Tumor suppression and sensitization to tumor necrosis factor α-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells

Cancer Research

Volumn 60, Issue 1, 2000, Pages 42-46

  Wen, Yong ^a   Yan, Duen Hwa ^a   Spohn, Bill ^a   Deng, Jiong ^a   Lin, Shiaw Yih ^a   Hung, Mien Chie ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; INTERFERON INDUCIBLE PROTEIN; PROTEIN P202; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENSITIZATION;

APOPTOSIS; BREAST NEOPLASMS; CARRIER PROTEINS; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASM PROTEINS; NF-KAPPA B; PHENOTYPE; PHOSPHOPROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033958683     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Gutterman, J. U. Cytokine therapeutics: lessons from interferon α. Proc. Natl. Acad. Sci. USA, 91: 1198-1205, 1994.
2. Choubey, D., Snoddy, J., Chaturvedi, V., Toniato, E., Opdenakker, G., Thakur, A., Samanta, H., Engel, D. A., and Lengyel, P. Interferons as gene activators-indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. J. Biol. Chem., 264: 17182-17189, 1989.
3. Choubey, D., Li, S-J., Datta, B., Gutterman, J. U., and Lengyel, P. Inhibition of E2F-mediated transcription by p202. EMBO J., 15: 5668-5678, 1996.
4. Choubey, D., and Gutterman, J. U. Inhibition of E2F-4/DP-1-stimulated transcription by p202. Oncogene, 15: 291-301, 1997.
5. Datta, B., Li, B., Choubey, D., Nallur, G., and Lengyel, P. p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J. Biol. Chem., 271: 27544-27555, 1996.
6. Min, W., Ghosh, S., and Lengyel, P. The interferon-inducible p202 protein as a modulator of transcription: inhibition of NFKB, c-Fos, and c-Jun activities. Mol. Cell. Biol., 16: 359-368, 1996.
7. Datta, B., Min, W., Burma, S., and Lengyel, P. Increase in p202 expression during skeletal muscle differentialion: inhibition of MyoD protein expression and activity by p202. Mol. Cell. Biol., 18: 1074-1083, 1998.
8. Choubey, D., and Lengyel, P. Binding of an interferon-inducible protein (p202) to the retinoblastoma protein. J. Biol. Chem., 270: 6134-6140, 1995.
9. Lembo, D., Angeretti, A., Benefazio, S., Hertel, L., Gariglio, M., Novelli, F., and Landolfo, S. Constitutive expression of the interferon-inducible prolein p202 in N1H3T3 cells affects cell cycle progression. J. Biol. Regul. Homeostatic Agents, 9: 42-46, 1995.
10. Van, D-H., Wen, Y., Spohn, B., Choubey, D., Gutterman, J. U., and Hung, M-C. Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202. Oncogene, 18: 807-811, 1999.
11. Choubey, D., and Lengyel, P. Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi202 gene from the gene 200 cluster. J. Interferon Res., 13: 43-52, 1993.
12. Shao, R., Karunagaran, D., Zhou, B. P., Li, K., Lo, S-S., Deng, J., Chiao, P., and Hung, M-C. Inhibition of nuclear factor-KB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis. J. Biol. Chem., 272: 32739-32742, 1997.
13. Wang, C. Y., Mayo, M. W., and Baldwin, A. S., Jr. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-KB (see comments]. Science (Washington DC), 274: 784-787, 1996.
14. Beg, A. A., and Baltimore, D. An essential role for NF-KB in preventing TNF-α-induced cell death [see comments]. Science (Washington DC), 274: 782-784, 1996.
15. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R., and Verma, I. M. Suppression of TNF-α-induced apoptosis by NF-KB [see comments]. Science (Washington DC), 274: 787-789, 1996.
16. Sugarman, B. J., Aggarwal, B. B., Hass, P. E., Figari, I. S., Palladino, M. A., Jr., and Shepard, H. M. Recombinant human tumor necrosis factor-α: effects on proliferation of normal and transformed cells in vitro. Science (Washington DC), 230: 943-945, 1985.
17. Frei, E. D., and Spriggs, D. Tumor necrosis factor: still a promising agent. J. Clin. Oncol., 7: 291-294, 1989.