Telomerase expression: Only half the story

Cancer Biology and Therapy

Volumn 2, Issue 6, 2003, Pages 685-686

  Masutomi, Kenkichi ^a,b   Hahn, William C ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

DNA damage; Haploinsufficiency; hTERT; Telomere

Indexed keywords

DNA BINDING PROTEIN; PROTEIN P53; TELOMERASE;

CELL DIVISION; CELL STRAIN HCT116; CHROMOSOME 7; COMPARATIVE STUDY; DNA DAMAGE; ENZYMOLOGY; GENE DOSAGE; GENETIC RECOMBINATION; GENETICS; HOMEOSTASIS; HUMAN; METABOLISM; NEOPLASM; NOTE; PHOSPHORYLATION; PHYSIOLOGY; RADIATION DOSE; TELOMERE; TUMOR CELL LINE;

CELL DIVISION; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 7; DNA DAMAGE; DNA-BINDING PROTEINS; GENE DOSAGE; HCT116 CELLS; HOMEOSTASIS; HUMANS; NEOPLASMS; PHOSPHORYLATION; RADIATION TOLERANCE; RECOMBINATION, GENETIC; TELOMERASE; TELOMERE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 4444366488     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.2.6.557     Document Type: Note

References (37)

1. Harley CB, Kim NW, Prowse KR, et al. Telomerase, cell immortality, and cancer. Cold Spring Harb. Symp. Quant. Biol. 1994; 59:307-15.
2. Harley CB, Futcher AB Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345:458-60.
3. Counter CM, Avilion AA, Le Feuvre CE, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 1992; 11:1921-29.
4. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266:2011-15.
5. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279:349-52. (Pubitemid 28063364)
6. Vaziri H Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 1998; 8:279-82.
7. Hahn WC, Counter CM, Lundberg AS, et al. Creation of human tumor cells with defined genetic elements. Nature 1999; 400:464-68. (Pubitemid 29361801)
8. Hahn WC, Stewart SA, Brooks MW, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999; 5:1164-70. (Pubitemid 29474421)
9. Zhang X, Mar V, Zhou W, et al. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Gene Dev 1999; 13:2388-99. (Pubitemid 29453610)
10. Herbert B, Pitts AE, Baker SI, et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA 1999; 96:14276-81.
11. Damm K, Hemmann U, Garin-Chesa P, et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. Embo J 2001; 20:6958-68. (Pubitemid 34062288)
12. Gonzalez-Suarez E, Samper E, Flores JM, et al. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet 2000; 26:114-7.
13. Greenberg RA, Chin L, Femino A, et al. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell 1999; 97:515-25. (Pubitemid 29231174)
14. Shay JW, Wright WE Werbin H. Defining the molecular mechanisms of human cell immortalization. Biochim. Biophys. Acta 1991; 1072:1-7.
15. Artandi SE DePinho RA. A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev 2000; 10:39-46.
16. Broccoli D, Young JW de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 1995; 92:9082-86.
17. Allsopp RC, Cheshier S Weissman IL. Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J Exp Med 2001; 193:917-24. (Pubitemid 32525864)
18. Son NH, Murray S, Yanovski J, et al. Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J Immunol 2000; 165:1191-6. (Pubitemid 30604544)
19. Masutomi K, Yu EY, Khurts S, et al. Telomerase maintains telomere structure in normal human cells. Cell 2003; 114:241-53. (Pubitemid 36936917)
20. Wong JM, Kusdra L Collins K. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat Cell Biol 2002; 4:731-6. (Pubitemid 34993712)
21. Blasco MA, Rizen M, Greider CW, et al. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat. Genet. 1996; 12:200-04.
22. Stewart SA, Hahn WC, O'Connor BF, et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A 2002; 99:12606-11.
23. Gonzalez-Suarez E, Samper E, Ramirez A, et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. Embo J 2001; 20:2619-30. (Pubitemid 32938547)
24. Artandi SE, Alson S, Tietze MK, et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci USA 2002; 99:8191-6. (Pubitemid 34651028)
25. Hauguel T Bunz F. Haploinsufficiency of hTERT leads to telomere dysfunction and radiosensitivity in human cancer cells. In press.
26. Goytisolo FA, Samper E, Martin-Caballero J, et al. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med 2000; 192:1625-36.
27. Wong KK, Chang S, Weiler SR, et al. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet 2000; 26:85-8.
28. Aisner DL, Wright WE Shay JW. Telomerase regulation: not just flipping the switch. Curr Opin Genet Dev 2002; 12:80-5. (Pubitemid 34094994)
29. Liu Y, Kha H, Ungrin M, et al. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc Natl Acad Sci U S A 2002; 99:3597-602. (Pubitemid 34252152)
30. Hathcock KS, Hemann MT, Opperman KK, et al. Haploinsufficiency of mTR results in defects in telomere elongation. Proc Natl Acad Sci USA 2002; 99:3591-6. (Pubitemid 34252151)
31. Wright WE Shay JW. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med 2000; 6:849-51.
32. Hemann MT, Strong MA, Hao LY, et al. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001; 107:67-77. (Pubitemid 32972038)
33. Stewart SA, Ben-Porath I, Carey VC, et al. Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet 2003; 33:492-96. (Pubitemid 36390011)
34. Li GZ, Eller MS, Firoozabadi R, et al. Evidence that exposure of the telomere 3' overhang sequence induces senescence. Proc Natl Acad Sci USA 2003; 100:527-31. (Pubitemid 36126085)
35. Griffith JD, Comeau L, Rosenfield S, et al. Mammalian telomeres end in a large duplex loop. Cell 1999; 97:503-14. (Pubitemid 29231173)
36. de Lange T. Protection of mammalian telomeres. Oncogene 2002; 21:532-40.
37. de Lange T Jacks T. For better or worse? Telomerase inhibition and cancer. Cell 1999; 98:273-5.