A network analysis of the human T-cell activation gene network identifies Jagged1 as a therapeutic target for autoimmune diseases

PLoS ONE

Volumn 2, Issue 11, 2007, Pages

  Palacios, Ricardo ^a   Goni, Joaquin ^a,b   Martinez Forero, Ivan ^a,b   Iranzo, Jaime ^a   Sepulcre, Jorge ^a   Melero, Ignacio ^c   Villoslada, Pablo ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; JAGGED1; JAGGED1 AGONIST; PEPTIDE DERIVATIVE; CALCIUM BINDING PROTEIN; MEMBRANE PROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ADULT; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENE INTERACTION; GENE TARGETING; GENETIC DATABASE; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN TARGETING; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; ANIMAL; BAYES THEOREM; C57BL MOUSE; CASE CONTROL STUDY; DRUG ANTAGONISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; METHODOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

MUS;

ANIMALS; BAYES THEOREM; CALCIUM-BINDING PROTEINS; CASE-CONTROL STUDIES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOTHERAPY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 43549125744     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001222     Document Type: Article

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