Modeling the binding affinities of β-secretase inhibitors: Application to subsite specificity

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 19, 2004, Pages 4843-4846

  Rajamani, Ramkumar ^a   Reynolds, Charles H ^a  

^a Johnson Johnson Pharmaceutical R D   (United States)

Author keywords

Secretase; BACE; Binding affinity; Modeling; Structure based design

Indexed keywords

BETA SECRETASE INHIBITOR; ETHYLENE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; STATISTICAL MODEL;

AMYLOID PRECURSOR PROTEIN SECRETASES; BINDING SITES; DRUG DESIGN; ENDOPEPTIDASES; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4444231432     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.07.044     Document Type: Article

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