Ca2+ and Na+ dependence of 3-hydroxyglutarate-induced excitotoxicity in primary neuronal cultures from chick embryo telencephalons

Pediatric Research

Volumn 52, Issue 2, 2002, Pages 199-206

  Kölker, Stefan ^a   Köhr, Georg ^a   Ahlemeyer, Barbara ^a   Okun, Jürgen G ^a   Pawlak, Verena ^a   Hörster, Friederike ^a   Mayatepek, Ertan ^a   Krieglstein, Josef ^a   Hoffmann, Georg F ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYGLUTARATE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CALCIUM; FURA 2; GLUTARIC ACID DERIVATIVE; GLUTARYL COENZYME A DEHYDROGENASE; LITHIUM; MEGLUMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECOMBINANT RECEPTOR; SODIUM; UNCLASSIFIED DRUG; 3 HYDROXYGLUTARIC ACID; 3-HYDROXYGLUTARIC ACID; ADENOSINE TRIPHOSPHATASE; AMPA RECEPTOR; CARRIER PROTEIN; CATION; CYTOCHROME C OXIDASE; MEMBRANE PROTEIN; MULTIENZYME COMPLEX; NEUROTOXIN; OLIGOMYCIN SENSITIVITY CONFERRING PROTEIN; OLIGOMYCIN SENSITIVITY-CONFERRING PROTEIN; OXIDOREDUCTASE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL MEMBRANE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; ENZYME DEFICIENCY; EXTRACELLULAR CALCIUM; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; NERVE CELL CULTURE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RESPIRATORY CHAIN; SPECTROPHOTOMETRY; TELENCEPHALON; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ELECTRON TRANSPORT; HOMEOSTASIS; KIDNEY; METABOLISM; NERVE CELL;

ADENOSINETRIPHOSPHATASE; ANIMAL; CALCIUM; CATIONS; CELLS, CULTURED; CHICK EMBRYO; CYTOCHROME-C OXIDASE; ELECTRON TRANSPORT; GLUTARATES; HOMEOSTASIS; HUMAN; KIDNEY; MEMBRANE PROTEINS; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; NEURONS; NEUROTOXINS; OXIDOREDUCTASES; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; SODIUM; SUCCINATE DEHYDROGENASE; SUPPORT, NON-U.S. GOV'T; TELENCEPHALON; UBIQUINOL-CYTOCHROME-C REDUCTASE; ADENOSINE TRIPHOSPHATASES; ANIMALS; CARRIER PROTEINS; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; HUMANS;

EID: 0035992221     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000023176.89966.45     Document Type: Article

References (56)

1. Glutaric aciduria: Inherited deficiency of glutaryl CoA dehydrogenase activity
2. Glutaryl-CoA dehydrogenase mutations in glutaric acidemia (type I): Review and report of thirty novel mutations
3. Mutation analysis in glutaric aciduria type I
4. Assignment of human glutaryl-CoA dehydrogenase gene (GCDH) to the short arm of chromosome 19 (19p13.2) by in situ hybridization and somatic cell hybrid analysis
5. 3H-labelled glutaryl-CoA: Application in the genotyping of the glutaryl-CoA dehydrogenase locus
6. Clinical course, early diagnosis, treatment, and prevention of disease in glutaryl-CoA dehydrogenase deficiency
7. Age at symptom onset predicts severity of motor impairment and clinical outcome of glutaric acidemia type I
8. CT and MR of the brain in glutaric aciduria type I: A review of 59 published cases and a report of 5 new patients
9. Glutaric aciduria type I: Pathomechanisms of neurodegeneration
10. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: A new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency
11. Excitatory amino acids as final common pathway for neurologic disorders
12. Molecular mechanisms of calcium-dependent excitotoxicity
13. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons
14. Alternative excitotoxic hypothesis
15. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
16. Intrastriatal administration of 3-hydroxyglutaric acid induces convulsions and excitotoxic lesions in rats
17. Contribution of reactive oxygen species to 3-hydroxyglutarate neurotoxicity in primary neuronal cultures from chick embryo telencephalons
18. NMDA receptor channels: Subunit-specific potentiation by reducing agents
19. 2+ extrusion in protection against neuronal excitotoxcitiy
20. 2+ concentration increases in cultured rat forebrain neurons
21. +
22. 2+ indicators with greatly improved fluorescence properties
23. 3-Ureidopropionate contributes to the neuropathology of 3-ureidopropionase deficiency and severe propionic aciduria: A hypothesis
24. Protein measurement with the folin phenol reagent
25. Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase)
26. Preparation and properties of succinate dehydrogenase coenzyme Q reductase (complex II)
27. Isolation of ATPase I, the proton pump of chromatin-granule membranes
28. Bovine cytochrome c oxidases, purified from heart, skeletal muscle, liver and kidney, differ in the small subunits but show the same reaction kinetics with cytochrome c
29. Role of deprotonation events in ubihydroquinone:cytochrome c oxidoreductase from bovine heart and yeast mitochondria
30. The physiology of excitatory amino acids in the vertebrate central nervous system
31. Ionic dependence of glutamate neurotoxicity
32. Defects in the mitochondrial energy metabolism outside the respiratory chain and the pyruvate dehydrogenase
33. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
34. Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system
35. NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum
36. Glutaric aciduria: Biochemical and morphological considerations
37. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration
38. Inhibition of brain glutamate decarboxylase by glutarate, glutaconate, and beta-hydroxyglutarate: Explanation of the symptoms in glutaric aciduria type I?
39. Amino acids as central nervous system transmitters: The influence of ions, amino acid analogues, and ontogeny on transport systems for L-glutamic and L-aspartic acids and glycine into central nervous synaptosomes of the rat
40. 3H] glutamate binding to plasma membranes from brain of young rats by glutaric acid in vitro
41. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
42. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
43. A calcium microdomain near NMDA receptors: On switch for ERK-dependent synapse-to-nucleus communication
44. Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors
45. +, and adenosine triphosphate in isolated brain synaptosomes
46. Chronic treatment with glutaric acid induces partial tolerance to excitotoxicity in neuronal cultures from chick embryo telencephalons
47. Magnesium gates glutamate-activated channels in mouse cerebral neurones
48. Gain control of NMDA-receptor currents by intracellular sodium
49. Potentiation of 3-hydroxyglutarate neurotoxicity following induction of astrocytic iNOS in neonatal rat hippocampal cultures
50. AMPA, kainate and NMDA ionotropic glutamate receptor expression-an in situ hybridization atlas
51. High affinity glutamate transporters: Regulation of expression and activity
52. Early postnatal development of the rat corticostriatal pathway: An anterograde axonal tracing study using biocytin pellets
53. Glutaric aciduria type I: An atypical presentation together with some observations upon treatment and the possible cause of cerebral damage
54. Hypothesis: A role for quinolinic acid in the neuropathology of glutaric aciduria type I
55. Diagnosis and management of glutaric aciduria type I