Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway

Immunology Letters

Volumn 118, Issue 1, 2008, Pages 13-20

  Chen, Jianming ^a   Panchanathan, Ravichandran ^a,b   Choubey, Divaker ^a,b  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Autoimmunity; c Jun AP 1; Interferon inducible Ifi202; JNK; Lupus susceptibility; T cell stimulation

Indexed keywords

ANISOMYCIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CD28 ANTIBODY; CD3 ANTIBODY; CELL ANTIBODY; MESSENGER RNA; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL STRAIN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYBRIDOMA; IFI202 GENE; MALE; MOUSE; NEW ZEALAND BLACK MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEADY STATE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HYBRIDOMAS; I-KAPPA B KINASE; INTERFERON-ALPHA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICE; MICE, INBRED NZB; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; UP-REGULATION;

EID: 43849088828     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2008.02.005     Document Type: Article

References (48)

1. Kotzin B.L. Systemic lupus erythematosus. Cell 85 (1996) 303-306
2. Tsokos G.C., and Kammer G.M. Molecular aberrations in human systemic lupus erythematosus. Mol Med Today 6 (2000) 418-424
3. Jorgensen T.N., Gubbels M.R., and Kotzin B.L. New insights into disease pathogenesis from mouse lupus genetics. Curr Opin Immunol 16 (2004) 787-793
4. Theofilopoulos A.N., Baccala R., Beutler B., and Kono D.H. Type I interferons (α/β) in immunity and autoimmunity. Annu Rev Immunol 23 (2005) 307-336
5. Rider V., and Abdou N.I. Gender differences in autoimmunity: molecular basis for estrogen effects in systemic lupus erythematosus. Int Immunopharmacol 1 (2001) 1009-1024
6. Yacoub Wasef S.Z. Gender differences in systemic lupus erythematosus. Gend Med 1 (2004) 12-17
7. Cohen-Solal J.F., Jeganathan V., Grimaldi C.M., Peeva E., and Diamond B. Sex hormones and SLE: influencing the fate of autoreactive B cells. Curr Top Microbiol Immunol 305 (2006) 67-88
8. Vyse T.J., and Kotzin B.L. Genetic susceptibility to systemic lupus erythematosus. Ann Rev Immunol 16 (1998) 261-292
9. Wakeland E.K., Liu K., Graham R.R., and Behrens T.W. Delineating the genetic basis of systemic lupus erythematosus. Immunity 15 (2001) 397-408
10. Mohan C. Murine lupus genetics: lessons learned. Curr Opin Rheumatol 13 (2001) 352-360
11. Tsao B.P. An update on genetic studies of systemic lupus erythematosus. Curr Rheumatol Rep 4 (2002) 359-367
12. Theofilopoulos A.N., and Kono D.H. The genes of systemic autoimmunity. Proc Assoc Am Physicians 111 (1999) 228-240
13. Rozzo S.J., Allard J.D., Choubey D., Vyse T.J., Izui S., Peltz G., et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity 15 (2001) 435-443
14. Choubey D., and Kotzin B.L. Interferon-inducible p202 in the susceptibility to systemic lupus. Front Biosci 7 (2002) e252-e262
15. Kammer G.M., Perl A., Richardson B.C., Tsokos G.C., and Abnormal. T cell signal transduction in systemic lupus erythematosus. Arthritis Rheum 46 (2002) 1139-1154
16. Takeuchi T., Tsuzaka K., Abe T., Yoshimoto K., Shiraishi K., Kameda H., et al. T- cell abnormalities in systemic lupus erythematosus. Autoimmunity 38 (2005) 339-346
17. Chen Y., and Morel L. Genetics of T cell defects in lupus. Cell Mol Immunol 2 (2005) 403-409
18. Su B., Jacinto E., Hibi M., Kallunki T., Kari M., and Ben-Neriah Y. JNK is involved in signal integration during co-stimulation of T lymphocytes. Cell 77 (1994) 727-736
19. Rincon M., Flavell R.A., and Davis R.J. Signal transduction by MAP kinases in T lymphocytes. Oncogene 20 (2001) 2490-2497
20. Weston C.R., and Davis R.J. The JNK signal transduction pathway. Curr Opin Genet Dev 12 (2002) 14-21
21. Dong C., Yang D.D., Wysk M., Whitmarsh A.J., Davis R.J., and Flavell R.A. Defective T cell differentiation in the absence of Jnk1. Science 282 (1998) 2092-2095
22. Yang D.D., Conze D., Whitmarsh A.J., Barrett T., Davis R.J., Rincon M., et al. Differentiation of CD4 T cells to Th1 cells requires MAP kinase JNK2. Immunity 9 (1998) 575-585
23. Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76 (1994) 1025-1037
24. Wagner E.F., and Eferl R. Fos/AP-1 proteins in bone and the immune system. Immunol Rev 208 (2005) 126-140
25. Katsiari C.G., and Tsokos G.C. Transcriptional repression of interleukin-1 in human systemic lupus erythematosus. Autoimmun Rev 5 (2006) 118-121
26. Sarin A., Adams D.H., and Henkart P.A. Protease inhibitors block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells. J Exp Med 178 (1993) 1693-1700
27. Johnson R., Spiegelman B., Hanahan D., and Wisdom R. Cellular transformation and malignancy induced by ras require c-jun. Mol Cell Biol 16 (1996) 4504-4511
28. Han Z.D., Boyle L., Chang L., Bennett B., Karin M., Young L., et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 108 (2001) 73-81
29. Cano E., Hazzalin C.A., and Mahadevan L.C. Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol Cell Biol 14 (1994) 7352-7362
30. Choubey D., and Lengyel P. Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi200 gene from the gene 200 cluster. J Interferon Res 13 (1993) 43-52
31. Pramanik R., Jorgensen T.N., Xin H., Kotzin B.L., and Choubey D. Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility. J Biol Chem 279 (2004) 16121-16127
32. Choubey D., Snoddy J., Chaturvedi V., Toniato E., Opdenakker G., Thakur A., et al. Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. J Biol Chem 264 (1989) 17182-17189
33. D'Souza S., Xin H., Walte S., and Choubey D. The gene encoding p202, an interferon-inducible negative regulator of the p53 tumor suppressor, is a target of p53-mediated transcriptional repression. J Biol Chem 276 (2001) 298-305
34. Choubey D. p202: an interferon-inducible negative regulator of cell growth. J Biol Regul Homeost Agents 14 (2000) 187-192
35. Memon S.A., Belen Moreno M., Petrak D., and Zacharchuk C.M. Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. J Immunol 155 (1995) 4644-4652
36. Geng Y., D'Souza S., Xin H., Walter S., and Choubey D. p202 levels are negatively regulated by serum growth factors. Cell Growth Differ 11 (2000) 475-483
37. Mechta-Grigoriou F., Gerald D., and Yaniv M. The mammalian Jun proteins: redundancy and specificity. Oncogene 20 (2001) 2378-2389
38. Wither J., and Vukusic B. Autoimmunity develops in lupus-prone NZB mice despite normal T cell tolerance. J Immunol 161 (1998) 4555-4562
39. Xin H., Geng Y., Pramanik R., and Choubey D. Induction of apoptosis, a modulator of apoptosis, during oncogenic transformation of NIH 3T3 cells by activated H-Ras (Q61L) contributes to cell survival. J Cell Biochem 88 (2003) 191-194
40. Wen Y., Yan D.H., Spohn B., Deng J., Lin S.Y., and Hung M.C. Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells. Cancer Res 60 (2000) 42-46
41. Wang H., Liu C., Lu Y., Chatterjee G., Ma X.Y., Eisenman R.N., et al. The interferon- and differentiation-inducible p202a protein inhibits the transcriptional activity of c-Myc by blocking its association with Max. J Biol Chem 275 (2000) 27377-27385
42. Beg A.A., and Baldwin A.S. The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev 7 (1993) 2064-2070
43. Lissy N.A., Davis P.K., Irwin M., Kaelin W.G., and Dowdy S.F. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature 407 (2000) 642-645
44. Xin H., D'Souza, Jorgensen T.N., Vaughan A.T., Lengyel P., Kotzin B.L., et al. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol 176 (2006) 5863-5870
45. Schreiber M., Kolbus A., Piu F., Azabowski A., Mohle-Steinlein U., Tian J., et al. Control of cell cycle progression by c-Jun is p53-dependent. Genes Dev 13 (1999) 607-619
46. Wong H.K., Kammer G.M., Dennis G., and Tsokos G.C. Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression. J Immunol 163 (1999) 1682-1689
47. Gubbels M.R., Jorgensen T.N., Metzger T.E., Menze K., Steele H., Flannery S.A., et al. Effects of MHC and gender on lupus-like autoimmunity in Nba2 congenic mice. J Immunol 175 (2005) 6190-6196
48. Min W., Ghosh S., and Lengyel P. The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities. Mol Cell Biol 16 (1996) 359-368