Renal expression and urinary concentration of EGF and IL-6 in acutely dysfunctioning kidney transplanted patients

Nephrology Dialysis Transplantation

Volumn 12, Issue 12, 1997, Pages 2687-2693

  Di Paolo, Salvatore ^a   Gesualdo, Loreto ^a   Stallone, Giovanni ^a   Ranieri, Elena ^a   Schena, F Paolo ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Acute graft dysfunction; EGF; IL 6; Kidney transplantation; Renal expression; Urine excretion rate

Indexed keywords

CREATININE; CYCLOSPORIN; EPIDERMAL GROWTH FACTOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 6;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY PROXIMAL TUBULE; KIDNEY TRANSPLANTATION; KIDNEY TUBULE DAMAGE; MALE; NEPHROTOXICITY; PRIORITY JOURNAL; RECIPIENT; URINARY EXCRETION;

EID: 0030695235     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/12.12.2687     Document Type: Article

References (29)

1. Horii Y, Muraguchi A, Iwano M et al. Involvement of IL-6 in mesangial proliferative glomerulonephritis. J Immunol 1989; 143: 3949-3956
2. Coleman D, Ruef C. Interleukin 6: an autocrine regulator of mesangial cell growth. Kidney Int 1992; 41: 604-611
3. Frank J, Engler-Blum G, Rodemann HP, Müller GA. Human tubular cells as a cytokine source: PDGF-B, GM-CSF and IL-6 mRNA expression in vitro. Exp Nephrol 1993; 1: 26-35
4. Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today 1990; 11: 443-449
5. Fukatsu A, Matsuo S, Tamai H, Sakamoto N, Matsuda T, Hirano T. Distribution of interleukin-6 in normal and diseased human kidney. Lab Invest 1991; 65: 61-66
6. Ohta K, Takano N, Seno A et al. Detection and clinical usefulness of urinary interleukin-6 in the diseases of kidney and urinary tract. Clin Nephrol 1992; 38: 185-189
7. Ranieri E, Gesualdo L, Petrarulo F, Schena FP. Urinary IL-6/EGF ratio: a useful prognostic marker of renal damage in IgA nephropathy. Kidney Int 1996; 50: 1990-2001
8. Rall LB, Scott J, Bell GI, Crawford RJ, Penshow JD, Coghland JP. Mouse prepro- epidermal growth factor synthesis by the kidney and other tissues. Nature 1985; 313: 228-231
9. Salido EC, Yen PH, Shapiro LJ, Fisher DA, Barajas L. In situ hybridization of pre-pro epidermal growth factor mRNA in the mouse kidney. Am J Physiol 1989; 256: F632-F638
10. Nouwen EJ, De Broe ME. EGF and TGF-x in the human kidney: identification of octopal cells in the collecting duct. Kidney Int 1994; 45: 1510-1521
11. Gesualdo L, Di Paolo S, Calabrò A et al. Expression of epidermal growth factor and its receptor in normal and diseased human kidney. An immunohistochemical and in situ hybridization study. Kidney Int 1996; 49: 656-665
12. Harris RC. Potential physiologic roles for epidermal growth factor in the kidney. Am J Kidney Dis 1991; 17: 627-630
13. Humes HD, Cieslinski DA, Coimbra TM, Messana JM, Galvao C. Epidermal growth factor enhances renal tubule regeneration and repair and accelerates recovery of renal function in post-ischemic renal failure. J Clin Invest 1989; 84: 1757-1761
14. Coimbra TM, Cieslinski DA, Humes HD. Epidermal growth factor accelerates renal repair in mercuric chloride nephrototoxicity. Am J Physiol 1990; 259: F438-F443
15. Norman J, Tsau YK, Bacay A, Fine LG. Epidermal growth factor (EGF) accelerates recovery from ischemic acute tubular necrosis: Role of the EGF-receptor. Clin Sci 1990; 78: 445-449
16. Taira T, Yoshimura A, Iizuka K, Iwasaki S, Ideura T, Koshikawa S. Urinary epidermal growth factor levels in patients with acute renal failure. Am J Kidney Dis 1993; 22: 656-661
17. Solez K, Axelsen RA, Benediktsson H et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411-422
18. Gesualdo L, Di Paolo S, Milani S et al. Expression of platelet-derived growth factor receptors in normal and diseased human kidney. J Clin Invest 1994; 94: 50-58
19. Stein-Oakley AN, Tzanidis A, Fuller PJ, Jablonski P, Thomson NM. Expression and distribution of epidermal growth factor in acute and chronic renal allograft rejection. Kidney Int 1994; 46: 1207-1215
20. Ivanyi B, Hansen HE, Olsen S. Segmental localization and quantitative characteristics of tubulitis in kidney biopsies from patients undergoing acute rejection. Transplantation 1993; 56: 581-585
21. Mroczkowski B, Reich M. Identification of biologically active epidermal growth factor precursor in human fluids and secretions. Endocrinology 1993; 132: 417-425
22. Jorgensen PE, Kamper AL, Munck O, Strandgaard S, Nexo E. Urinary excretion of epidermal growth factor in living human kidney donors and their recipients. Eur J Clin Invest 1995; 25: 442-446
23. Krams SM, Falco DA, Villanueva JC et al. Cytokine and T cell receptor gene expression at the site of allograft rejection. Transplantation 1992; 53: 151-156
24. Vandenbroecke C, Caillat-Zucman S, Legendre C et al. Differential in situ expression of cytokines in renal allograft rejection. Transplantation 1991; 51: 602-609
25. Raasveld MHM, Weening JJ, Kerst JM, Surachno S, ten Berge RJM. Local production of interleukin-6 during acute rejection in human renal allografts. Nephrol Dial Transplant 1993; 8: 75-78
26. Raasveld MHM, Bloemena E, Wilmink JM, Surachno S, Schellekens PTA, ten Berge RJM. Interleukin-6 and neopterin in renal transplant recipients: a longitudinal study. Transplant Int 1993; 6: 89-94
27. Newstead CG, Lamb WR, Brenchley PEC, Short CD. Serum and urine IL-6 and TNF-α in renal transplant recipients with graft dysfunction. Transplantation 1993; 56: 831-835
28. Van Oers MHJ, Van Der Heyden AAPAM, Aarden LA. Interleukin-6 (IL-6) in serum and urine of renal transplant recipients. Clin Exp Immunol 1988; 71: 314-319
29. Waiser J, Budde K, Katalinic A, Kuerzdorfer M, Rieß R, Neumayer H-H. Interleukin-6 expression after renal transplantation. Nephrol Dial Transplant 1997; 12: 753-759