Distinct MAPK signaling pathways, p21 up-regulation and caspase-mediated p21 cleavage establishes the fate of U937 cells exposed to 3-hydrogenkwadaphnin: Differentiation versus apoptosis

Toxicology and Applied Pharmacology

Volumn 230, Issue 1, 2008, Pages 86-96

  Moosavi, Mohammad Amin ^a   Yazdanparast, Razieh ^a  

^a UNIVERSITY OF TEHRAN   (Iran)

Author keywords

3 hydrogenkwadaphnin; Apoptosis; Caspase; Differentiation; Leukemia; MAP kinase; p21Cip WAF1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 HYDROGENKWADAPHNIN; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; CASPASE 8; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; P21 ACTIVATED KINASE; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE 1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL POPULATION; CELL STRAIN U937; CELL SUSPENSION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; MACROPHAGE; MITOCHONDRION; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASES; CELL CYCLE; CELL DIFFERENTIATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DITERPENES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; SIGNAL TRANSDUCTION; U937 CELLS; UP-REGULATION;

EID: 44649111748     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.02.010     Document Type: Article

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