Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: Evidence for the lysosomal degradation of altered tau in human brain?

Neuroscience Letters

Volumn 284, Issue 3, 2000, Pages 187-189

  Ikeda, Kenji ^a   Akiyama, Haruhiko ^a   Arai, Tetsuaki ^a   Kondo, Hiromi ^a   Haga, Chie ^a   Tsuchiya, Kuniaki ^b   Yamada, Shigeo ^c   Murayama, Shigeo ^c   Hori, Akira ^d  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOKYO METROPOLITAN MATSUZAWA HOSPITAL   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Alz 50; Infarction; Ischemia; Lysosomes; Tau

Indexed keywords

MONOCLONAL ANTIBODY ALZ 50; TAU PROTEIN;

AGED; ARTICLE; BRAIN INFARCTION; CELL GRANULE; CLINICAL ARTICLE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LYSOSOME; NERVE CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; ANTIGENS; BRAIN ISCHEMIA; CEREBRAL CORTEX; CEREBRAL INFARCTION; CYTOPLASMIC GRANULES; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOFUSCIN; LYSOSOMES; MICROSCOPY, IMMUNOELECTRON; NEURONS; TAU PROTEINS; TIME FACTORS;

EID: 0034725178     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01009-0     Document Type: Article

References (7)

1. Courtoy P.J., Picton D.H., Farquar M.G. Resolution and limitations of the immunoperoxidase procedure in the localization of extracellular matrix antigens. J. Histochem. Cytochem. 31:1983;945-951.
2. Dewar D., Graham D.I., Teasdale G.M., McCulloch J. Alz-50 and ubiquitin immunoreactivity is induced by permanent focal cerebral ischaemia in the cat. Acta Neuropathol. 86:1993;623-629.
3. Geddes J.W., Schwab C., Craddock S., Wilson J.L., Pettigrew L.C. Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia. J. Cereb. Blood Flow Metab. 14:1994;554-564.
4. Ikeda K., Akiyama H., Arai T., Nishimura T. Glial tau pathology in neurodegenerative diseases: their nature and comparison with neuronal tangles. Neurobiol. Aging. 19:1998;85-91.
5. Ikeda K., Akiyama H., Arai T., Kondo H., Haga C., Iritani S., Tuchiya K. Alz 50/Gallyas positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains. Neurosci. Lett. 258:1998;113-116.
6. Pettigrew L.C., Holtz M.L., Craddock S.D., Minger S.L., Hall N., Geddes J.W. Microtubular proteolysis in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16:1996;1189-1202.
7. Uchihara T., Tsuchiya K., Kondo H., Hayama T., Ikeda K. Widespread appearance of Alz-50 immunoreactive neurons in the human brain with cerebral infarction. Stroke. 26:1995;2145-2148.