Autoimmunity develops in lupus-prone NZB mice despite normal T cell tolerance

Journal of Immunology

Volumn 161, Issue 9, 1998, Pages 4555-4562

  Wither, Joan ^a,b   Vukusic, Brian ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BOVINE INSULIN; CYTOKINE; DNA ANTIBODY; ERYTHROCYTE ANTIBODY; FREUND ADJUVANT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIBODY; SINGLE STRANDED DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CLONAL ANERGY; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ANIMALS; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CATTLE; CLONAL ANERGY; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; FEMALE; IMMUNITY, CELLULAR; IMMUNOGLOBULIN M; INSULIN; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; LYMPHOKINES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED NZB; MICE, TRANSGENIC; T-LYMPHOCYTE SUBSETS; TRANSGENES;

EID: 0032212247     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Theofilopoulos, A. N. 1992. Murine models of lupus. In Systemic Lupus Erythematosus, 2nd Ed. R. G. Lahita, ed. Churchill Livingstone, New York, p. 121.
2. bm12 mice. J. Immunol. 145:94.
3. 1 mice. Immunol. Rev. 144:51.
4. Diamond, B., J. B. Katz, E. Paul, C. Aranow, and M. D. Scharff. 1992. The role of somatic mutation in the pathogenic anti-DNA response. Annu. Rev. Immunol. 10:731.
5. 1 mice: thymus-independent occurrence of B cell abnormality and requirement for T cells in the development of autoimmune disease, as evidenced by an analysis of the athymic nude individuals. J. Immunol. 141/85.
6. 1 mice with monoclonal antibody to L3T4. J. Exp. Med. 161/378.
7. + T cells is required to suppress autoimmunity. J. Immunol. 149:3083.
8. 1 mouse model of systemic lupus erythematosus. Arthritis Rheum. 36:355.
9. Mohan, C., S. Adams, V. Stanik, and S. K. Datta. 1993. Nucleosome: a major immunogen for pathogenic autoantibody inducing T cells of lupus. J. Exp. Med. 177:1367.
10. Rozzo, S. J., C. G. Drake, B. Chiang, M. E. Gershwin, and B. Kotzin. 1994. Evidence for polyclonal T cell activation in murine models of systemic lupus erythematosus. J. Immunol. 153:1340.
11. Kappler, J., N. Roehm, and P. Marrack. 1987. T-cell tolerance by clonal elimination in the thymus. Cell 49:273.
12. Sha, W. C., C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336:73.
13. + thymocytes. Nature 333:742.
14. Jones, L. A., L. T. Chin, D. L. Longo, and A. M. Kruisbeek. 1990. Peripheral clonal elimination of functional T cells. Science 250:1726.
15. Miller, J. F. A. P., and G. Morahan. 1991. Peripheral T cell tolerance. Annu. Rev. Immunol. 10:51.
16. Bloom, B. R., R. L. Modlin, and P. Salgane. 1992. Stigma variations: observations on T cells and leprosy. Annu. Rev. Immunol. 10:453.
17. Ohashi, P. S., S. Oehen, K. Buerkin, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malisson, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
18. Kotzin, B. L., J. Kappler, P. C. Marrack, and L. R. Herron. 1989. T cell tolerance to self antigens in New Zealand hybrid mice with lupus-like disease. J. Immunol. 143:89.
19. Theofilopoulos, A. N., P. A. Singer, R. Kofler, D. H. Kono, M. A. Duchosal, and R. S. Balderas. 1989. B and T cell antigen receptor repertoires in lupus/arthritis murine models. Springer Semin. Immunopathol. 11/335.
20. Scott., D. E., W. J. Kisch, and A. D. Steinberg. 1993. Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal lupus-prone mice. J. Immunol. 150:664.
21. Staples, P. J., A. D. Steinberg, and N. Talal. 1970. Induction of immunologic tolerance in older New Zealand mice repopulated with young spleen, bone marrow, and thymus. J. Exp. Med. 131/1223.
22. Laskin, C. A., J. D. Taurog, P. A. Smathers, and A. D. Steinberg. 1981. Studies of defective tolerance in murine lupus. J. Immunol. 127:1743.
23. Eynon, E. E., and D. C. Parker. 1992. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 175:131.
24. Burstein, H. J., C. M. Shea, and A. K. Abbas. 1992. Aqueous antigens induce in vivo tolerance selectively in IL-2 and IFN-γ-producing (Th1) cells. J. Immunol. 148:3687.
25. De Wit, D., M. Van Mechelen, M. Ryelandt, A. C. Figueiredo, D. Abramowicz, M. Goldman, H. Bazin, J. Urbain, and O. Leo. 1992. The injection of deaggregated γ-globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes. J. Exp. Med. 175:9.
26. + cell subsets. J. Exp. Med. 178:1637.
27. Poplonski, L., B. Vukusic, J. Pawling, S. Clapoff, J. Roder, N. Hozumi, and J. Wither. 1996. Tolerance is overcome in bovine insulin-transgenic mice by activation of low-affinity autoreactive T cells. Eur. J. Immunol. 26: 601.
28. Teng, Y.-T., R. M. Gorczynski, S. Iwasaki, D. B. Williams, and N. Hozumi. 1995. Evidence for Th2 cell-mediated suppression of antibody responses in transgenic, bovine insulin-tolerant mice. Eur. J. Immunol. 25:2522.
29. Perry, F. E., R. N. Barker, G. Mazza, M. J. Day, A. D. Wells, C. R. Shen, A. E. Schofield, and C. J. Elson. 1996. Autoreactive T cell specificity in autoimmune hemolytic anemia of the NZB mouse. Eur. J. Immunol. 26:136.
30. 2-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485.
31. Hsieh, C.-S., S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1995. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181/713.
32. Scott, B., R. Liblau, S. Degermann, L. A. Marconi, L. Ogata, A. J. Caton, H. O. McDevitt, and D. Lo. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1/73.
33. Adelstein, S., H. Pritchard-Briscoe, T. A. Andersen, J. Crosbie, G. Gammon, R. H. Loblay, A. Basten, and C. Goodnow. 1991. Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science 251/1223.
34. Whitely, P. J., N. J. Poindexter, C. Landon, and J. A. Kapp. 1990. A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice. J. Immunol. 145:1376.
35. Dauphinee, M. J., S. B. Kipper, D. Wofsy, and N. Talal. 1981. Interleukin 2 deficiency is a common feature of autoimmune mice. J. Immunol. 127:2483.
36. Ding, L., P. S. Linsley, L.-Y. Huang, R. N. Germain, and E. M. Shevach. 1993. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J. Immunol. 151/1224.
37. Fiorentino D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147: 3815.
38. Fiorentino, D. F., A. Zlotnik, P. Viera, T. R. Mosmann, M. Howard, K. W. Moore, and A. O'Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:3444.
39. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
40. O'Garra, A., R. Chang, N. Go, R. Hastings, G. Haughton, and M. Howard. 1992. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur. J. Immunol. 22:711.
41. Park, C. L., R. S. Balderas, T. M. Fieser, J. H. Slack, G. J. Prud'homme, F. J. Dixon, and A. N. Theofilopoulos. 1983. Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes. J. Immunol. 130:2161.
42. 1 mice show altered IgG isotype switching upon T cell-dependent antigenic stimulation. Clin. Immunol. Immunopathol. 58:33.
43. 1 mice are hyper-responsive to T cell-derived stimuli. J. Immunol. 159:5810.
44. 1 mice. Clin. Exp. Immunol 40:373.
45. 1 lupus-like nephritis with monoclonal antibodies to γ-interferon. J. Exp. Med 166:798.
46. Ozmen., L., D. Roman, M. Fountoulakis, G. Schmid, B. Ryffel, and G. Garotta. 1995. Experimental therapy of systemic lupus erythematosus: the treatment of NZBAV mice with mouse soluble interferon-γ receptor inhibits the onset of glomerulonephritis. Eur. J. Immunol. 25:6.
47. 1 mice. J. Immunol 158:1466.
48. 1 mice. J. Exp. Med. 179:305.
49. Shen, C. R., G. Mazza, F. E. Perry, J. T. Beech, S. J. Thompson, A. Corato, S. Newton, R. N. Barker, and C. J. Elson. 1996. T-helper 1 dominated responses to erythrocyte band 3 in NZB mice. Immunology 89:195.
50. 1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc. Natl. Acad. Sci. USA 93:8563.