosci. 18 (2003) 2769-2778
61. Jacobs B.L., Praag H., and Gage F.H. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol. Psychiatry 5 (2000) 262-269
62. Jessberger S., Romer B., Babu H., and Kempermann G. Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells. Exp. Neurol. 196 (2005) 342-351
63. Jessberger S., Zhao C., Toni N., Clemenson Jr. G.D., Li Y., and Gage F.H. Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J. Neurosci. 27 (2007) 9400-9407
64. Jiang W., Wan Q., Zhang Z.J., Wang W.D., Huang Y.G., Rao Z.R., and Zhang X. Dentate granule cell neurogenesis after seizures induced by pentylenetrazol in rats. Brain Res. 977 (2003) 141-148
65. Kalra S.P., and Kalra P.S. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38 (2004) 201-211
66. Karishma K.K., and Herbert J. Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression. Eur. J. Neurosci. 16 (2002) 445-453
67. Karlsson R.M., Choe J.S., Cameron H.A., Thorsell A., Crawley J.N., Holmes A., and Heilig M. The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice. Psychopharmacology (Berl) (2007)
68. Kastin A.J., and Akerstrom V. Nonsaturable entry of neuropeptide Y into brain. Am. J. Physiol. 276 (1999) E479-E482
69. Kempermann G., Kuhn H.G., and Gage F.H. More hippocampal neurons in adult mice living in an enriched environment. Nature 386 (1997) 493-495
70. Kempermann G., Jessberger S., Steiner B., and Kronenberg G. Milestones of neuronal development in the adult hippocampus. Trends Neurosci. 27 (2004) 447-452
71. Kohler C., Eriksson L., Davies S., and Chan-Palay V. Neuropeptide Y innervation of the hippocampal region in the rat and monkey brain. J. Comp. Neurol. 244 (1986) 384-400
72. Kopp J., Xu Z.Q., Zhang X., Pedrazzini T., Herzog H., Kresse A., Wong H., Walsh J.H., and Hokfelt T. Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice focus on immunohistochemical localization. Neuroscience 111 (2002) 443-532
73. Kopp J., Xu Z.Q., Zhang X., Pedrazzini T., Herzog H., Kresse A., Wong H., Walsh J.H., and Hokfelt T. Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice focus on immunohistochemical localization (1). Neuroscience 111 (2002) 443-532
74. Krsmanovic L.Z., Stojilkovic S.S., Mertz L.M., Tomic M., and Catt K.J. Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc. Natl. Acad. Sci. USA 90 (1993) 3908-3912
75. Larhammar D. Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide. Regul. Pept. 62 (1996) 1-11
76. Laskowski A., Howell O.W., Sosunov A.A., McKhann G., and Gray W.P. NPY mediates basal and seizure-induced proliferation in the subcallosal zone. Neuroreport 18 (2007) 1005-1008
77. Lemaire V., Koehl M., Le Moal M., and Abrous D.N. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc. Natl. Acad. Sci. USA 97 (2000) 11032-11037
78. Lendahl U., Zimmerman L.B., and McKay R.D. CNS stem cells express a new class of intermediate filament protein. Cell 60 (1990) 585-595
79. Levison S.W., and Goldman J.E. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain. Neuron 10 (1993) 201-212
80. Levison S.W., Young G.M., and Goldman J.E. Cycling cells in the adult rat neocortex preferentially generate oligodendroglia. J. Neurosci. Res. 57 (1999) 435-446
81. Li B.S., Ma W., Zhang L., Barker J.L., Stenger D.A., and Pant H.C. Activation of phosphatidylinositol-3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells. J. Neurosci. 21 (2001) 1569-1579
82. Liu X., Wang Q., Haydar T.F., and Bordey A. Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nat. Neurosci. 8 (2005) 1179-1187
83. Lois C., and Alvarez-Buylla A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc. Natl. Acad. Sci. USA 90 (1993) 2074-2077
84. Lopez-Ilasaca M. Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades. Biochem. Pharmacol. 56 (1998) 269-277
85. Lundberg J.M., Martinsson A., Hemsen A., Theodorsson-Norheim E., Svedenhag J., Ekblom B., and Hjemdahl P. Co-release of neuropeptide Y and catecholamines during physical exercise in man. Biochem. Biophys. Res. Commun. 133 (1985) 30-36
86. Madsen T.M., Treschow A., Bengzon J., Bolwig T.G., Lindvall O., and Tingstrom A. Increased neurogenesis in a model of electroconvulsive therapy. Biol. Psychiatry 47 (2000) 1043-1049
87. Malberg J.E., Eisch A.J., Nestler E.J., and Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20 (2000) 9104-9110
88. Markakis E.A., and Gage F.H. Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J. Comp. Neurol. 406 (1999) 449-460
89. Marksteiner J., Sperk G., and Maas D. Differential increases in brain levels of neuropeptide Y and vasoactive intestinal polypeptide after kainic acid-induced seizures in the rat. Naunyn. Schmiedebergs Arch. Pharmacol. 339 (1989) 173-177
90. Marksteiner J., Ortler M., Bellman R., and Sperk G. Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat. Neurosci. Lett. 112 (1990) 143-148
91. Mazarati A., Lu X., Kilk K., Langel U., Wasterlain C., and Bartfai T. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur. J. Neurosci. 19 (2004) 3235-3244
92. McCarthy J.B., Walker M., Pierce J., Camp P., and White J.D. Biosynthesis and metabolism of native and oxidized neuropeptide Y in the hippocampal mossy fiber system. J. Neurochem. (1998) 1950-1963
93. Menn B., Garcia-Verdugo J.M., Yaschine C., Gonzalez-Perez O., Rowitch D., and Alvarez-Buylla A. Origin of oligodendrocytes in the subventricular zone of the adult brain. J. Neurosci. 26 (2006) 7907-7918
94. Merkle F.T., Mirzadeh Z., and Alvarez-Buylla A. Mosaic organization of neural stem cells in the adult brain. Science 317 (2007) 381-384
95. Mikkelsen J.D., Woldbye D., Kragh J., Larsen P.J., and Bolwig T.G. Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus. Brain Res. Mol. Brain Res. 23 (1994) 317-322
96. Milner T.A., and Veznedaroglu E. Ultrastructural localization of neuropeptide Y-like immunoreactivity in the rat hippocampal formation. Hippocampus 2 (1992) 107-126
97. Mitchell J., Cook I., and Hervey V. Effect of seizures on hippocampal peptidergic neurons. Neuropathol. Appl. Neurobiol. 23 (1997) 299-306
98. Modigh K. Long-term effects of electroconvulsive shock therapy on synthesis, turnover and uptake of brain monoamines. Psychopharmacology (Berl) 49 (1976) 179-185
99. Mohapel P., Leanza G., Kokaia M., and Lindvall O. Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol. Aging 26 (2005) 939-946
100. Monje M.L., Toda H., and Palmer T.D. Inflammatory blockade restores adult hippocampal neurogenesis. Science 302 (2003) 1760-1765
101. Morgan III C.A., Wang S., Southwick S.M., Rasmusson A., Hazlett G., Hauger R.L., and Charney D.S. Plasma neuropeptide-Y concentrations in humans exposed to military survival training. Biol. Psychiatry 47 (2000) 902-909
102. Morgan III C.A., Rasmusson A.M., Wang S., Hoyt G., Hauger R.L., and Hazlett G. Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: replication and extension of previous report. Biol. Psychiatry 52 (2002) 136-142
103. Nakagawa E., Aimi Y., Yasuhara O., Tooyama I., Shimada M., McGeer P.L., and Kimura H. Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy. Epilepsia 41 (2000) 10-18
104. O'Kusky J.R., Ye P., and D'Ercole A.J. Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development. J. Neurosci. 20 (2000) 8435-8442
105. Overstreet Wadiche L., Bromberg D.A., Bensen A.L., and Westbrook G.L. GABAergic signaling to newborn neurons in dentate gyrus. J. neurophysiol. 94 (2005) 4528-4532
106. Overstreet-Wadiche L.S., Bromberg D.A., Bensen A.L., and Westbrook G.L. Seizures accelerate functional integration of adult-generated granule cells. J. Neurosci. 26 (2006) 4095-4103
107. Palmer T.D., Takahashi J., and Gage F.H. The adult rat hippocampus contains primordial neural stem cells. Mol. Cell Neurosci. 8 (1997) 389-404
108. Parent J.M. The role of seizure-induced neurogenesis in epileptogenesis and brain repair. Epilepsy Res. 50 (2002) 179-189
109. Parent J.M., Yu T.W., Leibowitz R.T., Geschwind D.H., Sloviter R.S., and Lowenstein D.H. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 17 (1997) 3727-3738
110. Parent J.M., Valentin V.V., and Lowenstein D.H. Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway. J. Neurosci. 22 (2002) 3174-3188
111. Parent J.M., Elliott R.C., Pleasure S.J., Barbaro N.M., and Lowenstein D.H. Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy. Ann. Neurol. 59 (2006) 81-91
112. Parker R.M.C., and Herzog H. Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur. J. Neurosci. 11 (1999) 1431-1448
113. Pedrazzini T., Seydoux J., Kunstner P., Aubert J.F., Grouzmann E., Beermann F., and Brunner H.R. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat. Med. 4 (1998) 722-726
114. Pernow J., Lundberg J.M., Kaijser L., Hjemdahl P., Theodorsson-Norheim E., Martinsson A., and Pernow B. Plasma neuropeptide Y-like immunoreactivity and catecholamines during various degrees of sympathetic activation in man. Clin. Physiol. 6 (1986) 561-578
115. Pickel V.M., Chan J., Veznedaroglu E., and Milner T.A. Neuropeptide Y and dynorphin-immunoreactive large dense-core vesicles are strategically localized for presynaptic modulation in the hippocampal formation and substantia nigra. Synapse 19 (1995) 160-169
116. Prickaerts J., Koopmans G., Blokland A., and Scheepens A. Learning and adult neurogenesis: survival with or without proliferation?. Neurobiol. Learn. Mem. 81 (2004) 1-11
117. Radley J.J., and Jacobs B.L. Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism. Brain Res. 966 (2003) 1-12
118. Redrobe J.P., Dumont Y., St-Pierre J.A., and Quirion R. Multiple receptors for neuropeptide Y in the hippocampus: putative roles in seizures and cognition. Brain Res. 848 (1999) 153-166
119. Redrobe J.P., Dumont Y., Fournier A., and Quirion R. The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology 26 (2002) 615-624
120. Redrobe J.P., Dumont Y., Herzog H., and Quirion R. Characterization of neuropeptide Y Y(2) receptor knockout mice in two animal models of learning and memory processing. J. Mol. Neurosci. 22 (2004) 159-166
121. Sajdyk T.J., Vandergriff M.G., and Gehlert D.R. Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur. J. Pharmacol. 368 (1999) 143-147
122. Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., Weisstaub N., Lee J., Duman R., Arancio O., Belzung C., and Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301 (2003) 805-809
123. Scharfman H.E., and Gray W.P. Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis. Exs (2006) 193-211
124. Scharfman H.E., Goodman J.H., and Sollas A.L. Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis. J. Neurosci. 20 (2000) 6144-6158
125. Schlessinger A.R., Cowan W.M., and Gottlieb D.I. An autoradiographic study of the time of origin and the pattern of granule cell migration in the dentate gyrus of the rat. J. Comp. Neurol. 159 (1975) 149-175
126. Seaberg R.M., and van der Kooy D. Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J. Neurosci. 22 (2002) 1784-1793
127. Seki T., and Arai Y. Temporal and spacial relationships between PSA-NCAM-expressing, newly generated granule cells, and radial glia-like cells in the adult dentate gyrus. J. Comp. Neurol. 410 (1999) 503-513
128. Seri B., Garcia-Verdugo J.M., McEwen B.S., and Alvarez-Buylla A. Astrocytes give rise to new neurons in the adult mammalian hippocampus. J. Neurosci. 21 (2001) 7153-7160
129. Seri B., Garcia-Verdugo J.M., Collado-Morente L., McEwen B.S., and Alvarez-Buylla A. Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus. J. Comp. Neurol. 478 (2004) 359-378
130. Seri B., Herrera D.G., Gritti A., Ferron S., Collado L., Vescovi A., Garcia-Verdugo J.M., and Alvarez-Buylla A. Composition and organization of the SCZ: a large germinal layer containing neural stem cells in the adult mammalian brain. Cereb. Cortex 16 Suppl. 1 (2006) i103-i111
131. Shapiro L.A., Korn M.J., Shan Z., and Ribak C.E. GFAP-expressing radial glia-like cell bodies are involved in a one-to-one relationship with doublecortin-immunolabeled newborn neurons in the adult dentate gyrus. Brain Res. 1040 (2005) 81-91
132. Shors T.J. Memory traces of trace memories: neurogenesis, synaptogenesis and awareness. Trends Neurosci. 27 (2004) 250-256
133. Shors T.J., Miesegaes G., Beylin A., Zhao M., Rydel T., and Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature 410 (2001) 372-376
134. Snyder J.S., Kee N., and Wojtowicz J.M. Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J. Neurophysiol. 85 (2001) 2423-2431
135. Sokolowski M.B. NPY and the regulation of behavioral development. Neuron 39 (2003) 6-8
136. Sperk G., Marksteiner J., Gurber B., Bellmann R., Mahata M., and Ortler M. Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat. Neuroscience 50 (1992) 831-846
137. Thiele T.E., Sparta D.R., Hayes D.M., and Fee J.R. A role for neuropeptide Y in neurobiological responses to ethanol and drugs of abuse. Neuropeptides 38 (2004) 235-243
138. Thorsell A., Michalkiewicz M., Dumont Y., Quirion R., Caberlotto L., Rimondini R., Mathe A.A., and Heilig M. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proc. Natl. Acad. Sci USA 97 (2000) 12852-12857
139. Tozuka Y., Fukuda S., Namba T., Seki T., and Hisatsune T. GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells. Neuron. 47 (2005) 803-815
140. Ubink R., Calza L., and Hokfelt T. Neuro-peptides in glia: focus on NPY and galanin. Trends Neurosci. 26 (2003) 604-609
141. Vallieres L., Campbell I.L., Gage F.H., and Sawchenko P.E. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J. Neurosci. 22 (2002) 486-492
142. Van der Borght K., Mulder J., Keijser J.N., Eggen B.J., Luiten P.G., and Van der Zee E.A. Input from the medial septum regulates adult hippocampal neurogenesis. Brain Res. Bull. 67 (2005) 117-125
143. van Praag H., Kempermann G., and Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2 (1999) 266-270
144. van Praag H., Schinder A.F., Christie B.R., Toni N., Palmer T.D., and Gage F.H. Functional neurogenesis in the adult hippocampus. Nature 415 (2002) 1030-1034
145. Vezzani A., and Sperk G. Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy?. Neuropeptides 38 (2004) 245-252
146. Vezzani A., Monhemius R., Tutka P., Milani R., and Samanin R. Functional activation of somatostatin- and neuropeptide Y-containing neurons in the entorhinal cortex of chronically epileptic rats. Neuroscience 75 (1996) 551-557
147. Vezzani A., Ravizza T., Moneta D., Conti M., Borroni A., Rizzi M., Samanin R., and Maj R. Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsons: temporal evolution of changes as compared to neuropeptide Y. Neuroscience 90 (1999) 1445-1461
148. Vezzani A., Sperk G., and Colmers W.F. Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 22 (1999) 25-30
149. Wahlestedt C., Pich E.M., Koob G.F., Yee F., and Heilig M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259 (1993) 528-531
150. Wang D.D., Krueger D.D., and Bordey A. GABA depolarizes neuronal progenitors of the postnatal subventricular zone via GABAA receptor activation. J. physiol. 550 (2003) 785-800
151. Wang L.P., Kempermann G., and Kettenmann H. A subpopulation of precursor cells in the mouse dentate gyrus receives synaptic GABAergic input. Mol. Cell Neurosci. 29 (2005) 181-189
152. Waschek J.A., Lelievre V., Bravo D.T., Nguyen T., and Muller J.M. Retinoic acid regulation of the VIP and PACAP autocrine ligand and receptor system in human neuroblastoma cell lines. Peptides 18 (1997) 835-841
153. Westrin A., Ekman R., and Traskman-Bendz L. Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt. Eur. Neuropsychopharmacol. 9 (1999) 205-211
154. Wettstein J.G., Earley B., and Junien J.L. Central nervous system pharmacology of neuropeptide Y. Pharmacol. Therapeut. 65 (1995) 397-414
155. Wu Q., Wen T., Lee G., Park J.H., Cai H.N., and Shen P. Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system. Neuron 39 (2003) 147-161
156. Xu Z.Q., Shi T.J., and Hokfelt T. Galanin/GMAP- and NPY-like immunoreactivities in locus coeruleus and noradrenergic nerve terminals in the hippocampal formation and cortex with notes on the galanin-R1 and -R2 receptors. J. Comp. Neurol. 392 (1998) 227-251
157. Yoshimura S., Takagi Y., Harada J., Teramoto T., Thomas S.S., Waeber C., Bakowska J.C., Breakefield X.O., and Moskowitz M.A. FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc. Natl. Acad. Sci. USA 98 (2001) 5874-5879
158. Ziv Y., Ron N., Butovsky O., Landa G., Sudai E., Greenberg N., Cohen H., Kipnis J., and Schwartz M. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat. Neurosci. 9 (2006) 268-275