-
1
-
-
1842486792
-
The spindle checkpoint, aneuploidy, and cancer
-
Bharadwaj, R. & Yu, H. (2004) The spindle checkpoint, aneuploidy, and cancer. Oncogene 23, 2016-2027.
-
(2004)
Oncogene
, vol.23
, pp. 2016-2027
-
-
Bharadwaj, R.1
Yu, H.2
-
2
-
-
2642689658
-
Proteases to die for
-
Cryns, V. & Yuan, J. (1998) Proteases to die for. Genes Dev. 12, 1551-1570.
-
(1998)
Genes Dev.
, vol.12
, pp. 1551-1570
-
-
Cryns, V.1
Yuan, J.2
-
3
-
-
0032885388
-
Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
-
Earnshaw, W.C., Martins, L.M. & Kaufmann, S.H. (1999) Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68, 383-424.
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 383-424
-
-
Earnshaw, W.C.1
Martins, L.M.2
Kaufmann, S.H.3
-
4
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. & Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
5
-
-
34247270258
-
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase
-
Faragher, A.J., Sun, X.-M., Butterworth, M., Harper, N., Mulheran, M., Ruchaud, S., Earnshaw, W.C. & Cohen, G.M. (2007) Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. Mol. Biol. Cell 18, 1337-1347.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 1337-1347
-
-
Faragher, A.J.1
Sun, X.-M.2
Butterworth, M.3
Harper, N.4
Mulheran, M.5
Ruchaud, S.6
Earnshaw, W.C.7
Cohen, G.M.8
-
6
-
-
26444537963
-
Neural stem cell differentiation is dependent upon endogenous caspase 3 activity
-
Fernando, P., Brunette, S. & Megeney, L.A. (2005) Neural stem cell differentiation is dependent upon endogenous caspase 3 activity. FASEB J. 19, 1671-1673.
-
(2005)
FASEB J.
, vol.19
, pp. 1671-1673
-
-
Fernando, P.1
Brunette, S.2
Megeney, L.A.3
-
7
-
-
0242432345
-
Many cuts to ruin: A comprehensive update of caspase substrates
-
Fischer, U., Janicke, R.U. & Schulze-Osthoff, K. (2003) Many cuts to ruin: A comprehensive update of caspase substrates. Cell Death Differ. 10, 76-100.
-
(2003)
Cell Death Differ.
, vol.10
, pp. 76-100
-
-
Fischer, U.1
Janicke, R.U.2
Schulze-Osthoff, K.3
-
8
-
-
0036341291
-
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
-
Fulda, S., Wick, W., Weller, M. & Debatin, K.M. (2002) Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat. Med. 8, 808-815.
-
(2002)
Nat. Med.
, vol.8
, pp. 808-815
-
-
Fulda, S.1
Wick, W.2
Weller, M.3
Debatin, K.M.4
-
9
-
-
33745032590
-
Caspase 3, periodically expressed and activated at G2/M transition, is required for nocodazole-induced mitotic checkpoint
-
Hsu, S.L., Yu, C.T., Yin, S.C., Tang, M.J., Tien, A.C., Wu, Y.M. & Huang, C.Y. (2006) Caspase 3, periodically expressed and activated at G2/ M transition, is required for nocodazole-induced mitotic checkpoint. Apoptosis 11, 765-771.
-
(2006)
Apoptosis
, vol.11
, pp. 765-771
-
-
Hsu, S.L.1
Yu, C.T.2
Yin, S.C.3
Tang, M.J.4
Tien, A.C.5
Wu, Y.M.6
Huang, C.Y.7
-
10
-
-
0034282432
-
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
-
Huang, H., Joazeiro, C.A., Bonfoco, E., Kamada, S., Leverson, J.D. & Hunter, T. (2000) The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. J. Biol. Chem. 275, 26661-26664.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26661-26664
-
-
Huang, H.1
Joazeiro, C.A.2
Bonfoco, E.3
Kamada, S.4
Leverson, J.D.5
Hunter, T.6
-
11
-
-
19344368275
-
Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization
-
Huh, J.R., Vernooy, S.Y., Yu, H., Yan, N., Shi, Y., Guo, M. & Hay, B.A. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2, E15.
-
(2004)
PLoS Biol.
, vol.2
-
-
Huh, J.R.1
Vernooy, S.Y.2
Yu, H.3
Yan, N.4
Shi, Y.5
Guo, M.6
Hay, B.A.7
-
12
-
-
0035524309
-
Chromosome segregation and cancer: Cutting through the mystery
-
Jallepalli, P.V. & Lengauer, C. (2001) Chromosome segregation and cancer: Cutting through the mystery. Nat. Rev. Cancer 1, 109-117.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 109-117
-
-
Jallepalli, P.V.1
Lengauer, C.2
-
13
-
-
12544256390
-
Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s)
-
Kamada, S., Kikkawa, U., Tsujimoto, Y. & Hunter, T. (2005a) Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J. Biol. Chem. 280, 857-860.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 857-860
-
-
Kamada, S.1
Kikkawa, U.2
Tsujimoto, Y.3
Hunter, T.4
-
14
-
-
27144432371
-
A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association
-
Kamada, S., Kikkawa, U., Tsujimoto, Y. & Hunter, T. (2005b) A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. Mol. Cell. Biol. 25, 9469-9477.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 9469-9477
-
-
Kamada, S.1
Kikkawa, U.2
Tsujimoto, Y.3
Hunter, T.4
-
15
-
-
0032568321
-
Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells
-
Kanda, T., Sullivan, K.F. & Wahl, G.M. (1998) Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr. Biol. 8, 377-385.
-
(1998)
Curr. Biol.
, vol.8
, pp. 377-385
-
-
Kanda, T.1
Sullivan, K.F.2
Wahl, G.M.3
-
16
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan, M.B. & Bartek, J. (2004) Cell-cycle checkpoints and cancer. Nature 432, 316-323.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
17
-
-
27144461676
-
Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression
-
Kim, M., Murphy, K., Liu, F., Parker, S.E., Dowling, M.L., Baff, W. & Kao, G.D. (2005) Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression. Mol. Cell. Biol. 25, 9232-9248.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 9232-9248
-
-
Kim, M.1
Murphy, K.2
Liu, F.3
Parker, S.E.4
Dowling, M.L.5
Baff, W.6
Kao, G.D.7
-
18
-
-
0029956641
-
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
-
Kuida, K., Zheng, T.S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P. & Flavell, R.A. (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368-372.
-
(1996)
Nature
, vol.384
, pp. 368-372
-
-
Kuida, K.1
Zheng, T.S.2
Na, S.3
Kuan, C.4
Yang, D.5
Karasuyama, H.6
Rakic, P.7
Flavell, R.A.8
-
19
-
-
33746570157
-
Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs
-
Kuranaga, E., Kanuka, H., Tonoki, A., Takemoto, K., Tomioka, T., Kobayashi, M., Hayashi, S. & Miura, M. (2006) Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126, 583-596.
-
(2006)
Cell
, vol.126
, pp. 583-596
-
-
Kuranaga, E.1
Kanuka, H.2
Tonoki, A.3
Takemoto, K.4
Tomioka, T.5
Kobayashi, M.6
Hayashi, S.7
Miura, M.8
-
20
-
-
32444434664
-
Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis
-
Lakhani, S.A., Masud, A., Kuida, K., Porter, G.A. Jr., Booth, C.J., Mehal, W.Z., Inayat, I. & Flavell, R.A. (2006) Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis. Science 311, 847-851.
-
(2006)
Science
, vol.311
, pp. 847-851
-
-
Lakhani, S.A.1
Masud, A.2
Kuida, K.3
Porter Jr., G.A.4
Booth, C.J.5
Mehal, W.Z.6
Inayat, I.7
Flavell, R.A.8
-
21
-
-
33845483887
-
Caspases in cell survival, proliferation and differentiation
-
Lamkanfi, M., Festjens, N., Declercq, W., Vanden Berghe, T. & Vandenabeele, P. (2007) Caspases in cell survival, proliferation and differentiation. Cell Death Differ. 14, 44-55.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 44-55
-
-
Lamkanfi, M.1
Festjens, N.2
Declercq, W.3
Vanden Berghe, T.4
Vandenabeele, P.5
-
22
-
-
33947426526
-
The CASBAH: A searchable database of caspase substrates
-
Lüthi, A.U. & Martin, S.J. (2007) The CASBAH: A searchable database of caspase substrates. Cell Death Differ. 14, 641-650.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 641-650
-
-
Lüthi, A.U.1
Martin, S.J.2
-
23
-
-
33644996388
-
z-VAD-fmk inhibits peptide: N-glycanase and may result in ER stress
-
Misaghi, S., Korbel, G.A., Kessler, B., Spooner, E. & Ploegh, H.L. (2006) z-VAD-fmk inhibits peptide: N-glycanase and may result in ER stress. Cell Death Differ. 13, 163-165.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 163-165
-
-
Misaghi, S.1
Korbel, G.A.2
Kessler, B.3
Spooner, E.4
Ploegh, H.L.5
-
24
-
-
0036789555
-
The spindle checkpoint: Structural insights into dynamic signalling
-
Musacchio, A. & Hardwick, K.G. (2002) The spindle checkpoint: structural insights into dynamic signalling. Nat. Rev. Mol. Cell Biol. 3, 731-741.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 731-741
-
-
Musacchio, A.1
Hardwick, K.G.2
-
25
-
-
0037380579
-
Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system
-
Newton, K. & Strasser, A. (2003) Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system. Genes Dev. 17, 819-825.
-
(2003)
Genes Dev.
, vol.17
, pp. 819-825
-
-
Newton, K.1
Strasser, A.2
-
26
-
-
9244263076
-
Aneuploidy and cancer
-
Rajagopalan, H. & Lengauer, C. (2004) Aneuploidy and cancer. Nature 432, 338-341.
-
(2004)
Nature
, vol.432
, pp. 338-341
-
-
Rajagopalan, H.1
Lengauer, C.2
-
27
-
-
8444220527
-
Molecular mechanisms of caspase regulation during apoptosis
-
Riedl, S.J. & Shi, Y. (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat. Rev. Mol. Cell. Biol. 5, 897-907.
-
(2004)
Nat. Rev. Mol. Cell. Biol.
, vol.5
, pp. 897-907
-
-
Riedl, S.J.1
Shi, Y.2
-
29
-
-
11244322265
-
cIAP1 Localizes to the nuclear compartment and modulates the cell cycle
-
Samuel, T., Okada, K., Hyer, M., Welsh, K., Zapata, J.M. & Reed, J.C. (2005) cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 65, 210-218.
-
(2005)
Cancer Res.
, vol.65
, pp. 210-218
-
-
Samuel, T.1
Okada, K.2
Hyer, M.3
Welsh, K.4
Zapata, J.M.5
Reed, J.C.6
-
30
-
-
0034667372
-
Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells
-
Sasaki, H., Sheng, Y., Kotsuji, F. & Tsang, B.K. (2000) Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res. 60, 5659-5666.
-
(2000)
Cancer Res.
, vol.60
, pp. 5659-5666
-
-
Sasaki, H.1
Sheng, Y.2
Kotsuji, F.3
Tsang, B.K.4
-
31
-
-
9144234685
-
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
-
Schimmer, A.D., Welsh, K., Pinilla, C., et al. (2004) Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell 5, 25-35.
-
(2004)
Cancer Cell
, vol.5
, pp. 25-35
-
-
Schimmer, A.D.1
Welsh, K.2
Pinilla, C.3
-
32
-
-
0032898735
-
Non-specific effects of methyl ketone peptide inhibitors of caspases
-
Schotte, P., Declercq, W., Van Huffel, S., Vandenabeele, P. & Beyaert, R. (1999) Non-specific effects of methyl ketone peptide inhibitors of caspases. FEBS Lett. 442, 117-121.
-
(1999)
FEBS Lett.
, vol.442
, pp. 117-121
-
-
Schotte, P.1
Declercq, W.2
Van Huffel, S.3
Vandenabeele, P.4
Beyaert, R.5
-
33
-
-
33645299092
-
Caspases at the crossroads of immune-cell life and death
-
Siegel, R.M. (2006) Caspases at the crossroads of immune-cell life and death. Nat. Rev. Immunol. 6, 308-317.
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 308-317
-
-
Siegel, R.M.1
-
34
-
-
0035902601
-
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
-
Suzuki, Y., Nakabayashi, Y. & Takahashi, R. (2001) Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc. Natl. Acad. Sci. USA 98, 8662-8667.
-
(2001)
, vol.98
, pp. 8662-8667
-
-
Suzuki, Y.1
Nakabayashi, Y.2
Takahashi, R.3
-
35
-
-
0034064732
-
zVAD-fmk and DEVD-cho induced late mitosis arrest and apoptotic expressions
-
Swe, M. & Sit, K.H. (2000) zVAD-fmk and DEVD-cho induced late mitosis arrest and apoptotic expressions. Apoptosis 5, 29-36.
-
(2000)
Apoptosis
, vol.5
, pp. 29-36
-
-
Swe, M.1
Sit, K.H.2
-
36
-
-
0032575750
-
Caspases: Enemies within
-
Thornberry, N.A. & Lazebnik, Y. (1998) Caspases: Enemies within. Science 281, 1312-1316.
-
(1998)
Science
, vol.281
, pp. 1312-1316
-
-
Thornberry, N.A.1
Lazebnik, Y.2
-
37
-
-
0142092617
-
Caspase-3 regulates cell cycle in B cells: A consequence of substrate specificity
-
Woo, M., Hakem, R., Furlonger, C., Hakem, A., Duncan, G.S., Sasaki, T., Bouchard, D., Lu, L., Wu, G.E., Paige, C.J. & Mak, T.W. (2003) Caspase-3 regulates cell cycle in B cells: A consequence of substrate specificity. Nat. Immunol. 4, 1016-1022.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1016-1022
-
-
Woo, M.1
Hakem, R.2
Furlonger, C.3
Hakem, A.4
Duncan, G.S.5
Sasaki, T.6
Bouchard, D.7
Lu, L.8
Wu, G.E.9
Paige, C.J.10
Mak, T.W.11
-
38
-
-
0038521274
-
Caspase 3 activation is essential for efficient influenza virus propagation
-
Wurzer, W.J., Planz, O., Ehrhardt, C., Giner, M., Silberzahn, T., Pleschka, S. & Ludwig, S. (2003) Caspase 3 activation is essential for efficient influenza virus propagation. EMBO J. 22, 2717-2728.
-
(2003)
EMBO J.
, vol.22
, pp. 2717-2728
-
-
Wurzer, W.J.1
Planz, O.2
Ehrhardt, C.3
Giner, M.4
Silberzahn, T.5
Pleschka, S.6
Ludwig, S.7
-
39
-
-
0035938437
-
Expression of active caspase-3 in mitotic and postmitotic cells of the rat forebrain
-
Yan, X.X., Najbauer, J., Woo, C.C., Dashtipour, K., Ribak, C.E. & Leon, M. (2001) Expression of active caspase-3 in mitotic and postmitotic cells of the rat forebrain. J. Comp. Neurol. 433, 4-22.
-
(2001)
J. Comp. Neurol.
, vol.433
, pp. 4-22
-
-
Yan, X.X.1
Najbauer, J.2
Woo, C.C.3
Dashtipour, K.4
Ribak, C.E.5
Leon, M.6
-
40
-
-
0142188706
-
Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: Implication for cancer specific therapy
-
Yang, L., Cao, Z., Yan, H. & Wood, W.C. (2003) Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: Implication for cancer specific therapy. Cancer Res. 63, 6815-6824.
-
(2003)
Cancer Res.
, vol.63
, pp. 6815-6824
-
-
Yang, L.1
Cao, Z.2
Yan, H.3
Wood, W.C.4
-
41
-
-
0033709907
-
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
-
Zheng, T.S., Hunot, S., Kuida, K., Momoi, T., Srinivasan, A., Nicholson, D.W., Lazebnik, Y. & Flavell, R.A. (2000) Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. Nat. Med 6, 1241-1247.
-
(2000)
Nat. Med
, vol.6
, pp. 1241-1247
-
-
Zheng, T.S.1
Hunot, S.2
Kuida, K.3
Momoi, T.4
Srinivasan, A.5
Nicholson, D.W.6
Lazebnik, Y.7
Flavell, R.A.8
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