Exploration of the importance of the P2-P3 -NHCO-Moiety in a potent di- or tripeptide inhibitor of calpain I: Insights into the development of nonpeptidic inhibitors of calpain I

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 5, 1998, Pages 509-522

  Chatterjee, Sankar ^a   Iqbal, Mohamed ^a   Mallya, Satish ^a   Senadhi, Shobha E ^a   O'Kane, Teresa M ^a   McKenna, Beth Ann ^a   Bozyczko Coyne, Donna ^a   Kauer, James C ^a   Siman, Robert ^a   Mallamo, John P ^a  

^a CEPHALON INC   (United States)

Author keywords

Calpain I; Carbamethylene; Ketomethylene; Peptidomimetic; Stroke

Indexed keywords

CALPAIN; CALPASTATIN; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDE; OLIGOPEPTIDE; RECOMBINANT PROTEIN;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; PROTEIN CONFORMATION; SYNTHESIS;

CALPAIN; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; OLIGOPEPTIDES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED;

EID: 0031596464     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00009-1     Document Type: Article

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