Protein surface-assisted enhancement in the binding affinity of an inhibitor for recombinant human carbonic anhydrase-II

Journal of the American Chemical Society

Volumn 126, Issue 35, 2004, Pages 10875-10883

  Banerjee, Abir L ^a   Swanson, Michael ^a   Roy, Bidhan C ^a   Jia, Xiao ^a   Haldar, Manas K ^a   Mallik, Sanku ^a   Srivastava, D K ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITY; HISTIDINE RESIDUES; TETHERS;

BENZENE; DRUG DOSAGE; ENZYMES; GLYCOLS; TETHERLINES;

PROTEINS;

BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; COPPER; DIGLYCINE; ENZYME; HISTIDINE; ISOENZYME; PROTEIN; RECOMBINANT CARBONATE DEHYDRATASE II; RECOMBINANT ENZYME; TRIETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; ENZYME ACTIVE SITE; KINETICS; LIGAND BINDING;

BINDING SITES; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMINO ACIDS; KINETICS; MODELS, MOLECULAR; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; SULFONAMIDES; SURFACE PROPERTIES;

EID: 4444278825     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja047557p     Document Type: Article

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