Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations

Steroids

Volumn 73, Issue 7, 2008, Pages 708-719

  Pedretti, Alessandro ^a   Bocci, Elisabetta ^a   Maggi, Roberto ^b   Vistoli, Giulio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Centre of Excellence on Neurodegenerative Diseases   (Italy)

Author keywords

Cholesterol biosynthesis; DHCR24; Enzymatic product egress; Homology modelling; MD simulation; Seladin 1

Indexed keywords

3 BETA HYDROXYSTEROL REDUCTASE; CHOLESTEROL; CYTOKININ; DESMOSTEROL; ENZYME; OXIDOREDUCTASE; SELADIN 1;

ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; CATALYSIS; CHOLESTEROL SYNTHESIS; DRUG BINDING; DRUG STRUCTURE; DYNAMICS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEGRADATION; HUMAN; MEMBRANE MODEL; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; SIMULATION; STRUCTURAL HOMOLOGY;

CATALYTIC DOMAIN; CHOLESTEROL; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DESMOSTEROL; HUMANS; LIGANDS; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTEIN CONFORMATION;

EID: 43649109013     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2008.02.007     Document Type: Article

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