메뉴 건너뛰기




Volumn 59, Issue 16, 1999, Pages 3935-3940

Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ANSAMYCIN DERIVATIVE; GELDANAMYCIN; TRANSCRIPTION FACTOR AP 1;

EID: 0033566822     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (37)

References (42)
  • 1
    • 0017977265 scopus 로고
    • Definitive evidence for hypoxic cells influencing cure in cancer therapy
    • Bush, R. S., Jenkin, R. D., and Allt, W. E. C. Definitive evidence for hypoxic cells influencing cure in cancer therapy. Br. J. Cancer, 37 (Suppl. III): 302-306, 1978.
    • (1978) Br. J. Cancer , vol.37 , Issue.SUPPL. III , pp. 302-306
    • Bush, R.S.1    Jenkin, R.D.2    Allt, W.E.C.3
  • 2
    • 0021276479 scopus 로고
    • Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis and a survey of existing data
    • Moulder, J. I., and Rockwell, S. Hypoxic fractions of solid tumors: experimental techniques, methods of analysis and a survey of existing data. Int. J. Radiat. Oncol. Biol. Phys., 10: 695-112, 1984.
    • (1984) Int. J. Radiat. Oncol. Biol. Phys. , vol.10 , pp. 695-1112
    • Moulder, J.I.1    Rockwell, S.2
  • 3
    • 0028206173 scopus 로고
    • Effects of hypoxia upon detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells
    • O'Dwyer, P. J., Yao, K-S., Ford, P., Godwin, A. K., and Clayton, M. Effects of hypoxia upon detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells. Cancer Res., 54: 3082-3087, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3082-3087
    • O'Dwyer, P.J.1    Yao, K.-S.2    Ford, P.3    Godwin, A.K.4    Clayton, M.5
  • 4
    • 0029052835 scopus 로고
    • Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines: Changes in transcription factor expression and function
    • Yao, K-S., Godwin, A. K., Johnson, S., Ozols, R. F., O'Dwyer, P. J., and Hamilton, T. C. Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines: changes in transcription factor expression and function. Cancer Res., 55:4367-4374, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4367-4374
    • Yao, K.-S.1    Godwin, A.K.2    Johnson, S.3    Ozols, R.F.4    O'Dwyer, P.J.5    Hamilton, T.C.6
  • 5
    • 0028978712 scopus 로고
    • Involvement of NF-κB in the induction of NAD(P)H: Quinone oxidoreductase (DT-diaphorase) by hypoxia, oltipraz and mitomycin C
    • Yao, K-S., and O'Dwyer, P. J. Involvement of NF-κB in the induction of NAD(P)H: quinone oxidoreductase (DT-diaphorase) by hypoxia, oltipraz and mitomycin C. Biochem. Pharmacol., 49: 275-282, 1995.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 275-282
    • Yao, K.-S.1    O'Dwyer, P.J.2
  • 8
    • 0030898417 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways
    • Robinson, M. J., and Cobb, M. H. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol., 9: 180-186, 1997.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 180-186
    • Robinson, M.J.1    Cobb, M.H.2
  • 9
    • 0030982641 scopus 로고    scopus 로고
    • The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase
    • Pratt, W. B. The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. Annu. Rev. Pharmacol. Toxicol., 37: 297-326, 1997.
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 297-326
    • Pratt, W.B.1
  • 10
    • 0028786332 scopus 로고
    • Disruption of Raf-1-hsp90 molecular complex results in destabilizabon of Raf-1 and loss of Raf-1-Ras association
    • Schulte, T. W., Blagosklonny, M. V., Ingui, C., and Neckers, L. Disruption of Raf-1-hsp90 molecular complex results in destabilizabon of Raf-1 and loss of Raf-1-Ras association. J. Biol. Chem., 270: 24585-24588, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24585-24588
    • Schulte, T.W.1    Blagosklonny, M.V.2    Ingui, C.3    Neckers, L.4
  • 11
    • 0027935756 scopus 로고
    • Interaction of Ras and Raf in intact cells upon extracellular stimulation
    • Hallberg, B., Rayter, S. I., and Downward, J. Interaction of Ras and Raf in intact cells upon extracellular stimulation. J. Biol. Chem., 269: 3913-3916, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3913-3916
    • Hallberg, B.1    Rayter, S.I.2    Downward, J.3
  • 12
    • 0031054517 scopus 로고    scopus 로고
    • The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase
    • Hallberg, B., Stancato, S. I., Silverstein, A. M., Owens-Grillo, J. K., Chow, Y-H., Jove, R., and Pratt, W. B. The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase. J. Biol. Chem., 272: 4013-4020, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4013-4020
    • Hallberg, B.1    Stancato, S.I.2    Silverstein, A.M.3    Owens-Grillo, J.K.4    Chow, Y.-H.5    Jove, R.6    Pratt, W.B.7
  • 13
    • 0031895351 scopus 로고    scopus 로고
    • The hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors
    • Pratt, W. B. The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors. Proc. Soc. Exp. Biol. Med., 217: 420-434, 1998.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.217 , pp. 420-434
    • Pratt, W.B.1
  • 15
    • 0029812759 scopus 로고    scopus 로고
    • Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosin kinase induced by geldanamycin
    • Mimnaugh, E. G., Chavany, C., and Neckers, L. Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosin kinase induced by geldanamycin. J. Biol. Chem., 271: 22796-22801, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 22796-22801
    • Mimnaugh, E.G.1    Chavany, C.2    Neckers, L.3
  • 16
    • 0030878952 scopus 로고    scopus 로고
    • Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo
    • Whitesell, L., Sutphin, P., Wen, G. A., Schulte, T., Blagosklonny, M. V., and Neckers, L. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene 14: 2809-2816, 1997.
    • (1997) Oncogene , vol.14 , pp. 2809-2816
    • Whitesell, L.1    Sutphin, P.2    Wen, G.A.3    Schulte, T.4    Blagosklonny, M.V.5    Neckers, L.6
  • 17
    • 0031590456 scopus 로고    scopus 로고
    • Geldanamycin-induced destabilization of Raf-1 involves the proteasome
    • Schulte, T. W., Won, G. A., and Neckers, L. M. Geldanamycin-induced destabilization of Raf-1 involves the proteasome. Biochem. Biophys. Res. Comun., 239: 655-659, 1997.
    • (1997) Biochem. Biophys. Res. Comun. , vol.239 , pp. 655-659
    • Schulte, T.W.1    Won, G.A.2    Neckers, L.M.3
  • 18
    • 0027936404 scopus 로고
    • Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia
    • Yao, K-S., Xanthoudakis, S., Curran, T., and O'Dwyer, P. J. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol. Cell. Biol., 14: 5997-6003, 1994.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5997-6003
    • Yao, K.-S.1    Xanthoudakis, S.2    Curran, T.3    O'Dwyer, P.J.4
  • 19
    • 0029992018 scopus 로고    scopus 로고
    • Early responses of siHa human squamous carcinoma cells to hypoxic signals: Evidence of parallel activation of NF-κB and AP-1 transcriptional complexes
    • Laderoute, K. R., Calaoagan, J. M., Mendonca, H. L., Ausserer, W. A., Chen, E. Y., Giaccia, A. J., and Sutherland, R. M. Early responses of SiHa human squamous carcinoma cells to hypoxic signals: evidence of parallel activation of NF-κB and AP-1 transcriptional complexes. Int. J. Oncology, 8: 875-882, 1996.
    • (1996) Int. J. Oncology , vol.8 , pp. 875-882
    • Laderoute, K.R.1    Calaoagan, J.M.2    Mendonca, H.L.3    Ausserer, W.A.4    Chen, E.Y.5    Giaccia, A.J.6    Sutherland, R.M.7
  • 21
    • 0030866226 scopus 로고    scopus 로고
    • Hypoxia induces c-fos transcription via mitogen-activated protein kinase-dependent pathway
    • Muller, J. M., Krauss, B., Kaltschmidt, C., Baeuerle, P. A., and Rupec, R. A. Hypoxia induces c-fos transcription via mitogen-activated protein kinase-dependent pathway. J. Biol. Chem., 272: 23435-23439, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23435-23439
    • Muller, J.M.1    Krauss, B.2    Kaltschmidt, C.3    Baeuerle, P.A.4    Rupec, R.A.5
  • 22
    • 0027257482 scopus 로고
    • Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes
    • Webster, K. A., Discher, D. J., and Bishorpic, N. H. Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes. J. Biol. Chem., 268: 16852-16858, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 16852-16858
    • Webster, K.A.1    Discher, D.J.2    Bishorpic, N.H.3
  • 23
    • 0030044744 scopus 로고    scopus 로고
    • Hypoxia, and hypoxia/ reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes
    • Seko, Y., Tobe, K., Ueki, K., Kadowaki, T., and Yazaki, Y. Hypoxia, and hypoxia/ reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes. Circ. Res., 78: 82-90, 1996.
    • (1996) Circ. Res. , vol.78 , pp. 82-90
    • Seko, Y.1    Tobe, K.2    Ueki, K.3    Kadowaki, T.4    Yazaki, Y.5
  • 24
    • 0031590460 scopus 로고    scopus 로고
    • Hypoxia, hypoxia/reoxygenation activate p65PAK, p38 mitogan-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes
    • Seko, Y., Takahashi, N., Tobe, K., Kadowaki, T., and Yazaki, Y. Hypoxia, and hypoxia/reoxygenation activate p65PAK, p38 mitogan-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes. Biochem. Biophys. Res. Comun., 239: 840-844, 1997.
    • (1997) Biochem. Biophys. Res. Comun. , vol.239 , pp. 840-844
    • Seko, Y.1    Takahashi, N.2    Tobe, K.3    Kadowaki, T.4    Yazaki, Y.5
  • 25
    • 0032541029 scopus 로고    scopus 로고
    • P42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts
    • Milanini, J., Vinals, F., Pouyssegur, J., and Pages, G. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J. Biol. Chem., 273: 18165-18172, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 18165-18172
    • Milanini, J.1    Vinals, F.2    Pouyssegur, J.3    Pages, G.4
  • 26
    • 0027282295 scopus 로고
    • In vivo protein-DNA interaction at the c-jun promoter: Preferred complexes mediate the UV response
    • Rozek, D., and Pfeifer, G. P. In vivo protein-DNA interaction at the c-jun promoter: preferred complexes mediate the UV response. Mol. Cell. Biol., 13: 5490-5499, 1993.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5490-5499
    • Rozek, D.1    Pfeifer, G.P.2
  • 27
    • 0029030855 scopus 로고
    • ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents
    • Van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlih, P., and Angel, P. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J., 14: 1798-1811, 1991.
    • (1991) EMBO J. , pp. 1798-1811
    • Van Dam, H.1    Wilhelm, D.2    Herr, I.3    Steffen, A.4    Herrlih, P.5    Angel, P.6
  • 28
    • 0029585369 scopus 로고
    • Ishemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from c-jun promoter
    • Morooka, H., Bonventre, J. V., Pombo, C. M., Kyriakis, J. M., and Force, T. Ishemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from c-jun promoter. J. Biol. Chem., 270: 39084-30092, 1995.
    • (1995) J. Biol. Chem. , pp. 39084-130092
    • Morooka, H.1    Bonventre, J.V.2    Pombo, C.M.3    Kyriakis, J.M.4    Force, T.5
  • 30
    • 0024550271 scopus 로고
    • Inhibition of c-myc gene expression in murine lymphoblastome cells by geldanamycin and herbimycin, antibiotics of benzoquinoid ansamycin group
    • Yamaki, H., Iguchi-Agira, S. M., and Agira, H. Inhibition of c-myc gene expression in murine lymphoblastome cells by geldanamycin and herbimycin, antibiotics of benzoquinoid ansamycin group. J. Antibiotics, 42: 604-610, 1989.
    • (1989) J. Antibiotics , vol.42 , pp. 604-610
    • Yamaki, H.1    Iguchi-Agira, S.M.2    Agira, H.3
  • 31
    • 0029031618 scopus 로고
    • Influence of protein tyrosine phosphorylation on the expression of the c-myc oncogene in cancer of the large bowel
    • Heruth, D. P., Wetmore, L. A., Leyva, A., and Rothberg, P. G. Influence of protein tyrosine phosphorylation on the expression of the c-myc oncogene in cancer of the large bowel. J. Cell. Biochem., 58: 83-94, 1995.
    • (1995) J. Cell. Biochem. , vol.58 , pp. 83-94
    • Heruth, D.P.1    Wetmore, L.A.2    Leyva, A.3    Rothberg, P.G.4
  • 32
    • 0031025859 scopus 로고    scopus 로고
    • Effects of the tyrosine-kinase inhibitor geldanamycin on ligand-induced Her-2/neu activation, receptor expression and proliferation of Her-positive malignant cell lines
    • Hartmann, F. Horak, E. M. Cho, C. Lupu, R. Bolen, J. B., Stetler-Stevenson, M. A., Pfreundschuh, M., Waldmann, T. A., and Horak, I. D. Effects of the tyrosine-kinase inhibitor geldanamycin on ligand-induced Her-2/neu activation, receptor expression and proliferation of Her-positive malignant cell lines. Int. J. Cancer, 70: 221-229, 1997.
    • (1997) Int. J. Cancer , vol.70 , pp. 221-229
    • Hartmann, F.1    Horak, E.M.2    Cho, C.3    Lupu, R.4    Bolen, J.B.5    Stetler-Stevenson, M.A.6    Pfreundschuh, M.7    Waldmann, T.A.8    Horak, I.D.9
  • 33
    • 0032787306 scopus 로고    scopus 로고
    • The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase
    • Ochel, H. J., Schulte, T. W., Nguyen, P., Trepel, J., and Neckers, L. The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase. Mol. Genet. Metab., 66: 24-30, 1999.
    • (1999) Mol. Genet. Metab. , vol.66 , pp. 24-30
    • Ochel, H.J.1    Schulte, T.W.2    Nguyen, P.3    Trepel, J.4    Neckers, L.5
  • 34
    • 0026735864 scopus 로고
    • Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition
    • Whitesell, L., Shifrin, S. D., Schwab, G., and Neckers, L. M. Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition. Cancer Res., 52: 1721-1728, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 1721-1728
    • Whitesell, L.1    Shifrin, S.D.2    Schwab, G.3    Neckers, L.M.4
  • 35
    • 0031044561 scopus 로고    scopus 로고
    • MEKKs, GSKs, PAKs, TAKs, and Tpls: Upstream regulators of the c-Jun amino-terminal kinases?
    • Fanger, G. R., Gerwins, P., Widmann, C., Jarpe, M. B., and Johnson, G. L. MEKKs, GSKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases? Curr. Opin. Genet. Dev., 7: 67-74, 1997.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 67-74
    • Fanger, G.R.1    Gerwins, P.2    Widmann, C.3    Jarpe, M.B.4    Johnson, G.L.5
  • 36
    • 0031586616 scopus 로고    scopus 로고
    • Geldanamycin prevents nuclear translocation of mutant p53
    • Dasgupta, G., and Momand, J. Geldanamycin prevents nuclear translocation of mutant p53. Exp. Cell Res., 237: 29-37, 1997.
    • (1997) Exp. Cell Res. , vol.237 , pp. 29-37
    • Dasgupta, G.1    Momand, J.2
  • 37
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn, H. F., and Poyton, R. O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev., 76: 839-885, 1996.
    • (1996) Physiol. Rev. , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 38
    • 0031823016 scopus 로고    scopus 로고
    • The molecular basis of the hypoxia response pathway: Tumor hypoxia as a therapy target
    • Blancher, C., and Harris, A. L. The molecular basis of the hypoxia response pathway: tumor hypoxia as a therapy target. Cancer Metastasis Rev., 17: 187-194, 1998.
    • (1998) Cancer Metastasis Rev. , vol.17 , pp. 187-194
    • Blancher, C.1    Harris, A.L.2
  • 39
    • 0031870833 scopus 로고    scopus 로고
    • The pivotal role of VEGF in tumor angiogenesis: Molecular facts and therapeutic opportunities
    • Siemeister, G., Baron-Martiny, G., and Marme, D. The pivotal role of VEGF in tumor angiogenesis: molecular facts and therapeutic opportunities. Cancer Metastasis Rev., 17: 241-248, 1998.
    • (1998) Cancer Metastasis Rev. , vol.17 , pp. 241-248
    • Siemeister, G.1    Baron-Martiny, G.2    Marme, D.3
  • 40
    • 0030713446 scopus 로고    scopus 로고
    • Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia-induced transcriptional activation of vascular endothelial growth factor expression in c6 glioma cells
    • Damert, A., Ikeda, E., and Risau, W. Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia-induced transcriptional activation of vascular endothelial growth factor expression in c6 glioma cells. Biochem. J., 327: 419-423, 1997.
    • (1997) Biochem. J. , vol.327 , pp. 419-423
    • Damert, A.1    Ikeda, E.2    Risau, W.3
  • 41
    • 0030920914 scopus 로고    scopus 로고
    • The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin
    • Potapova, O., Haghighi, A., Bost, F., Liu, C., Birrer, M. J., Gjerset, R., and Mercola, D. The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J. Biol. Chem., 272: 14041-14044, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14041-14044
    • Potapova, O.1    Haghighi, A.2    Bost, F.3    Liu, C.4    Birrer, M.J.5    Gjerset, R.6    Mercola, D.7
  • 42
    • 0031875042 scopus 로고    scopus 로고
    • The benzoquinone ansamycin 17-allyloamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
    • Schulte, T. W., and Neckers, L. M. The benzoquinone ansamycin 17-allyloamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother. Pharmacol., 42: 273-279, 1998.
    • (1998) Cancer Chemother. Pharmacol. , vol.42 , pp. 273-279
    • Schulte, T.W.1    Neckers, L.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.