Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells

Toxicology and Applied Pharmacology

Volumn 199, Issue 3, 2004, Pages 332-343

  Huan, Jian Ya ^a   Streicher, John M ^a   Bleyle, Lisa A ^a   Koop, Dennis R ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

CYP2B1; CYP2E1; Cytochrome P450; P450; Proteasome; Protein degradation; Proteolysis; Ubiquitin

Indexed keywords

BENZYL DERIVATIVE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BREFELDIN A; CALPASTATIN; CYTOCHROME P450 2B1; CYTOCHROME P450 2E1; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HERBIMYCIN; LACTACYSTIN; LYSINE; N BENZYLOXYCARBONYLLEUCYLLEUCYLNORVALINAL; PROTEASOME INHIBITOR; RADICICOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; TETRACYCLINE; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HALF LIFE TIME; HELA CELL; HUMAN; HUMAN CELL; LYSOSOME; MOLECULAR WEIGHT; MUTAGENESIS; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STATISTICAL SIGNIFICANCE; TEMPERATURE;

ANIMALS; CALCIUM; CALPAIN; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTEINE ENDOPEPTIDASES; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP2E1; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VECTORS; HEAT; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MULTIENZYME COMPLEXES; MUTAGENESIS; PROTEASOME ENDOPEPTIDASE COMPLEX; RABBITS; RATS; TETRACYCLINE; UBIQUITIN;

CRICETINAE; CRICETULUS GRISEUS;

EID: 4444283077     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.12.019     Document Type: Article

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