Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats

Neurochemistry International

Volumn 45, Issue 7, 2004, Pages 1087-1094

  Rosa, Rafael B ^a   Schwarzbold, Carolina ^a   Dalcin, Karina B ^a   Ghisleni, Gabrielle C ^a   Ribeiro, César A J ^a   Moretto, Maria B ^d   Frizzo, Marcos E S ^a   Hoffmann, Georg F ^b   Souza, Diogo O ^a   Wajner, Moacir ^a,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^d Hosp de Clinicas de Porto Alegre ^*

Author keywords

3 Hydroxyglutaric acid; Excitotoxicity; Glutamate; Glutaric acidemia type I; Glutaryl CoA dehydrogenase; NMDA receptors

Indexed keywords

3 HYDROXYGLUTARIC ACID; CALCIUM; DIZOCILPINE; EXCITATORY AMINO ACID; GLUTARIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEPTH STIMULATION; CHOLINERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; IN VITRO STUDY; MALE; MEMBRANE BINDING; MOLECULAR INTERACTION; NEUROPHYSIOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RAT; RECEPTOR BINDING; STATISTICAL SIGNIFICANCE; SYNAPTIC MEMBRANE;

ANIMALS; ANIMALS, NEWBORN; CELL MEMBRANE; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTARATES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 4444334755     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2004.05.001     Document Type: Article

References (36)

1. Bolshakov K.V., Gmiro V.E., Tikhonov D.B., Magazanik L.G. Determinants of trapping block of N-methyl-D-aspartate receptor channels. J. Neurochem. 87:2003;56-65
2. Brismar J., Ozand P.T. CT, MR of the brain in glutaric acidemia type I: a review of 59 published cases and a report of 5 new patients. Am. J. Neuroradiol. 16:1995;675-683
3. Chapman A.G. Glutamate receptors in epilepsy. Prog. Brain Res. 116:1988;371-383
4. Chow C.W., Haan E.A., Goodman S.I., Anderson R.M., Evans W.A., Kleinschmidt-DeMasters B.K., Wise G., McGill J.J., Danks D.M. Neuropathology in glutaric acidaemia type 1. Acta Neuropathol. (Berl.). 76:1988;590-594
5. Danbolt N.C. Glutamate uptake (1994). The high affinity uptake system for excitatory amino acids in the brain. Prog. Neurobiol. 44:1994;377-396
6. Eason K.E., Aronstam R.S. Influence of sulfhydryl reagents on potassium-stimulated calcium uptake by rat brain synaptosomes. Res. Commun. Chem. Pathol. Pharmacol. 44:1984;503-506
7. 3H ]glutamate binding to fresh and frozen crude plasma membranes isolated from cerebral cortex of adult rats Biochem. Mol. Biol. Int. 44:1998;1265-1272
8. 2+ Eur. J. Pharmacol. 245:1993;233-239
9. Flott-Rahmel B., Falter C., Schluff P., Fingerhut R., Christensen E., Jakobs C., Musshoff U., Fautek J.D., Ludolph A., Ullrich K. Nerve cell lesions caused by 3-hydroxyglutaric acid: a possible mechanism for neurodegeneration in glutaric acidaemia. I. J. Inherit. Metab. Dis. 20:1997;387-390
10. Forstner R., Hoffmann G.F., Gassner I., Heideman P., De Klerk J.B., Lawrenz-Wolf B., Doringer E., Weiss-Wichert P., Troger J., Colombo J.P., Plochl E. Glutaric aciduria type I: ultrasonographic demonstration of early signs. Pediatr. Radiol. 29:1999;138-143
11. Frizzo M.E.S., Schwarzbold C., Porciúncula L.O., Dalcin K.B., Rosa R.B., Ribeiro C.A.J., Souza D.O., Wajner M. 3-Hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats. Neurochem. Int. 44:2004;345-353
12. Goodman, S.I., Frerman, F.E., 2001. Organic acidemias due to defects in lysine oxidation: 2-ketoadipic academia and glutaric acidemia. In: Scriver, C.R., Beaudet, A.L., Sly, W.S., Walle, D., (Eds.), The Metabolic and Molecular Bases of Inherited Disease, eighth ed. McGraw-Hill, New York, pp. 2195-2204.
13. Goodman S.I., Norenberg M.D., Shikes R.H., Breslich D.J., Moe P.G. Glutaric aciduria type 1: biochemical and morphological considerations. J. Pediatr. 90:1977;746-750
14. Hoffmann G.F., Zschocke J. Glutaric aciduria type I: From clinical, biochemical and molecular diversity to successful therapy. J. Inherit. Metab. Dis. 22:1999;381-391
15. Hoffmann G.F., Gibson K.M., Trekz F.K., Nyhan W.L., Bremer H.J., Rating D. Neurological manifestations of organic acid disorders. Eur. J. Pediatr. 153:1994;S94-S100
16. Jones D.H., Matus A.I. Isolation of synaptic plasma membrane from brain by combined flotation-sedmentation density gradient centrifugation. Biochim. Biophys. Acta. 356:1974;276-287
17. Kölker S., Ahlemeyer B., Krieglstein J., Hoffmann G.F. 3-Hydroxyglutaric and glutaric acids are neurotoxic through NMDA receptors in vitro. J. Inherit. Metab. Dis. 22:1999;259-262
18. Kölker S., Ahlemeyer B., Krieglstein J., Hoffmann G.F. Cerebral organic acid disorders induce neuronal damage via excitotoxic organic acids in vitro. Amino Acids. 18:2000a;31-40
19. Kölker S., Ahlemeyer B., Krieglstein J., Hoffmann G.F. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: A new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. Pediatr. Res. 47:2000b;495-503
20. Kölker S., Ahlemeyer B., Krieglstein J., Hoffmann G.F. Evaluation of trigger factors of acute encephalopathy in glutaric aciduria type I: fever and tumour necrosis factor-alpha. J. Inherit. Metab. Dis. 23:2000c;359-362
21. Kölker S., Ahlemeyer B., Krieglstein J., Hoffmann G.F. Contribution of reactive oxygen species to 3-hydroxyglutarate neurotoxicity in primary neuronal cultures from chick embryo telencephalons. Pediatr. Res. 50:2001a;76-82
22. Kölker S., Ahlemeyer B., Hühne R., Mayatepek E., Krieglstein J., Hoffmann G.F. Potentiation of 3-hydroxyglutarate neurotoxicity following induction of astrocytic iNOS in neonatal rat hippocampal cultures. Eur. J. Neurosci. 13:2001b;2115-2122
23. + dependence of 3-hydroxyglutarate-induced excitotoxicity in primary neuronal cultures from chick embryo telencephalons. Pediatr. Res. 52:2002a;199-206
24. Kölker S., Okun J.G., Ahlemeyer B., Wyse A.T., Horster F., Wajner M., Kohlmuller D., Mayatepek E., Krieglstein J., Hoffmann G.F. Chronic treatment with glutaric acid induces partial tolerance to excitotoxicity in neuronal cultures from chick embryo telencephalons. J. Neurosci. Res. 685:2002b;424-431
25. Kölker S., Hoffmann G.F., Schor D.S.M., Feyh P., Wagner L., Jeffrey I., Pourfarzam M., Okum J.G., Zschocke J., Baric I., Bain M.D., Jakobs C., Chalmers R.A. Gluratyl-CoA dehydrogenase deficiency: Region-specific analysis of organic acids and acylcarnitines in post mortem brain predicts vulterability of the putamen. Neuropediatrics. 34:2003;253-260
26. Latini A., Rosa R.B., Scussiato K., Llesuy S., Belló-Klein A., Wajner M. 3-Hydroxyglutaric acid induces oxidative stress and decreases the antioxidant defenses in cerebral cortex of young rats. Brain Res. 956:2002;367-373
27. Lowry O.H., Roseborough N.R., Farr A.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275
28. Meldrum B., Garthwaite J. Excitatory amino acid neurotoxicity and neurodegnerative disease. Trends Pharmacol. Sci. 11:1990;379-387
29. Meldrum B. Implications for neuroprotective treatments. Prog. Brain Res. 135:2002;487-495
30. Mello C.F., de Kölker S., Ahlemeyer B., de Souza F.R., Fighera M.R., Mayatepek E., Krieglstein J., Hoffmann G.F., Wajner M. Intrastriatal administration of 3-hydroxyglutaric acid induces convulsions and striatal lesions in rats. Brain Res. 916:2001;70-75
31. Olney, J.W., 1980. Excitotoxic mechanisms of neurotoxicity. In: Spencer P.S. Schaumburg H.H. (Eds), Clinical and Experimental Neurotoxicology, Williams & Wilkins, Baltimore, MD, pp. 272-294.
32. Ozawa S., Kamyiar K., Tsuzuki K. Glutamate receptors in the mammalian cerebral nervous system. Prog. Neurobiol. 54:1998;581-618
33. Planells-Cases R., Montoliu C., Humet M., Fernandez A.M., Garcia-Martinez C., Valera E., Merino J.M., Perez-Paya E., Messeguer A., Felipo V., Ferrer-Montiel A. A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J. Pharmacol. Exp. Ther. 302:2002;163-173
34. Rothman S.M., Olney J.W. Excitotoxicity and the NMDA receptors. Trends Neurosci. 10:1987;299-302
35. Strauss K.A., Morton H. Type I glutaric aciduria, Part 2: A model of acute striatal necrosis. Am. J. Med. Gen. 121:2003;53-70
36. Ullrich K., Flott-Rahmel B., Schluff P., Musshoff U., Das A., Lücke T., Steinfeld R., Christensen E., Jacobs C., Ludolph A., Neu A., Röper R. Glutaric aciduria type I: pathomechanisms of neurodegeneration. J. Inherit. Metab. Dis. 22:1999;392-403