Impaired neuroglial activation in interleukin-6 deficient mice

GLIA

Volumn 19, Issue 3, 1997, Pages 227-233

  Klein, Michael A ^a   Möller, J Carsten ^a   Jones, Leonard L ^a   Bluethmann, Horst ^b   Kreutzberg, Georg W ^a   Raivich, Genadij ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

astrocytes; cytokines; knockout; microglia; regeneration

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; INTEGRIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN RECEPTOR; LEUKOCYTE ANTIGEN;

ANIMAL; ARTICLE; C57BL MOUSE; CYTOLOGY; FACIAL NERVE; FACIAL NERVE INJURY; GLIA; IMMUNOLOGY; MOUSE;

ANIMALS; ANTIGENS, CD; FACIAL NERVE; FACIAL NERVE INJURIES; GLIAL FIBRILLARY ACIDIC PROTEIN; INTEGRINS; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; NEUROGLIA; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-6;

EID: 0031104861     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199703)19:3<227::AID-GLIA5>3.0.CO;2-W     Document Type: Article

References (48)

1. Aderka, D., Le, J., and Vilcek, J. (1989) IL6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells and in mice. J. Immunol., 143:3517-3523.
2. Aloisi, F., Care, A., Borselino, G., Gallo, P., Rosa, S., Bassani, A., Cabibo, A., Testa, U., Levi, G., and Peschle, C. (1992) Production of hemalymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1β and tumor necrosis factor. J. Immunol., 149:2358-2366.
3. Balasingham, V., Tejada-Berges, T., Wright, E., Bouckova, R., Yong, W. (1994) Reactive astrogliosis in neonatal mouse brain and its modulation by cytokines. J. Neurosci., 14:846-856.
4. Bazan, J.F. (1991) Neuropoietic cytokines in the hematopoietic fold. Neuron, 7:197-208.
5. Blinzinger, K. and Kreutzberg, G.W. (1968) Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z. Zellforsch., 85:145-157.
6. Campbell, L., Abraham, C.R., Masliah, E., Kembper, P., Inglis, J.D., Oldstone, M.B., and Mucke, L. (1993) Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA, 90:10061-10065.
7. Curtis, R., Scherer, S.S., Somogyi, R., Adryan, K.M., Ip, N.Y., Zhu, Y., Lindsay, R.M., and DiStephano, P.S. (1994) Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve. Neuron 12:191-204.
8. Eddleston, M. and Mucke, L. (1993) Molecular profile of reactive astrocytes. Neurosci., 54, 15-36.
9. Fabry, Z., Fitzsimmons, K.M., Herlein, J.A., Moninger, T.O., Dobbs, M.B., and Hart, M.N. (1993) Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes. J. Neuroimmunol., 47:23-34.
10. Fattori, E., Lazzaro, D., Musiani, P., Modesti, A., Alonzi, T., and Cilberto, G. (1995) IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage. Eur. J. Neurosci., 7:2441-2449.
11. Frei, K., Malipiero, U.V., Leist, T.P., Zinkernagel, R.M., Schwab, M.E., and Fontana, A. (1989) On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. Eur. J. Neurosci., 19:689-694.
12. Gauldie, J., Richards, C., Harnish, D., Lansdorp, P., and Baumann, H. (1987) Interferon-β2/B cell-stimulatory factor type 2 shares identity with monocyte-derived hepatocyte stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. USA, 84:7251-7255.
13. Gluckman, P.D., Klempt, N.D., Guan, J., Mallard, E.C., Sirimanne, E., Dragunow, M., Klempt, M., Singh, K., Williams, C., and Nicolics, K. (1992) A role for IGF-I in the rescue of CNS neurons following hypoxic-ischemic injury. Biochem. Biophys. Res. Commun., 182:593-599.
14. Graeber, M.B. and Kreutzberg, G.W. (1986) Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons. J. Neurocytol., 15:363-373.
15. Graeber, M.B. and Kreutzberg, G.W. (1988) Delayed astrocyte reaction following facial nerve axotomy. J. Neurocytol., 17:209-220.
16. Graeber, M.B., Tetzlaff, W., Streit, W.J., and Kreutzberg, G.W. (1988) Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy. Neurosci. Lett., 85:317-321.
17. Hama, T., Kushima, Y., Miyamoto, M., Kubota, M., Taga, T., and Kishimoto. T. (1991) Interleukin-6 improves the survival of mesencephaclic catecholaminergic and septal cholinergic neurons from postnatal two-week-old rats in culture. Neurosci., 40:445-452.
18. Hermanson, M., Olsson, T., Westermark, B., and Funa, K. (1995) PDGF and its receptors following facial nerve axotomy in rats: expression in neurons and surrounding glia. Exp. Brain Res., 102:415-422.
19. Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y, Matsuda, T., Kashiwamura, S., Nakajima, K., Koyama, K., Iwamatsu, A., Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y., Taniguchi, T., and Kishimito, T. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature, 324:73-76.
20. Hopkins, S.J. and Rothwell, N.J. (1995) Cytokines and the nervous system: expression and recognition. Trends Neurosci., 18:83-88.
21. Ikebuchi K., Wong, G.G., Clark, S.C., Ihle, J.N., Yoshikatsu, H., and Ogawa, M. (1987) Interleukin-6 enhancement of interleukin-3 dependent proliferation of multipotential hematopoietic progenitors. Proc. Natl. Acad. Sci. USA, 84:9035-9039.
22. Ip, N.Y., McClain, J., Barrezueta, N.X., Aldrich, T.H., Pan, L., Wiegand, S.J., Friedman, B., Dacis, S., and Yancopoulos, G.D. (1993) The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron, 10:89-102.
23. Kiefer, R., Lindholm, D., and Kreutzberg, G.W. (1993) Interleukin-6 and transforming growth factor-β1 mRNAs are induced in rat facial nucleus following motoneuron axotomy. Eur. J. Neurosci., 5:775-781.
24. Kishimoto, T., Akira, S., and Taga, T. (1992) Interleukin-6 and its receptor: A paradigm for cytokines. Science, 258:593-597.
25. Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., and Koehler, G. (1994) Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature, 368:339-342.
26. Kreutzberg, G.W. (1995) Reaction of the neuronal cell body to axonal damage. In The Axon, S.G. Waxman, J.D. Kocsis, P.K. Stys, eds. Oxford University Press, pp. 355-374.
27. Kushima, Y. and Hatanaka, H. (1992) Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord. Neurosci. Lett., 143:110-114.
28. Liu, X., Yao, D.L., Bondy, C., Brenner, M., Hudson, L., Zhou, J., and Webster, H.deF. (1994) Astrocytes express insulin-like growth factor-I (IGF-I) and its binding protein, IGFBP-2, during demyelination induced by experimental autoimmune encephalomyelitis. Mol. Cell Neurosci., 5:418-430.
29. Lotz, M., Jirik, F., Kabouridis, P., Tsoukas, C., Hirano, T., Kishimoto, T., and Carson, D.A. (1988) B cell stimulating factor/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J. Exp. Med., 167:1253-1258.
30. Malipiero, U.V., Frei, K., and Fontana, A. (1990) Production of hematopoietic colony stimulating factors by astrocytes. J. Immunol., 144:3816-3821.
31. Möller, J.C., Klein, M.A., Haas, S., Jones, L.L., Kreutzberg, G.W., and Raivich, G. (1996) Regulation of thrombospondin in the regenerating mouse facial nucleus. Glia, 17:121-132.
32. Moore, R. (1989) Cranial motoneurons contain either galanin- or calcitonin gene-related peptide-like immunoreactivity. J. Comp. Neurol., 282:512-522.
33. Morganti-Kossmann, M.C., Kossmann, T., and Wahl, S.M. (1992) Cytokines and neuropathology. Trends Pharmacol. Sci., 13:286-291.
34. Murphy, P.G., Grondin, J., Altares, M., and Richardson, P.M. (1995) Induction of interleukin-6 in axotomized sensory neurons. J. Neurosci., 15:5130-5138.
35. Norenberg, M.D. (1994) Astrocyte response to CNS injury. J. Neuropathol. Exp. Neurol., 53:213-220.
36. Otsuka, M., Terada, Y., Yang, T., Nonoguchi, H., Tomita, K., and Marumo, F. (1994) Localization of cyclophilin A and cyclophilin C mRNA in murine kidney using RT-PCR. Kidney Int., 45:1340-1345.
37. Patterson, P.H., and Nawa, H. (1993) Neuronal differentiation factors, cytokines, and synaptic plasticity. Neuron, 10:123-137.
38. Pennica, D., King, K.L., Shaw, K.J., Luis, E., Rullamas, J., Luoh, S., Darbonmne, W.C., Knutzon, D.S., Yen, R., Chien, K.R., Baker, J.B., and Wood, W.I. (1995) Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc. Natl. Acad. Sci. USA, 92:1142-1146.
39. Perry, V.H., Hume, D.A., and Gordon, S. (1985) Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neurosci., 15:313-326.
40. I25I]-iodinated secondary antibodies and in situ autoradiography: nonlinear binding characteristics of primary monoclonal and polyclonal antibodies. J. Histochem. Cytochem., 41:579-592.
41. Raivich, G., Moreno-Flores, M.T. Möller, J.C., and Kreutzberg, G.W. (1994) Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse. Eur. J. Neurosci., 6:1615-1618.
42. Raivich, G., Reddington, M., Haas, C.A., and Kreutzberg, G.W. (1995) Peptides in motoneurons. Prog. Brain Res., 104:3-20.
43. Schöbitz, B., de Kloet E.R., Sutanto, W., and Holsboer, F. (1993) Cellular localization of interleukin-6 mRNA and interleukin-6 receptor mRNA in rat brain. Eur. J. Neurosci., 5:1426-1435.
44. Sendtner, M. Stockli, K.A., and Thoenen, H. (1992) Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration. J. Cell Biol., 118:139-148.
45. Shabo, Y, Lotem, J., Rubinstein, M., Revel, M., Clark, S.C., Wolf, S.F., Kamen, R., and Sachs, L. (1988) The myeloid blood cell-differentiation inducing protein MGI-2A is interleukin-6. Blood, 72:2070-2073.
46. Shibuki, K., Gomi, H., Chen, L., Bao, S., Kim, J., Wakatsuki, H., Fujisaki, T., Fujimoto, T., Katoh, A., Ikeda, T., Chen, C., Thompson, R.F., and Itohara, S. (1996) Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice. Neuron, 16:587-599.
47. Stahl, N. and Yancopoulos, G. (1993) The alphas, betas, and kinases of cytokine receptor complexes. Cell, 74:587-590.
48. Toulmond, S., Vige, X., Fage, D., and Benavides, J. (1992) Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons. Neurosci. Lett., 144:49-52.