Modulation of transcriptional sensitivity of mineralocorticoid and estrogen receptors

Journal of Steroid Biochemistry and Molecular Biology

Volumn 91, Issue 4-5, 2004, Pages 197-210

  Wang, Qi ^a   Anzick, Sarah ^a   Richter, William F ^a   Meltzer, Paul ^a   Simons Jr , S Stoney ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Co activators; Co repressors; Dose response curve; Estrogen receptors; Mineralocorticoid receptors; Partial agonist activity

Indexed keywords

DEXAMETHASONE 21 MESILATE; ESTROGEN RECEPTOR; MINERALOCORTICOID RECEPTOR;

ARTICLE; DRUG ACTIVITY; RECEPTOR SENSITIVITY; REGULATORY MECHANISM; TRANSACTIVATION;

AFFINITY LABELS; ANIMALS; CHO CELLS; CRICETINAE; DEXAMETHASONE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; HAPLORHINI; HISTONE ACETYLTRANSFERASES; HORMONE ANTAGONISTS; HUMANS; KIDNEY; LUCIFERASES; MINERALOCORTICOIDS; NUCLEAR PROTEINS; NUCLEAR RECEPTOR COACTIVATOR 2; RECEPTORS, ESTROGEN; REPRESSOR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 4444340629     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2004.04.007     Document Type: Article

References (66)

1. M.-J. Tsai, and B.W. O'Malley Molecular mechanisms of action of steroid/thyroid receptor superfamily members Annu. Rev. Biochem. 63 1994 451 486
2. C.K. Glass, and M.G. Rosenfeld The coregulator exchange in transcription functions of nuclear receptors Genes Dev. 14 2000 121 141
3. D. Robyr, A.P. Wolffe, and W. Wahli Nuclear hormone receptor coregulators in action: diversity for shared tasks Mol. Endocrinol. 14 2000 329 347
4. A.C. Steinmetz, J.P. Renaud, and D. Moras Binding of ligands and activation of transcription by nuclear receptors Annu. Rev. Biophys. Biomol. Struct. 30 2001 329 359
5. N.J. McKenna, and B.W. O'Malley Combinatorial control of gene expression by nuclear receptors and coregulators Cell 108 2002 465 474
6. S.S. Simons Jr., H. Oshima, and D. Szapary Higher levels of control: Modulation of steroid hormone-regulated gene transcription Mol. Endocrinol. 6 1992 995 1002
7. S.S. Simons Jr. The importance of being varied in steroid receptor transactivation TIPS 24 2003 253 259
8. S.A. Onate, S.Y. Tsai, M.-J. Tsai, and B.W. O'Malley Sequence and characterization of a coactivator for the steroid hormone receptor superfamily Science 270 1995 1354 1357
9. J.J. Voegel, M.J.S. Heine, C. Zechel, P. Chambon, and H. Gronemeyer T1F2, a 160 kDa transcriptional mediatior for the ligand-dependent activation function AF-2 of nuclear receptors EMBO J. 15 1996 3667 3675
10. H. Hong, K. Kohli, A. Trivedi, D.L. Johnson, and M.R. Stallcup GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors Proc. Natl. Acad. Sci. U.S.A. 93 1996 4948 4952
11. S.L. Anzick, J. Kononen, R.L. Walker, D.O. Azorsa, M.M. Tanner, X.Y. Guan, G. Sauter, O.P. Kallioniemi, J.M. Trent, and P.S. Meltzer AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer Science 277 1997 965 968
12. J.D. Chen, and R.M. Evans A transcriptional co-repressor that interacts with nuclear hormone receptors Nature 377 1995 454 457
13. A.J. Horlein, A.M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Soderstrom, C.K. Glass, and M.G. Rosenfeld Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor Nature 377 1995 397 404
14. U. Karvonen, O.A. Janne, and J.J. Palvimo Pure antiandrogens disrupt the recruitment of coactivator GRIP1 to colocalize with androgen receptor in nuclei FEBS Lett. 523 2002 43 47
15. D. Szapary, Y. Huang, and S.S. Simons Jr. Opposing effects of corepressor and coactivators in determining the dose-response curve of agonists, and residual agonist activity of antagonists, for glucocorticoid receptor regulated gene expression Mol. Endocrinol. 13 1999 2108 2121
16. S. Chen, N.J. Sarlis, and S.S. Simons Jr. Evidence for a common step in three different processes for modulating the kinetic properties of glucocorticoid receptor-induced gene transcription J. Biol. Chem. 275 2000 30106 30117
17. L.-N. Song, B. Huse, S. Rusconi, and S.S. Simons Jr. Transactivation specificity of glucocorticoid versus progesterone receptors: role of functionally different interactions of transcription factors with amino- and carboxyl-terminal receptor domains J. Biol. Chem. 276 2001 24806 24816
18. A. Vottero, T. Kino, H. Combe, P. Lecomte, and G.P. Chrousos A novel C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators J. Clin. Endocrinol. Metab. 87 2002 2658 2667
19. Y. He, D. Szapary, and S.S. Simons Jr. Modulation of induction properties of glucocorticoid receptor-agonist and -antagonist complexes by coactivators involves binding to receptors but is independent of ability of coactivators to augment transactivation J. Biol. Chem. 277 2002 49256 49266
20. Q. Wang, J.A. Blackford Jr, L.-N. Song, Y. Huang, S.S Simons Jr., Equilibrium interactions of corepressors and coactivators modulate the properties of agonist and antagonist complexes of glucocorticoid receptors, Mol. Endocrinol. 18 (2004) 1376-1395.
21. B.G. Rowan, N.L. Weigel, and B.W. O'Malley Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway J. Biol. Chem. 275 2000 4475 4483
22. G. Giannoukos, D. Szapary, C.L. Smith, J.E.W. Meeker, and S.S. Simons Jr. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties Mol. Endocrinol. 15 2001 255 270
23. Z. Liu, D. Auboeuf, J. Wong, J.D. Chen, S.Y. Tsai, M.J. Tsai, and B.W. O'Malley Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486 Proc. Natl. Acad. Sci. U.S.A. 99 2002 7940 7944
24. B.M. Forman, and H.H. Samuels Interactions among a subfamily of nuclear hormone receptors: The regulatory zipper model Mol. Endocrinol. 4 1990 1293 1301
25. J.W. Funder Adrenal steroids: new answers, new questions. mineralocorticoid receptors Science 237 1987 236 237
26. J.L. Arriza, C. Weinberger, G. Cerelli, T.M. Glaser, B.L. Handelin, D.E. Housman, and R.M. Evans Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor Science 237 1987 268 275
27. J.W. Funder, and K. Sheppard Adrenocortical steroids and the brain Annu. Rev. Physiol. 49 1987 397 411
28. B.S. McEwen, K.E.R. De, and W. Rostene Adrenal steroid receptors and actions in the nervous system Physiol. Rev. 66 1986 1121 1188
29. J.L. Arriza, R.B. Simerly, L.W. Swanson, and R.M. Evans The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response Neuron 1 1988 887 900
30. S. Yeh, and C. Chang Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells Proc. Natl. Acad. Sci. U.S.A. 93 1996 5517 5521
31. B.D. Darimont, R.L. Wagner, J.W. Apriletti, M.R. Stallcup, P.J. Kushner, J.D. Baxter, R.J. Fletterick, and K.R. Yamamoto Structure and specificity of nuclear receptor-coactivator interactions Genes Dev. 12 1998 3343 3356
32. L.A. Paige, D.J. Christensen, H. Gron, J.D. Norris, E.B. Gottlin, K.M. Padilla, C.Y. Chang, L.M. Ballas, P.T. Hamilton, D.P. McDonnell, and D.M. Fowlkes Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta Proc. Natl. Acad. Sci. U.S.A. 96 1999 3999 4004
33. O.C. Meijer Coregulator proteins and corticosteroid action in the brain J. Neuroendocrinol. 14 2002 499 505
34. D. Szapary, M. Xu, and S.S. Simons Jr. Induction properties of a transiently transfected glucocorticoid-responsive gene vary with glucocorticoid receptor concentration J. Biol. Chem. 271 1996 30576 30582
35. M. Pons, and S.S. Simons Jr. Facile, high yield synthesis of spiro C-17-steroidal oxetan-3'-ones J. Org. Chem. 46 1981 3262 3264
36. S.S. Simons Jr., M. Pons, and D.F. Johnson α-Keto mesylate: a reactive thiol-specific functional group J. Org. Chem. 45 1980 3084 3088
37. N.J. Sarlis, S.F. Bayly, D. Szapary, and S.S. Simons Jr. Quantity of partial agonist activity for antiglucocorticoids complexed with mutant glucocorticoid receptors is constant in two different transactivation assays but not predictable from steroid structure J. Steroid Biochem. Mol. Biol. 68 1999 89 102
38. P. Ordentlich, M. Downes, W. Xie, A. Genin, N.B. Spinner, and R.M. Evans Unique forms of human and mouse nuclear receptor co-repressor SMRT Proc. Natl. Acad. Sci. U.S.A. 96 1999 2639 2644
39. S.K. Nordeen, B.J. Bona, C.A. Beck, D.P. Edwards, K.C. Borror, and D.B. DeFranco The two faces of a steroid antagonist: when an antagonist isn't Steroids 60 1995 97 104
40. J.J. Voegel, M.J.S. Heine, M. Tini, V. Vivat, P. Chambon, and H. Gronemeyer The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways EMBO J. 17 1998 507 519
41. H. Hong, K. Kohl, M.J. Garabedian, and M.R. Stallcup GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors Mol. Cell Biol. 17 1997 2735 2744
42. K.-A. Sheppard, K.M. Phelps, A.J. Williams, D. Thanos, C.K. Glass, M.G. Rosenfeld, M.E. Gerritsen, and T. Collins Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1 J. Biol. Chem. 273 1998 29291 29294
43. Y. Morishima, K.C. Kanelakis, A.M. Silverstein, K.D. Dittmar, L. Estrada, and W.B. Pratt The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system J. Biol. Chem. 275 2000 6894 6900
44. J.D. Graham, and C.L. Clarke Physiological action of progesterone in target tissues Endocr. Rev. 18 1997 502 519
45. R.B. Dickson, and M.E. Lippman Molecular biology of breast cancer CANCER: Principals and Practice of Oncology 6th Ed. 2001 1633 1651
46. S.L. Anzick, D.O. Azorsa, S.S. Simons Jr., and P.S. Meltzer Phenotypic alterations in breast cancer cells overexpressing the nuclear receptor co-activator AIB1 BMC Cancer 3 2003 22
47. H. Oshima, and S.S. Simons Jr. Modulation of transcription factor activity by a distant steroid modulatory element Mol. Endocrinol. 6 1992 416 428
48. H. Zeng, S.Y. Plisov, and S.S. Simons Jr. Ability of the glucocorticoid modulatory element (GME) to modify glucocorticoid receptor transactivation indicates parallel pathways for the expression of GME and glucocorticoid response element activities Mol. Cell Endocrinol. 162 2000 221 234
49. S. Kaul, J.A. Blackford Jr., J. Chen, V.V. Ogryzko, and S.S. Simons Jr. Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins Mol. Endocrinol. 2000 14
50. M.M. Montano, W.L. Kraus, and B.S. Katzenellenbogen Identification of a novel transferable cis-element in the promoter of an estrogen-responsive gene that modulates sensitivity to hormone and antihormone Mol. Endocrinol. 11 1997 330 341
51. M.I. Gonzalez, and D.M. Robins Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1 J. Biol. Chem. 276 2001 6420 6428
52. J.M. Hall, D.P. McDonnell, and K.S. Korach Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements Mol. Endocrinol. 16 2002 469 486
53. S. Cho, J.A. Blackford Jr., S.S. Simons Jr., Role of activation function domain 1, DNA binding, and coactivator in the expression of partial agonist activity of glucocorticoid receptor complexes. (submitted).
54. M. Herdick, Y. Bury, M. Quack, M.R. Uskokovic, P. Polly, and C. Carlberg Response element and coactivator-mediated conformational change of the vitamin D(3) receptor permits sensitive interaction with agonists Mol. Pharmacol. 57 2000 1206 1217
55. M.J. Garabedian, and K.R. Yamamoto Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast Mol. Biol. Cell 3 1992 1245 1257
56. A.P.H. Wright, and J.A. Gustafsson Glucocorticoid-specific gene activation by the intact human glucocorticoid receptor expressed in yeast. Glucocorticoid specificity depends on low level receptor expression J. Biol. Chem. 267 1992 11191 11195
57. A. Kralli, S.P. Bohen, and K.R. Yamamoto LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones Proc. Natl. Acad. Sci. U.S.A. 92 1995 4701 4705
58. T. Ojasoo, J.-C. Dore, J. Gilbert, and J.-P. Raynaud Binding of steroid to the progestin and glucocorticoid receptors analyzed by correspondence analysis J. Med. Chem. 31 1988 1160 1169
59. H. Oshima, and S.S. Simons Jr. Sequence-selective interactions of transcription factor elements with tandem glucocorticoid-responsive elements at physiological steroid concentrations J. Biol. Chem. 268 1993 26858 26865
60. S. Kaul, J.A. Blackford Jr., S. Cho, and S.S. Simons Jr. Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors J. Biol. Chem. 277 2002 12541 12549
61. T. Trapp, R. Rupprecht, M. Castren, J.M.H.M. Reul, and F. Holsboer Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS Neuron 13 1994 1457 1462
62. W. Liu, J. Wang, N.K. Sauter, and D. Pearce Steroid receptor heterodimerization demonstrated in vitro and in vivo Proc. Natl. Acad. Sci. U.S.A. 92 1995 12480 12484
63. X.M. Ou, J.M. Storring, N. Kushwaha, and P.R. Albert Heterodimerization of mineralocorticoid and glucocorticoid receptors at a novel negative response element of the 5-HT1A receptor gene J. Biol. Chem. 276 2001 14299 14307
64. S.L. Planey, A. Derfoul, A. Steplewski, N.M. Robertson, and G. Litwack Inhibition of glucocorticoid-induced apoptosis in 697 pre-B lymphocytes by the mineralocorticoid receptor N-terminal domain J. Biol. Chem. 277 2002 42188 42196
65. E. Metzger, J.M. Muller, S. Ferrari, R. Buettner, and R. Schule A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer EMBO J. 22 2003 270 280
66. B. Hanstein, H. Liu, M.C. Yancisin, and M. Brown Functional analysis of a novel estrogen receptor-beta isoform Mol. Endocrinol. 13 1999 129 137