Exportin 7 defines a novel general nuclear export pathway

EMBO Journal

Volumn 23, Issue 16, 2004, Pages 3227-3236

  Mingot, José Manuel ^a   Bohnsack, Markus T ^a   Jäkle, Ursula ^a   Görlich, Dirk ^a,b  

^a INF 282   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

14 3 3; Nuclear pore complex; P50RhoGAP; RanGTPase; Xpo7

Indexed keywords

CELL NUCLEUS RECEPTOR; CYCLIN DEPENDENT KINASE; EXPORTIN 1; EXPORTIN 7; PROTEIN RANBP16; RAN PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE TRANSPORT; CELL NUCLEUS MEMBRANE; CELL NUCLEUS TRANSPLANTATION; ENZYME SPECIFICITY; EUKARYOTE EVOLUTION; MEDIATOR RELEASE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION;

14-3-3 PROTEINS; ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; BINDING SITES; CELL LINE; CELL NUCLEUS; CLONING, MOLECULAR; DNA-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HUMANS; KARYOPHERINS; LYSINE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; XENOPUS LAEVIS;

ANIMALIA; EUKARYOTA;

EID: 4444229456     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600338     Document Type: Article

References (68)

1. Arighi CN, Hartnell LM, Aguilar RC, Haft CR, Bonifacino JS (2004) Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol 165: 123-133
2. Arts GJ, Fornerod M, Mattaj IW (1998) Identification of a nuclear export receptor for tRNA. Curr Biol 8: 305-314
3. Barrett T, Xiao B, Dodson EJ, Dodson G, Ludbrook SB, Nurmahomed K, Gamblin SJ, Musacchio A, Smerdon SJ, Eccleston JF (1997) The structure of the GTPase-activating domain from p50rhoGAP. Nature 385: 458-461
4. Berg D, Holzmann C, Riess O (2003) 14-3-3 proteins in the nervous system. Nat Rev Neurosci 4: 752-762
5. Bischoff FR, Görlich D (1997) RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors. FEBS Lett 419: 249-254
6. Bogerd HP, Fridell RA, Benson RE, Hua J, Cullen BR (1996) Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol Cell Biol 16: 4207-4214
7. Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Gorlich D (2002) Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J 21: 6205-6215
8. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB (2002) 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol 156: 817-828
9. Calado A, Treichel N, Muller EC, Otto A, Kutay U (2002) Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J 21: 6216-6224
10. Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B (1999) 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401: 616-620
11. Conti E, Izaurralde E (2001) Nucleocytoplasmic transport enters the atomic age. Curr Opin Cell Biol 13: 310-319
12. Englmeier L, Olivo JC, Mattaj IW (1999) Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis. Curr Biol 9: 30-41
13. Erickson JW, Cerione RA (2001) Multiple roles for Cdc42 in cell regulation. Curr Opin Cell Biol 13: 153-157
14. Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420: 629-635
15. Fischer U, Huber J, Boelens WC, Mattaj IW, Lührmann R (1995) The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82: 475-483
16. Fletcher CM, Pestova TV, Hellen CU, Wagner G (1999) Structure and interactions of the translation initiation factor eIF1. EMBO J 18: 2631-2637
17. Fornerod M, Ohno M (2002) Exportin-mediated nuclear export of proteins and ribonucleoproteins. Results Probl Cell Differ 35: 67-91
18. Fornerod M, Ohno M, Yoshida M, Mattaj IW (1997) Crm1 is an export receptor for leucine rich nuclear export signals. Cell 90: 1051-1060
19. Fried H, Kutay U (2003) Nucleocytoplasmic transport: taking an inventory. Cell Mol Life Sci 60: 1659-1688
20. Fu H, Subramanian RR, Masters SC (2000) 14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol 40: 617-647
21. Görlich D, Henklein P, Laskey RA, Hartmann E (1996a) A 41 amino acid motif in importin alpha confers binding to importin beta and hence transit into the nucleus. EMBO J 15: 1810-1817
22. Görlich D, Kutay U (1999) Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 15: 607-660
23. Görlich D, Pante N, Kutay U, Aebi U, Bischoff FR (1996b) Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J 15: 5584-5594
24. Görlich D, Seewald MJ, Ribbeck K (2003) Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation. EMBO J 22: 1088-1100
25. Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (2000) Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell 11: 4105-4116
26. Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B (1997) 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell 1: 3-11
27. Imamoto N (2000) Diversity in nucleocytoplasmic transport pathways. Cell Struct Funct 25: 207-216
28. Izaurralde E, Kutay U, von Kobbe C, Mattaj IW, Görlich D (1997) The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J 16: 6535-6547
29. Jarmolowski A, Boelens WC, Izaurralde E, Mattaj IW (1994) Nuclear export of different classes of RNA is mediated by specific factors. J Cell Biol 124: 627-635
30. Kaffman A, O'Shea EK (1999) Regulation of nuclear localization: a key to a door. Annu Rev Cell Dev Biol 15: 291-339
31. Kalab P, Weis K, Heald R (2002) Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 295: 2452-2456
32. Kose S, Imamoto N, Tachibana T, Shimamoto T, Yoneda Y (1997) Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex. J Cell Biol 139: 841-849
33. Kutay U, Bischoff FR, Kostka S, Kraft R, Görlich D (1997a) Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell 90: 1061-1071
34. Kutay U, Hartmann E, Treichel N, Calado A, Carmo-Fonseca M, Prehn S, Kraft R, Görlich D, Bischoff FR (2000) Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. J Biol Chem 275: 40163-40168
35. Kutay U, Izaurralde E, Bischoff FR, Mattaj IW, Görlich D (1997b) Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J 16: 1153-1163
36. Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Görlich D (1998) Identification of a tRNA-specific nuclear export receptor. Mol Cell 1: 359-369
37. Lancaster CA, Taylor-Harris PM, Self AJ, Brill S, van Erp HE, Hall A (1994) Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases. J Biol Chem 269: 1137-1142
38. Laronga C, Yang HY, Neal C, Lee MH (2000) Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem 275: 23106-23112
39. Lipowsky G, Bischoff FR, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Görlich D (2000) Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. EMBO J 19: 4362-4371
40. Liu D, Bienkowska J, Petosa C, Collier RJ, Fu H, Liddington R (1995) Crystal structure of the zeta isoform of the 14-3-3 protein. Nature 376: 191-194
41. Macara IG (2001) Transport into and out of the nucleus. Microbiol Mol Biol Rev 65: 570-594
42. Majumdar R, Bandyopadhyay A, Maitra U (2003) Mammalian translation initiation factor eIF1 functions with eIF1A and eIF3 in the formation of a spreinitiation complex. J Biol Chem 278: 6580-6587
43. Mattaj IW, Englmeier L (1998) Nucleocytoplasmic transport: the soluble phase. Annu. Rev Biochem 67: 265-306
44. Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (2001) Importin 13: a novel mediator of nuclear import and export. EMBO J 20: 3685-3694
45. Nishi K, Yoshida M, Fujiwara D, Nishikawa M, Horinouchi S, Beppu T (1994) Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J Biol Chem 269: 6320-6324
46. Pestova TV, Kolupaeva VG (2002) The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes Dev 16: 2906-2922
47. Pestova TV, Kolupaeva VG, Lomakin IB, Pilipenko EV, Shatsky IN, Agol VI, Hellen CU (2001) Molecular mechanisms of translation initiation in eukaryotes. Proc Natl Acad Sci USA 98: 7029-7036
48. Rexach M, Blobel G (1995) Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 83: 683-692
49. Ribbeck K, Görlich D (2001) Kinetic analysis of translocation through nuclear pore complexes. EMBO J 20: 1320-1330
50. Ribbeck K, Kutay U, Paraskeva E, Görlich D (1999) The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy. Curr Biol 9: 47-50
51. Ribbeck K, Lipowsky G, Kent HM, Stewart M, Görlich D (1998) NTF2 mediates nuclear import of Ran. EMBO J 17: 6587-6598
52. Richards SA, Lounsbury KM, Carey KL, Macara IG (1996) A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1. J Cell Biol 134: 1157-1168
53. Rogers Jr GW, Komar AA, Merrick WC (2002) eIF4A: the godfather of the DEAD box helicases. Prog Nucleic Acid Res Mol Biol 72: 307-331
54. Schwoebel ED, Talcott B, Cushman I, Moore MS (1998) Ran-dependent signal-mediated nuclear import does not require GTP hydrolysis by Ran. J Biol Chem 273: 35170-35175
55. Seaman MN (2004) Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol 165: 111-122
56. Smith AE, Slepchenko BM, Schaff JC, Loew LM, Macara IG (2002) Systems analysis of Ran transport. Science 295: 488-491
57. Strom AC, Weis K (2001) Importin-beta-like nuclear transport receptors. Genome Biol 2, REVIEWS3008
58. Stüven T, Hartmann E, Görlich D (2003) Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. EMBO J 22: 5928-5940
59. Tschochner H, Hurt E (2003) Pre-ribosomes on the road from the nucleolus to the cytoplasm. Trends Cell Biol 13: 255-263
60. Tzivion G, Avruch J (2002) 14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation. J Biol Chem 277: 3061-3064
61. van Hemert MJ, Niemantsverdriet M, Schmidt T, Backendorf C, Spaink HP (2004) Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3 sigma and 14-3-3 zeta. J Cell Sci 117: 1411-1420
62. van Hemert MJ, Steensma HY, van Heusden GP (2001) 14-3-3 proteins: key regulators of cell division, signalling and apoptosis. BioEssays 23: 936-946
63. Weis K (2003) Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell 112: 441-451
64. Weis K, Dingwall C, Lamond AI (1996) Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J 15: 7120-7128
65. Wen W, Meinkoth JL, Tsien RY, Taylor SS (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell 82: 463-473
66. Wozniak RW, Rout MP, Aitchison JD (1998) Karyopherins and kissing cousins. Trends Cell Biol 8: 184-188
67. Xiao B, Smerdon SJ, Jones DH, Dodson GG, Soneji Y, Aitken A, Gamblin SJ (1995) Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. Nature 376: 188-191
68. Yang HY, Wen YY, Chen CH, Lozano G, Lee MH (2003) 14-3-3 sigma positively regulates p53 and suppresses tumor growth. Mol Cell Biol 23: 7096-7107