Contribution of reactive oxygen species to 3-hydroxyglutarate neurotoxicity in primary neuronal cultures from chick embryo telencephalons

Pediatric Research

Volumn 50, Issue 1 I, 2001, Pages 76-82

  Kolker S ^a   Ahlemeyer, B ^a   Krieglstein, J ^a   Hoffmann, G F ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYGLUTARIC ACID; ALPHA TOCOPHEROL; CREATINE; DIZOCILPINE; GLUTARIC ACID DERIVATIVE; GLUTARYL COENZYME A DEHYDROGENASE; MELATONIN; N ACETYL S NITROSOPENICILLAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN METABOLISM; CELL VIABILITY; CHICK EMBRYO; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; NERVE CELL CULTURE; NERVE CELL EXCITABILITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TELENCEPHALON;

EID: 0034979803     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200107000-00015     Document Type: Article

References (49)

1. Clinical course, early diagnosis, treatment, and prevention of disease in glutaryl-CoA dehydrogenase deficiency
2. Glutaric aciduria: Biochemical and morphological considerations
3. Glutaric aciduria type I: An atypical presentation together with some observations upon treatment and the possible cause of cerebral damage
4. Inhibition of brain glutamate decarboxylase by glutarate, glutaconate, and beta-hydroxyglutarate: Explanation of the symptoms in glutaric aciduria?
5. Hypothesis: A role for quinolinic acid in the neuropathology of glutaric aciduria type 1
6. Glutaric aciduria type I: Pathomechanism of neurodegeneration
7. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: A new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency
8. The NMDA receptor subunit NR2B of neonatal rat brain: Complex formation and enrichment in axonal growth cones
9. Modulation of neuronal migration by NMDA receptors
10. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
11. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
12. Calcium, free radicals, and excitotoxic neuronal death in primary cell culture
13. Requirement for superoxide in excitotoxic cell death
14. NMDA-dependent superoxide production and neurotoxicity
15. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
16. Nitric oxide: Diverse actions in the central and peripheral nervous system
17. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
18. A redox-based mechanism for the neuroprotective and neurodestructive effect of nitrite oxide and related nitroso-compounds
19. -
20. Morphological and biochemical maturation of neurones cultured in the absence of glial cells
21. Inhibition of protein kinase C activity and vascular smooth muscle cell growth by D-α-tocopherol
22. Retinoic acid reduces staurosporine-induced apoptotic damage in chick embryonic neurons by suppressing reactive oxygen species production
23. 2 and endothelial oxidative stress
24. 2 in cultured endothelial cells
25. Dihydrorhodamine-123: A fluorescent probe for superoxide generation?
26. 15N-nitrate in biological fluids
27. Melatonin protects primary cultures from cerebellar granule neurons from kainate but not from NMDA excitotoxicity
28. -), superoxide dismutases, and related matters
29. A radical hypothesis for neurodegeneration
30. Melatonin: A potent, endogenous hydroxyl radical scavenger
31. Flow cytometric measurement of the respiratory burst activity of phagocytes using dihydrorhodamine-123
32. - production in human macrophages
33. 2 on the growth, secretion, and metabolism of hybridoma cells in culture
34. Melatonin is a scavenger of peroxynitrite
35. Oxidative stress and neurodegenerative disorders
36. Peroxyl radical trapping reactions of α-tocopherol in biomimetic systems. Vitamin E in health and disease
37. Oxygen radicals and the nervous tissue
38. Creatine increases survival and suppresses seizures in the hypoxic immature rat
39. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate
40. Neuroprotective effects of creatine administration against NMDA and malonate toxicity
41. Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease
42. Creatine protects the central respiratory system under anoxic conditions
43. In situ hybridization analysis of CHOT1, a creatine transporter, in the rat central nervous system
44. Glutaric aciduria I: Creatine supplementation restores creatine phosphate in mixed cortex cells incubated with 3-hydroxy-glutarate
45. Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain
46. Melatonin protects neurons from singlet oxygen-induced apoptosis
47. The role of creatine kinase inhibition of mitochondriaI permeability transition
48. Down regulation of NMDA receptor activity in cortical neurons by peroxynitrite. The biology of nitric oxide
49. Acute encephalopathy despite early therapy in a patient with homozygosity for E365K in the glutaryl-CoA dehydrogenase gene