Chronic treatment with glutaric acid induces partial tolerance to excitotoxicity in neuronal cultures from chick embryo telencephalons

Journal of Neuroscience Research

Volumn 68, Issue 4, 2002, Pages 424-431

  Klker, Stefan ^a   Okun, Jrgen G ^b   Ahlemeyer, Barbara ^b   Wyse, Angela T S ^c   Hrster, Friederike ^d   Wajner, Moacir ^e   Kohlmller, Dirk ^f   Mayatepek, Ertan ^f   Krieglstein, Josef ^g   Hoffmann, Georg F ^g  

^a Department of Tropical Medicine ^*  (United States)

^b DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d RESEARCH AND DEVELOPMENT   (Australia)

^e College of Chemistry and Molecular Engineering ^*  (China)

^f UNIVERSITY OF SHEFFIELD   (United Kingdom)

^g UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Calcium; Glutaryl CoA dehydrogenase; Na+ K+ ATPase; NMDA receptor; Reactive oxygen species; Respiratory chain

Indexed keywords

3 HYDROXYGLUTARIC ACID; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); FATTY ACID; GLUTARIC ACID; GLUTARIC ACID DERIVATIVE; GLUTARYL COENZYME A DEHYDROGENASE; GLUTATHIONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; REACTIVE OXYGEN METABOLITE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN ATROPHY; BRAIN DEGENERATION; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME DEFICIENCY; FATTY ACID OXIDATION; MEMBRANE STEADY POTENTIAL; MITOCHONDRIAL RESPIRATION; NERVE CELL CULTURE; NERVE CELL LESION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; TELENCEPHALON;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL CULTURE TECHNIQUES; CHICK EMBRYO; DOWN-REGULATION; DRUG TOLERANCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTARATES; MITOCHONDRIA; NA(+)-K(+)-EXCHANGING ATPASE; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE; TELENCEPHALON;

EID: 0037093668     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10189     Document Type: Article

References (37)

1. Activity-dependent regulation of n-methyl-D-aspartate receptor subunits expression in cerebellar granule cells
2. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
3. Role of deprotonation events in ubihydroquinone: Cytochrome c oxidoreductase from bovine heart and yeast mitochondria
4. CT and MR of the brain in glutaric acidemia type I: A review of 59 published cases and a report of five new patients
5. Prolonged inhibition of glutamate reuptake downregulates NMDA receptor functions in cultured cerebellar granule cells
6. 2+/calmodulin kinase inhibitor KN93
7. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
8. Mitochondrial production of reactive oxygen species in cortical neurons after exposure to n-methyl-D-aspartate
9. Glutaric aciduria type I: Ultrasonographic demonstration of early signs
10. High affinity glutamate transporters: Regulation of expression and activity
11. Glutaric aciduria: Inherited deficiency of glutaryl-CoA dehydrogenase activity
12. Glutaric aciduria: Biochemical and morphologic considerations
13. Glutaryl-CoA dehydrogenase mutations in glutaric acidemia (type I): Review and report of thirty novel mutations
14. The NMDA receptor subunit NR2B of neonatal rat brain: Complex formation and enrichment in axonal growth cones
15. Glutaryl-CoA dehydrogenase deficiency: A distinct encephalopathy
16. Clinical course, early diagnosis, treatment, and prevention of disease in glutaryl-CoA dehydrogenase deficiency
17. Cloned glutamate receptors
18. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: A new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency
19. Contribution of reactive oxygen species to 3-hydroxyglutarate neurotoxicity in primary neuronal cultures from chick embryo telencephalons
20. Potentiation of 3-hydroxyglutarate neurotoxicity following induction of astrocytic iNOS in neonatal rat hippocampal cultures
21. 3-Ureidopropionate contributes to the neuropathology of 3-ureidopropionate deficiency and severe propionic aciduria: A hypothesis
22. Modulation of neuronal migration by NMDA receptors
23. Contributory mechanisms in the causation of neurodegenerative disorders
24. Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid
25. Protein measurement with the folin phenol reagent
26. Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH: Ubiquinone oxidoreductase)
27. Assembly with the NR1 subunit is required for surface expression of NK3A-containing NMDA receptors
28. 3H] glutamate binding to plasma membranes from brain of young rats by glutaric acid in vitro
29. Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-κB
30. Characterization of agonist-induced downregulation of NMDA receptors in cerebellar granule cell cultures
31. Increased hypoxic tolerance by chemical inhibition of oxidative phosphorylation-chemical preconditioning
32. Molecular mechanisms of calcium-dependent excitotoxicity
33. Inhibition of glutamate decarboxylase by glutarate, glutaconate, and beta-hydroxyglutarate: Explanation of the symptoms in glutaric aciduria?
34. Glutaric aciduria type I: Pathomechanism of neurodegeneration
35. The use of organotypic tissue culture for study of amino acid neurotoxicity and its antagonism in mammalian CNS
36. +-ATPase from rat brain cortex by propionic acid
37. Calmodulin mediates calcium-dependent inactivation of n-methyl-D-aspartate receptors