A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2',5'- dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (fidarestat): Its absolute configuration and interactions with the aldose reductase by X-ray crystallography

Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2000, Pages 2479-2483

  Oka, Mitsuru ^a,b   Matsumoto, Yukiharu ^b   Sugiyama, Shigeru ^c   Tsuruta, Nobuaki ^b   Matsushima, Masaaki ^a,d  

^a Rational Drug Design Laboratories   (Japan)

^b SANWA KAGAKU KENKYUSHO CO LTD   (Japan)

^c MARUWA Foods Industries Inc   (Japan)

^d ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; FIDARESTAT;

ARTICLE; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

ALDEHYDE REDUCTASE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; IMIDAZOLIDINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 0033920645     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990502r     Document Type: Article

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