Low magnesium promotes endothelial cell dysfunction: Implications for atherosclerosis, inflammation and thrombosis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1689, Issue 1, 2004, Pages 13-21

  Maier, Jeanette A M ^a   Malpuech Brugère, Corinne ^b   Zimowska, Wioletta ^b   Rayssiguier, Yves ^b   Mazur, Andrzej ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b CRNH AUVERGNE   (France)

Author keywords

Atherosclerosis; Endothelial cell; Gene expression; Inflammation; Magnesium

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CATION; CD9 ANTIGEN; CELL CYCLE PROTEIN; COMPLEMENTARY DNA; CYTOHESIN 1; EZRIN; INTERLEUKIN 1; MAGNESIUM; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN TYROSINE KINASE; VASCULAR CELL ADHESION MOLECULE 1; ZYXIN;

ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CELL ADHESION; CELL FUNCTION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DNA MICROARRAY; DOWN REGULATION; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; MAGNESIUM DEFICIENCY; ONCOGENE SRC; PRIORITY JOURNAL; THROMBOSIS; UPREGULATION; VASCULAR ENDOTHELIUM;

ARTERIOSCLEROSIS; CDC25 PHOSPHATASE; CELL ADHESION; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELL MOVEMENT; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-1; MAGNESIUM; MAGNESIUM DEFICIENCY; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTO-ONCOGENE PROTEINS PP60(C-SRC); THROMBOSIS;

EID: 2442711141     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2004.01.002     Document Type: Article

References (41)

1. Cines D.B., Pollak E.S., Buck C.A., Loscalzo J., Zimmerman G.A., McEver R.P., Pober J.S., Wick T.M., Konkle B.A., Schwartz B.S., Barnathan E.S., McCrae K.R., Hug B.A., Schmidt A.M., Stern D.M. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 91:1998;3527-3561
2. Ross R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340:1999;115-126
3. Lifton R.P., Gharavi A.G., Geller D.S. Molecular mechanisms of human hypertension. Cell. 104:2001;545-556
4. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1:1995;27-31
5. Seelig M.S. Epidemiologic data on magnesium-deficiency associated cardiovascular disease and osteoporosis: consideration of risk of current recommendations for high calcium intakes. Rayssiguier Y., Mazur A., Durlach J. Advances in Magnesium Research. Nutrition and Health. 2001;177-190 J. Libbey, London
6. Peacock J.M., Folsom A.R., Arnett D.K., Eckfeldt J.H., Szklo M. Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study. Ann. Epidemiol. 9:1999;159-165
7. Liao F., Folsom A.R., Brancati F.L. Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study. Am. Heart J. 136:1998;480-490
8. Mussoni L., Sironi L., Tedeschi L., Calvio A.M., Colli S., Tremoli E. Magnesium inhibits arterial thrombi after vascular injury in rat: in vivo impairment of coagulation. Thromb. Haemost. 86:2001;1292-1295
9. Barbagallo M., Dominguez L.J., Resnick L.M. Insulin-mimetic action of vanadate: role of intracellular magnesium. Hypertension. 38:2001;701-704
10. Rayssiguier Y., Bussiere F., Gueux E., Rock E., Mazur A. Acute phase response in magnesium deficiency: possible relevance to atherosclerosis. Rayssiguier Y., Mazur A., Durlach J. Advances in Magnesium Research. Nutrition and Health. 2001;277-289 J. Libbey, London
11. Ravn H.B., Korsholm T.L., Falk E. Oral magnesium supplementation induces favorable antiatherogenic changes in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 21(5):2001;858-862
12. Shechter M., Sharir M., Labrador M.J., Forrester J., Silver B., Bairey Merz C.N. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation. 102:2000;2353-2358
13. Rasmussen H.S., Aurup P., Goldstein K., McNair P., Mortensen P.B., Larsen O.G., Lawaetz H. Influence of magnesium substitution therapy on blood lipid composition in patients with ischemic heart disease. A double-blind, placebo controlled study. Arch. Intern. Med. 149:1989;1050-1053
14. Wolf F.I., Cittadini A. Magnesium in cell proliferation and differentiation. Front. Biosci. 4:1999;D607-D617
15. Grzesiak J.J., Pierschbacher M.D. Shifts in the concentrations of magnesium and calcium in early porcine and rat wound fluids activate the cell migratory response. J. Clin. Invest. 95:1995;227-233
16. Maier J.A.M., Voulalas P., Roeder D., Maciag T. Extension of the life-span of human endothelial cells by an interleukin-1α antisense oligomer. Science. 249:1990;1570-1574
17. Garfinkel S., Hu X., Prudovsky I.A., McMahon G.A., Kapnik E.M., McDowell S.D., Maciag T. FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1 substrates. J. Cell Biol. 134:1996;783-791
18. Maier J.A.M., Barenghi L., Pagani F., Bradamante S., Comi P., Ragnotti G. The protective role of high-density lipoprotein on oxidized-low-density- lipoprotein-induced U937/endothelial cell interactions. Eur. J. Biochem. 221:1994;35-41
19. Verive M.J., Irazuzta J., Steinhart C.M., Orlowski J.P., Jaimovich D.G. Evaluating the frequency rate of hypomagnesemia in critically ill pediatric patients by using multiple regression analysis and a computer-based neural network. Crit. Care Med. 28(10):2000;3534-3539
20. Seelig M.S. Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review). J. Am. Coll. Nutr. 13(5):1994;429-446
21. Malpuech-Brugere C., Nowacki W., Daveau M., Gueux E., Linard C., Rock E., Lebreton J., Mazur A., Rayssiguier Y. Inflammatory response following acute magnesium deficiency in the rat. Biochim. Biophys. Acta. 1501:2000;91-98
22. Malpuech-Brugere C., Nowacki W., Rock E., Gueux E., Mazur A., Rayssiguier Y. Enhanced tumor necrosis factor - a production following endotoxin challenge in rats is an early event during magnesium deficiency. Biochim. Biophys. Acta. 1453:1999;35-40
23. Schneiderman J., Sawdey M.S., Keeton M.R., Bordin G.M., Bernstein E.F., Dilley R.B., Loskutoff D.J. Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc. Natl. Acad. Sci. U. S. A. 89:1992;6998-7002
24. Maier J.A.M., Statuto M., Ragnotti G. Endogenous interleukin 1α must be transported to the nucleus to exert its activity in human endothelial cells. Mol. Cell. Biol. 14:1994;1845-1851
25. Romani A., Scarpa A. Regulation of cell magnesium. Arch. Biochem. Biophys. 298:1992;1-12
26. Rubin H. Effect of Magnesium content on density-dependent regulation of the onset of DNA synthesis in transformed 3T3 cells. Cancer Res. 42:1982;1761-1766
27. Kosch M., Hausberg M., Westermann G., Koneke J., Matzkies F., Rahn K.H., Kisters K. Alterations in calcium and magnesium content of red cell membranes in patients with primary hypertension. Am. J. Hypertens. 14:2001;254-258
28. Zhang A., Cheng T.P., Altura B.T., Altura B.M. Mg2+ and caffeine-induced intracellular Ca2+ release in human vascular endothelial cells. Br. J. Pharmacol. 109:1993;291-292
29. Fullerton D.A., Hahn A.R., Agrafojo J., Sheridan B.C., McIntyre R.C. Magnesium is essential in mechanisms of pulmonary vasomotor control. J. Surg. Res. 63:1996;93-97
30. Yokoyama S., Nishida H.I., Smith T.L., Kummerow F.A. Combined effects of magnesium deficiency and an atherogenic level of low density lipoprotein on uptake and metabolism of low density lipoprotein by cultured human endothelial cells. I. Biochemical data. Magnes. Res. 7:1994;87-95
31. Suttorp N., Fuchs T., Seeger W., Wilke A., Drenckhahn D. Role of Ca2+ and Mg2+ for endothelial permeability of water and albumin in vitro. Lab. Invest. 61:1989;183-191
32. Banai S., Haggroth L., Epstein S.E., Casscells W. Influence of extracellular magnesium on capillary endothelial cell proliferation and migration. Circ. Res. 67:1990;645-650
33. Dickens B.F., Weglicki W.B., Li Y.S., Mak I.T. Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells. FEBS Lett. 311:1992;187-191
34. Nilsson I., Hoffmann I. Cell cycle regulation by the Cdc25 phosphatase family. Prog. Cell Cycle Res. 4:2000;107-114
35. Kosaka C., Sasaguri T., Ishida A., Ogata J. Cell cycle arrest in the G2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells. Am. J. Physiol. 270:1996;C170-C178
36. Littlefield N.A., Hass B.S., McGarry L.J., Morris S.M. Effect of magnesium on the growth and cell cycle of transformed and non-transformed epithelial rat liver cells in vitro. Cell Biol. Toxicol. 7:1991;203-214
37. Iseri L.T., French J.H. Magnesium: nature's physiologic calcium blocker. Am. Heart J. 108:1984;188-193
38. Yoshimura M., Oshima T., Matsuura H., Inoue T., Kambe M., Kajiyama G. Differential effects of extracellular Mg2+ on thrombin-induced and capacitative Ca2+ entry in human coronary arterial endothelial cells. Arterioscler. Thromb. Vasc. Biol. 17:1997;3356-3361
39. O'Donnell K., Harkes I.C., Dougherty L., Wicks I.P. Expression of receptor tyrosine kinase Axl and its ligand Gas6 in rheumatoid arthritis: evidence for a novel endothelial cell survival pathway. Am. J. Pathol. 154:1999;1171-1180
40. Melaragno M.G., Wuthrich D.A., Poppa V., Gill D., Lindner V., Berk B.C., Corson M.A. Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats. Circ. Res. 83:1998;697-704
41. Lapidos K.A., Woodhouse E.C., Kohn E.C., Masiero L. Mg(++)-induced endothelial cell migration: substratum selectivity and receptor-involvement. Angiogenesis. 4:2001;21-28