Calculation of the binding affinity of β-secretase inhibitors using the linear interaction energy method

Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2003, Pages 2074-2082

  Tounge, Brett A ^a   Reynolds, Charles H ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SECRETASE; ENZYME INHIBITOR; OM 00 3; OM 99 2; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; MATHEMATICAL COMPUTING; MOLECULAR MODEL; SIMULATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; ELECTRICITY; ENDOPEPTIDASES; ENZYME INHIBITORS; LIGANDS; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; THERMODYNAMICS;

EID: 0038704856     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020513b     Document Type: Article

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