Potentiation of 3-hydroxyglutarate neurotoxicity following induction of astrocytic iNOS in neonatal rat hippocampal cultures

European Journal of Neuroscience

Volumn 13, Issue 11, 2001, Pages 2115-2122

  Kölker, Stefan ^a   Ahlemeyer, Barbara ^b   Hühne, Ricarda ^b   Mayatepek, Ertan ^a   Krieglstein, Josef ^b   Hoffmann, Georg F ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Excitotoxicity; Glutaryl CoA dehydrogenase deficiency; Nitric oxide; Reactive oxygen species

Indexed keywords

3 HYDROXYGLUTARIC ACID; AMINOGUANIDINE; CATALASE; CYTOKINE; DIZOCILPINE; GAMMA INTERFERON; GLUTARIC ACID DERIVATIVE; GLUTARYL COENZYME A DEHYDROGENASE; INTERLEUKIN 1BETA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CELL; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME DEFICIENCY; ENZYME INDUCTION; GLUTARYL COENZYME A DEHYDROGENASE DEFICIENCY; HIPPOCAMPUS; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TOXICOKINETICS;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN DISEASES, METABOLIC, INBORN; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYTOKINES; DRUG INTERACTIONS; ENZYME INHIBITORS; GLUTARATES; GLUTARYL-COA DEHYDROGENASE; HIPPOCAMPUS; INTERFERON TYPE II; INTERLEUKIN-1; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0034960955     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01595.x     Document Type: Article

References (47)

1. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
2. Age at symptom onset predicts severity of motor impairment and clinical outcome of glutaric aciduria type I
3. CT and MR of the brain in glutaric aciduria type I: A review of 59 published cases and a report of 5 new patients
4. Glutaryl-CoA dehydrogenase deficiency in Spain: Evidence of two groups of patients, genetically and biochemically distinct
5. Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: Involvement of nitric oxide and of N-methyl-D-aspartate receptors
6. Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism
7. 3H-labelled glutaryl-CoA: Application in the genotyping of the glutaryl-CoA dehydrogenase locus
8. Nitric oxide: Diverse actions in the central and peripheral nervous system
9. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice
10. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
11. Glutaric aciduria: Inherited deficiency of glutaryl-CoA dehydrogenase activity
12. Glutaryl-CoA dehydrogenase mutations in glutaric acidemia (type I): Review and report of thirty novel mutations
13. 15N-nitrate in biological fluids
14. Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS
15. Potentiation of oxygen-glucose deprivation-induced neuronal death after induction of iNOS
16. Clinical course, early diagnosis, treatment, and prevention of disease in glutaryl-CoA dehydrogenase deficiency
17. Cytokine-mediated neuronal apoptosis
18. The reaction of NO with superoxide
19. Requirements for transcription factor IRF-1 in NO synthase induction in macrophages
20. Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO
21. Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia
22. Quantitative determination of glutamate-mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
23. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: A new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency
24. Evaluation of trigger factors of acute encephalopathy in glutaric aciduria type I: Fever and tumor necrosis factor-α
25. Ionic dependence of neuronal damage induced by 3-hydroxyglutaric acid in vitro
26. Contribution of reactive oxygen species to 3-hydroxyglutarate neurotoxicity in primary neuronal cultures from chick embryo telencephalons
27. Acute encephalopathy despite early therapy in a patient with homozygosity for E365K in the glutaryl-CoA dehydrogenase gene
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. NMDA-dependent superoxide production and neurotoxicity
30. A redox-based mechanism for the neuroprotective and neurodestructive effect of nitric oxide and related nitroso-compounds
31. Expression of type II nitric oxide synthase in primary human astrocytes and microglia. Role of IL-1β and IL-1 receptor antagonist
32. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
33. Protein measurement with the Folin phenol reagent
34. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
35. Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokinestimulated C6 glial cells
36. Requirement for superoxide in excitotoxic cell death
37. Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus
38. NMDA neurotoxicity in murine cortical cell cultures is not attenuated by hemoglobin or inhibition of nitric oxide synthesis
39. Interaction of interferon regulatory factor-1 and nuclear factor κB during activation of inducible nitric oxide synthase transcription
40. NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: Role of mitochondria
41. Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene
42. Glutaric aciduria type I: Pathomechanism of neurodegeneration
43. G-nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils
44. Role of transcription factor NF-kappaB/Rel in the induction of nitric oxide synthase
45. Inhibition of nitric oxide synthesis increases focal ischemia in rat
46. Cytokine modulation of glial glutamate uptake: A possible involvement of nitric oxide
47. Mutation analysis in glutaric aciduria type I