Origin, regulation and physiological function of intestinal oeosinophils

Best Practice and Research: Clinical Gastroenterology

Volumn 22, Issue 3, 2008, Pages 411-423

  Fulkerson, Patricia C ^a   Rothenberg, Marc E ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

gastrointestinal; oeosinophils

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CD30 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CHEMOKINE; DEATH RECEPTOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EOTAXIN; FAS ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTAMINE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 3; INTERLEUKIN 3; INTERLEUKIN 5; INTERLEUKIN 8; L SELECTIN; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; NERVE GROWTH FACTOR; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; SIALYL LEWIS X ANTIGEN; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR PU 1; TUMOR NECROSIS FACTOR ALPHA;

ALLERGY; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL INTERACTION; CELL LINEAGE; CELL MATURATION; CELL MIGRATION; CELL SURVIVAL; CELL TRANSPORT; CYTOKINE PRODUCTION; CYTOLOGY; DISEASE ASSOCIATION; EFFECTOR CELL; ENTERITIS; EOSINOPHIL; GRANULOCYTE; HELMINTHIASIS; HEMATOPOIETIC CELL; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; LEUKOCYTE FUNCTION; MAST CELL; MOLECULAR MECHANICS; ORGANOGENESIS; PLEIOTROPY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN SECRETION; T LYMPHOCYTE;

CELL MOVEMENT; CYTOKINES; EOSINOPHILS; HUMANS; IMMUNITY, MUCOSAL; INTESTINES;

EID: 43549122615     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpg.2007.10.023     Document Type: Article

References (100)

1. D.G. Tenen R. Hromas J.D. Licht Transcription factors, normal myeloid development, and leukemia Blood 90 1997 489 519
2. K. McNagny T. Graf Making eosinophils through subtle shifts in transcription factor expression J Exp Med 195 2002 F43 F47
3. R.P. DeKoter H. Singh Regulation of B lymphocyte and macrophage development by graded expression of PU.1 Science 288 2000 1439 1441
4. J. Du M.J. Stankiewicz Y. Liu Novel combinatorial interactions of GATA-1, PU.1, and C/EBP epsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein J Biol Chem 277 2002 43481 43494
5. R. Hirasawa R. Shimizu S. Takahashi Essential and instructive roles of GATA factors in eosinophil development J Exp Med 195 2002 1379 1386
6. C. Yu A.B. Cantor H. Yang Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo J Exp Med 195 2002 1387 1395
7. M.E. Rothenberg S.P. Hogan The eosinophil Annu Rev Immunol 2005
8. A.F. Lopez C.J. Sanderson J.R. Gamble Recombinant human interleukin 5 is a selective activator of human eosinophil function J Exp Med 167 1988 219 224
9. Y. Sonoda N. Arai M. Ogawa Humoral regulation of eosinophilopoiesis in vitro: analysis of the targets of interleukin-3, granulocyte/macrophage colony-stimulating factor (GM-CSF), and interleukin-5 Leukemia 3 1989 14 18
10. E.J. Clutterbuck E.M. Hirst C.J. Sanderson Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF Blood 73 1989 1504 1512
11. M. Vadas A. Lopez J. Gamble Cytokines and allergy J Allergy Clin Immunol 94 1994 1289 1293
12. C.J. Sanderson Interleukin-5, eosinophils, and disease Blood 79 1992 3101 3109
13. P.D. Collins S. Marleau D.A. Griffiths-Johnson Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo J Exp Med 182 1995 1169 1174
14. D. Simon H.U. Simon Eosinophilic disorders J Allergy Clin Immunol 2007
15. W.F. Owen M.E. Rothenberg J. Petersen Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome J Exp Med 170 1989 343 348
16. E.M. Vassina S. Yousefi D. Simon cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis Eur J Immunol 36 2006 1975 1984
17. M.J. Leckie A. ten Brinke J. Khan Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response Lancet 356 2000 2144 2148
18. J.C. Kips B.J. O'Connor S.J. Langley Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study Am J Respir Crit Care Med 167 2003 1655 1659
19. P. Flood-Page A. Menzies-Gow S. Phipps Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics J Clin Invest 112 2003 1029 1036
20. J.K. Garrett S.C. Jameson B. Thomson Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes J Allergy Clin Immunol 113 2004 115 119
21. P. Gevaert D. Lang-Loidolt A. Lackner Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps J Allergy Clin Immunol 118 2006 1133 1141
22. M.L. Stein M.H. Collins J.M. Villanueva Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis J Allergy Clin Immunol 118 2006 1312 1319
23. K. Ebnet E.P. Kaldjian A.O. Anderson Orchestrated information transfer underlying leukocyte endothelial interactions Annu Rev Immunol 14 1996 155 177
24. M.B. Resnick P.F. Weller Mechanisms of eosinophil recruitment Am J Respir Cell Mol Biol 8 1993 349 355
25. A. Wardlaw Eosinophil trafficking: new answers to old questions Clin Exp Allergy 34 2004 676 679
26. A.J. Wardlaw The role of adhesion in eosinophil function Chem Immunol 78 2000 93 111
27. P. Sriramarao U.H. von Andrian E.C. Butcher L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo J Immunol 153 1994 4238 4246
28. S.N. Georas M.C. Liu W. Newman Altered adhesion molecule expression and endothelial cell activation accompany the recruitment of human granulocytes to the lung after segmental antigen challenge Am J Respir Cell Mol Biol 7 1992 261 269
29. E.L. Berg L.M. McEvoy C. Berlin L-selectin-mediated lymphocyte rolling on MAdCAM-1 Nature 366 1993 695 698
30. F.A. Symon M.B. Lawrence M.L. Williamson Functional and structural characterization of the eosinophil P-selectin ligand J Immunol 157 1996 1711 1719
31. A.J. Wardlaw G.M. Walsh F.A. Symon Adhesion interactions involved in eosinophil migration through vascular endothelium Ann N Y Acad Sci 796 1996 124 137
32. H. Tachimoto B.S. Bochner The surface phenotype of human eosinophils Chem Immunol 76 2000 45 62
33. H. Tachimoto M. Ebisawa B.S. Bochner Cross-talk between integrins and chemokines that influences eosinophil adhesion and migration Int Arch Allergy Immunol 128 Suppl. 1 2002 18 20
34. D. Broide P. Sriramarao Eosinophil trafficking to sites of allergic inflammation Immunol Rev 179 2001 163 172
35. S.K. Shaw M.B. Brenner The beta 7 integrins in mucosal homing and retention Semin Immunol 7 1995 335 342
36. E.C. Butcher M. Williams K. Youngman Lymphocyte trafficking and regional immunity Adv Immunol 72 1999 209 253
37. D. Artis N.E. Humphreys C.S. Potten Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection Eur J Immunol 30 2000 1656 1664
38. A. Mishra S.P. Hogan E.B. Brandt Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking J Biol Chem 277 2002 4406 4412
39. E. Forbes M. Hulett R. Ahrens ICAM-1-dependent pathways regulate colonic eosinophilic inflammation J Leukoc Biol 80 2006 330 341
40. W.J. Sandborn S.R. Targan Biologic therapy of inflammatory bowel disease Gastroenterology 122 2002 1592 1608
41. S. Ghosh E. Goldin F.H. Gordon Natalizumab for active Crohn's disease N Engl J Med 348 2003 24 32
42. H. Floyd J. Ni A.L. Cornish Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily J Biol Chem 275 2000 861 866
43. K.K. Kikly B.S. Bochner S.D. Freeman Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils J Allergy Clin Immunol 105 2000 1093 1100
44. M.E. Rothenberg CD44 – a sticky target for asthma J Clin Invest 111 2003 1460 1462
45. A. Munitz F. Levi-Schaffer Inhibitory receptors on eosinophils: a direct hit to a possible Achilles heel? J Allergy Clin Immunol 2007
46. M. Kato G.M. Kephart N.J. Talley Eosinophil infiltration and degranulation in normal human tissue Anat Rec 252 1998 418 425
47. A. Mishra S.P. Hogan J.J. Lee Fundamental signals that regulate eosinophil homing to the gastrointestinal tract J Clin Invest 103 1999 1719 1727
48. A. Lowichik A.G. Weinberg A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract Mod Pathol 9 1996 110 114
49. C.W. DeBrosse J.W. Case P.E. Putnam Quantity and distribution of eosinophils in the gastrointestinal tract of children Pediatr Dev Pathol 9 2006 210 218
50. R.R. Pascal T.L. Gramlich K.M. Parker Geographic variations in eosinophil concentration in normal colonic mucosa Mod Pathol 10 1997 363 365
51. M.E. Rothenberg Eosinophilic gastrointestinal disorders (EGID) J Allergy Clin Immunol 113 2004 11 28
52. P.J. Jose D.A. Griffiths-Johnson P.D. Collins Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation J Exp Med 179 1994 881 887
53. A.N. Matthews D.S. Friend N. Zimmermann Eotaxin is required for the baseline level of tissue eosinophils Proc Natl Acad Sci U S A 95 1998 6273 6278
54. S.P. Hogan A. Mishra E.B. Brandt A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation Nat Immunol 2 2001 353 360
55. P.S. Foster S.P. Hogan A.J. Ramsay Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model J Exp Med 183 1996 195 201
56. U. Forssmann M. Uguccioni P. Loetscher Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes J Exp Med 185 1997 2171 2176
57. A. Shinkai H. Yoshisue M. Koike A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils J Immunol 163 1999 1602 1610
58. M. Kitaura N. Suzuki T. Imai Molecular cloning of a novel human CC chemokine (eotaxin-3) that is a functional ligand of CC chemokine receptor 3 J Biol Chem 274 1999 27975 27980
59. S.M. Pope P.C. Fulkerson C. Blanchard Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation J Biol Chem 280 2005 13952 13961
60. N. Zimmermann S.P. Hogan A. Mishra Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression J Immunol 165 2000 5839 5846
61. E.A. Garcia-Zepeda M.E. Rothenberg R.T. Ownbey Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia Nat Med 2 1996 449 456
62. P.D. Ponath S. Qin T.W. Post Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils J Exp Med 183 1996 2437 2448
63. B.L. Daugherty S.J. Siciliano J.A. DeMartino Cloning, expression, and characterization of the human eosinophil eotaxin receptor J Exp Med 183 1996 2349 2354
64. M.F. Gurish A. Humbles H. Tao CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis J Immunol 168 2002 5730 5736
65. C. Blanchard N. Wang K.F. Stringer Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis J Clin Invest 116 2006 536 547
66. I. Sabroe M.J. Peck B.J. Van Keulen A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry J Biol Chem 275 2000 25985 25992
67. S. Main R. Handy J. Wilton A potent human anti-eotaxin1 antibody, CAT-213: isolation by phage display and in vitro and in vivo efficacy J Pharmacol Exp Ther 319 2006 1395 1404
68. G.V. De Lucca Recent developments in CCR3 antagonists Curr Opin Drug Discov Devel 9 2006 516 524
69. T. Morokata K. Suzuki Y. Masunaga A novel, selective, and orally available antagonist for CC chemokine receptor 3 J Pharmacol Exp Ther 317 2006 244 250
70. A.E. Butterworth The eosinophil and its role in immunity to helminth infection Curr Top Microbiol Immunol 77 1977 127 168
71. A.E. Butterworth Cell-mediated damage to helminths Adv Parasitol 23 1984 143 235
72. C.A. Behm K.S. Ovington The role of eosinophils in parasitic helminth infections: insights from genetically modified mice Parasitol Today 16 2000 202 209
73. E.A. Jacobsen A.G. Taranova N.A. Lee Eosinophils: singularly destructive effector cells or purveyors of immunoregulation? J Allergy Clin Immunol 2007
74. V. Gouon-Evans M.E. Rothenberg J.W. Pollard Postnatal mammary gland development requires macrophages and eosinophils Development 127 2000 2269 2282
75. J. Zhang L.J. Lathbury L.A. Salamonsen Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium Biol Reprod 62 2000 404 411
76. G.J. Gleich E. Frigas D.A. Loegering Cytotoxic properties of the eosinophil major basic protein J Immunol 123 1979 2925 2927
77. N.R. Slifman D.A. Loegering D.J. McKean Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein J Immunol 137 1986 2913 2917
78. H.F. Rosenberg J.B. Domachowske Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens J Leukoc Biol 70 2001 691 698
79. H. Nagase S. Okugawa Y. Ota Expression and function of toll-like receptors in eosinophils: activation by toll-like receptor 7 ligand J Immunol 171 2003 3977 3982
80. S. Phipps C.E. Lam S. Mahalingam Eosinophils contribute to innate anti-viral immunity and promote clearance of respiratory syncytial virus Blood 2007
81. H. Kita The eosinophil: a cytokine-producing cell? J Allergy Clin Immunol 97 1996 889 892
82. M. Gharaee-Kermani S.H. Phan The role of eosinophils in pulmonary fibrosis (review) Int J Mol Med 1 1998 43 53
83. S. Phipps S. Ying A. Wangoo The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin J Immunol 169 2002 4604 4612
84. K. Matsumoto R.P. Schleimer H. Saito Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro Blood 86 1995 1437 1443
85. S. Tsuyuki C. Bertrand F. Erard Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways J Clin Invest 96 1995 2924 2931
86. D.R. Green C.F. Ware Fas-ligand: privilege and peril Proc Natl Acad Sci U S A 94 1997 5986 5990
87. E. Nutku H. Aizawa S.A. Hudson Ligation of siglec-8: a selective mechanism for induction of human eosinophil apoptosis Blood 101 2003 5014 5020
88. J.M. Kessel J.B. Sedgwick W.W. Busse Ligation of intercellular adhesion molecule 3 induces apoptosis of human blood eosinophils and neutrophils J Allergy Clin Immunol 118 2006 831 836
89. M.G. Blaylock D.W. Sexton G.M. Walsh Ligation of CD45 and the isoforms CD45RA and CD45RB accelerates the rate of constitutive apoptosis in human eosinophils J Allergy Clin Immunol 104 1999 1244 1250
90. K. Matsumoto M. Terakawa K. Miura Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro J Immunol 172 2004 2186 2193
91. P.V. Del A.B. De E. Martin Eosinophil as antigen-presenting cell: activation of T cell clones and T cell hybridoma by eosinophils after antigen processing Eur J Immunol 22 1992 1919 1925
92. D.R. Lucey A. Nicholson-Weller P.F. Weller Mature human eosinophils have the capacity to express HLA-DR Proc Natl Acad Sci U S A 86 1989 1348 1351
93. N. Tamura N. Ishii M. Nakazawa Requirement of CD80 and CD86 molecules for antigen presentation by eosinophils Scand J Immunol 44 1996 229 238
94. J.P. Justice M.T. Borchers J.J. Lee Ragweed-induced expression of GATA-3, IL-4, and IL-5 by eosinophils in the lungs of allergic C57BL/6 J mice Am J Physiol Lung Cell Mol Physiol 282 2002 L302 L309
95. A. Gessner K. Mohrs M. Mohrs Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production J Immunol 174 2005 1063 1072
96. J.R. MacKenzie J. Mattes L.A. Dent Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte function J Immunol 167 2001 3146 3155
97. M. Throsby A. Herbelin J.M. Pleau CD11c+ eosinophils in the murine thymus: developmental regulation and recruitment upon MHC class I-restricted thymocyte deletion J Immunol 165 2000 1965 1975
98. A.M. Piliponsky G.J. Gleich I. Bar Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation Mol Immunol 38 2002 1369 1372
99. A. Solomon L. Aloe J. Pe'er Nerve growth factor is preformed in and activates human peripheral blood eosinophils J Allergy Clin Immunol 102 1998 454 460
100. E.D. Bullock E.M. Johnson Jr. Nerve growth factor induces the expression of certain cytokine genes and bcl-2 in mast cells. Potential role in survival promotion J Biol Chem 271 1996 27500 27508