Determinants of trapping block of N-methyl-D-aspartate receptor channels

Journal of Neurochemistry

Volumn 87, Issue 1, 2003, Pages 56-65

  Bolshakov, K V ^a   Gmiro, V E ^b   Tikhonov, D B ^a   Magazanik, L G ^a  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Russian Federation)

Author keywords

Channel block; Ion channel; Kinetics; NMDA receptor; Trapping; Voltage dependence

Indexed keywords

AMANTADINE; AMINOACRIDINE; DIZOCILPINE; ION CHANNEL; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; TETRAPENTYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ELECTRIC POTENTIAL; HIPPOCAMPUS; KINETICS; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RECEPTOR BLOCKING;

AMANTADINE; ANIMALS; CYCLOHEXANES; CYCLOHEXYLAMINES; DIAMINES; DRUG DESIGN; ETHYLAMINES; EXCITATORY AMINO ACID ANTAGONISTS; MODELS, MOLECULAR; NEURONS; PATCH-CLAMP TECHNIQUES; PHENCYCLIDINE; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0141755106     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01956.x     Document Type: Article

References (31)

1. Antonov S. M. and Johnson J. W. (1996) Voltage-dependent interaction of open-channel blocking molecules with gating of NMDA receptors in rat cortical neurons. J. Physiol. 493, 425-445.
2. Benveniste M. and Mayer M. L. (1995) Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9-aminoacridine. J. Physiol. 483, 367-384.
3. Blanpied T. A., Boeckman F. A., Aizeman E. and Johnson J. W. (1997) Trapping channel block of NMDA-activated responses by amantadine and memantine. J. Neurophysiol. 77, 309-323.
4. Bolshakov K. V., Tikhonov D. B., Gmiro V. E. and Magazanik L. G. (2000) Different arrangement of hydrophobic and nucleophilic components of channel binding sites in NMDA and AMPA receptor is revealed by channel blockade. Neurosci. Lett. 291, 101-104.
5. Dingledine R., Borges K., Bowie D. and Traynelis S. F. (1999) The glutamate receptor ion channels. Pharmacol. Rev. 51, 7-61.
6. Huetter J. E. and Bean B. P. (1988) Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc. Natl Acad. Sci. USA 85, 1307-1311.
7. Jiang Y., Lee A., Chen J., Cadene M., Chait B. T. and MacKinnon R. (2002) The open pore conformation of potassium channels. Nature 417, 523-526.
8. Jones K. S., VanDongen H. M. and VanDongen A. M. (2002) The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. J. Neurosci. 22, 2044-2053.
9. Kashiwagi K., Masuko T., Nguyen C. D., Kuno T., Tanaka I., Igarashi K. and Williams K. (2002) Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore. Mol. Pharmacol. 61, 533-545.
10. Kroemer R. T., Koutsilieri E., Hecht P., Liedl K. R., Riederer P. and Kornhuber J. (1998) Quantitative analysis of the structural requirements for blockade of the N-methyl-D-aspartate receptor at the phencyclidine binding site. J Med. Chem. 41, 393-400.
11. + channels and ionotropic glutamate receptors? Trends Neurosci. 26, 27-32.
12. Li Z. and Scheraga H. A. (1987) Monte Carlo-minimization approach to the multiple-minima problem in protein folding. Proc. Natl Acad. Sci. USA 84, 6611-6615.
13. MacDonald J. F., Bartlett M. C., Mody I., Pahapill P., Reynolds J. N., Salter M. W., Schneiderman J. H. and Pennefather P. S. (1991) Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones. J. Physiol. 432, 483-508.
14. Mealing G. A. R., Lanthom T. H., Murray R. J., Small D. L. and Morley P. (1999) Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonist with similar kinetics of block. J Pharmacol. Exp. Ther. 288, 204-210.
15. Mealing G. A. R., Lanthorn T. H., Small D. L., Murray R. J., Mattes K. C., Comas T. M. and Morley P. (2001) Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block. J. Pharmacol. Exp. Ther. 297, 906-914.
16. Panchenko V. A., Glasser C. R. and Mayer M. L. (2001) Structural similarities between glutamate receptor channels and K channels examined by scanning mutagenesis. J Gen. Physiol. 117, 345-359.
17. Parsons C. G., Danysz W. and Quack G. (1998) Glutamate in CNS disorders as a target for drug development: an update. Drug News Perspectives. 11, 523-569.
18. Sobolevsky A. I. (1999) Two component blocking kinetics of open NMDA channels by organic cations. Biochem. Biophys. Acta 1416, 69-91.
19. Sobolevsky A. I. and Yelshansky M. V. (2000) The trapping block of NMDA receptor channels in acutely isolated rat hippocampal neurones. J. Physiol. 526, 493-506.
20. Sobolevsky A. I., Koshelev S. G. and Khodorov B. I. (1999) Probing of NMDA channels with fast blockers. J. Neurosci. 19, 10611-10626.
21. Tikhonov D. B., Mellor I. R., Usherwood P. N. R. and Magazanik L. G. (2002) Modeling of the pore domain of the GLUR1 channel: homology with K channel and binding of channel blockers. Biophys. J. 82, 1884-1893.
22. Tikhonov D. B., Zhorov B. S. and Magazanik L. G. (1999) Intersegment hydrogen bonds as possible structural determinants of the N/Q/R. site in glutamate receptors. Biophys. J 77, 1914-1926.
23. Villarroel A., Burnashev N. and Sakmann B. (1995) Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophys. J. 68, 866-875.
24. Vorobjev V. S. (1991) Vibrodissociation of sliced mammalian nervous tissue. J. Neurosci. Methods 38, 145-150.
25. Vorobjev V. S. and Sharonova I. N. (1994) Tetrahydroaminoacridine blocks and prolongs NMDA receptor mediated responses in a voltage-dependent manner. Eur. J. Pharmacol. 253, 1-8.
26. Weiner S. J., Kollman P. A., Case D. A., Singh U. C., Chio C., Alagona G., Profeta S. and Weiner P. K. (1984) A new force field for molecular mechanical simulation of nucleic acids and proteins. J. Am. Chem. Soc. 106, 765-784.
27. Wood M. W., VanDongen H. M. A. and VanDongen A. M. J. (1995) Structural conservation of ion conduction pathways in K channels and glutamate receptors. Proc. Natl Acad. Sci. USA 92, 4882-4886.
28. Woodhull A. M. (1973) Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61, 687-708.
29. Zhorov B. S. (1981) Vector method for calculating derivatives of energy of atom-atom interactions of complex molecules according to generalized coordinates. J. Struct. Chem. 22, 4-8.
30. + ions and dihydropyridine ligand. Biophys. J 70, 22-37.
31. Zhou M., Morais-Cabral J.H., Mann S. and MacKinnon R. (2001) Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411, 657-661.