Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 12, 2008, Pages 6423-6435

  Bey, Emmanuel ^a   Marchais Oberwinkler, Sandrine ^a   Kruchten, Patricia ^a   Frotscher, Martin ^a   Werth, Ruth ^a   Oster, Alexander ^a   Algül, Oztekin ^a   Neugebauer, Alexander ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

17 HSD1; 17 HSD2; Bis(hydroxyphenyl) azoles; ER; Estrogen dependent diseases; Non steroidal inhibitor

Indexed keywords

17ALPHA ESTRADIOL; 3 [5 (4 HYDROXYPHENYL) 1,3 OXAZOL 2 YL]PHENOL; BIS(HYDROXYPHENYL)AZOLE; ESTRADIOL; PYRROLE DERIVATIVE; TESTOSTERONE 17BETA DEHYDROGENASE;

ARTICLE; BREAST TUMOR; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR MODEL;

17-HYDROXYSTEROID DEHYDROGENASES; ANTINEOPLASTIC AGENTS, HORMONAL; AZOLES; BREAST NEOPLASMS; CACO-2 CELLS; DRUG DESIGN; ENZYME INHIBITORS; ESTROGEN ANTAGONISTS; ESTROGENS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PERMEABILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44649139243     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.073     Document Type: Article

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