Neuroendocrine hormonal conditions in epilepsy: Relationship to reproductive and sexual functions

Neurologist

Volumn 14, Issue 3, 2008, Pages 157-169

  Hamed, Sherifa Ahmed ^a  

^a ASSIUT UNIVERSITY   (Egypt)

Author keywords

Antiepileptic drugs; Epilepsy; Hormones; Reproduction; Sexual dysfunction

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 5ALPHA DEOXYCORTICOSTERONE; ACETAZOLAMIDE; ALLOTETRAHYDRODEOXYCORTICOSTERONE; CARBAMAZEPINE; CONJUGATED ESTROGEN; CORTISONE; DEOXYCORTICOSTERONE; ESTRADIOL; ESTROGEN; FOLLITROPIN; GABAPENTIN; GANAXOLONE; GESTAGEN; GONADORELIN; HYDROCORTISONE; LAMOTRIGINE; LOSIGAMONE; LUTEINIZING HORMONE; MEDROXYPROGESTERONE ACETATE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRASTERONE; PREGNENOLONE; PROGESTERONE; PROLACTIN; SEX HORMONE; TESTOSTERONE; VALPROIC ACID;

ALLERGIC REACTION; AMENORRHEA; ANORGASMIA; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; ENDOCRINE DISEASE; EPILEPSY; HORMONE METABOLISM; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMPOTENCE; INFERTILITY; LIBIDO DISORDER; LUTEAL PHASE; MENSTRUAL CYCLE; MENSTRUATION DISORDER; MONOTHERAPY; NEUROENDOCRINE SYSTEM; NONHUMAN; OLIGOMENORRHEA; OVARY FUNCTION; OVARY INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; QUALITY OF LIFE; REPRODUCTION; REVIEW; SEMEN ABNORMALITY; SEXUAL DEVELOPMENT; SEXUAL DYSFUNCTION; SEXUAL FUNCTION; SIDE EFFECT; TESTIS DISEASE; TESTIS FUNCTION; TESTOSTERONE BLOOD LEVEL; WEIGHT GAIN;

ANTICONVULSANTS; ENDOCRINE SYSTEM DISEASES; EPILEPSY; GONADAL STEROID HORMONES; GONADS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFERTILITY; PITUITARY DISEASES; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 43449104745     PISSN: 10747931     EISSN: None     Source Type: Journal    
DOI: 10.1097/NRL.0b013e3181618ada     Document Type: Review

References (187)

1. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993;34:453-468.
2. Friedman MN, Herzog AG. Epilepsy and disorders of reproduction. In: Ettinger AB, Devinsky O, eds, Managing Epilepsy and Co-existing Disorders. Boston: Butterworth/Heinemann; 2002:305-315.
3. Saberi N, Pourgholami MH, Jorjani M. The acute effects of estradiol benzoate on amygdala kindled seizures in male rats. Brain Res. 2001;891:1-6.
4. Murialdo G, Galimberti CA, Fonzi S, et al. Sex hormones and pituitary function in male epileptic patients with altered or normal sexuality, Epilepsia. 1995;36:360-365.
5. Reddy DS. Role of neurosteroids in catamenial epilepsy. Epilepsy Res. 2004;62:99-118.
6. Isojärvi JI, Löfgren E, Juntunen KS, et al. Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology. 2004;62:247-253.
7. Røste LS, Taubøll E, Morkrid L, et al. Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy. Eur J Neurol. 2005;12:118-124.
8. Hamed SA, Mohamed KA, EL-taher AM, et al. The sexual and reproductive health in men with generalized epilepsy: a multidisciplinary evaluation. Int J Impotence Res. 2006;18:287-295.
9. Harden CL. Sexuality in men and women with epilepsy. CNS Spectr. 2006;11(8 Suppl 9):13-18.
10. Morrell MJ, Flynn KL, Seale CG, et al. Reproductive dysfunction in women with epilepsy: antiepileptic drug effects on sex-steroid hormones. CNS Spectrums. 2001;6:771-786.
11. Herzog AG, Fowler KM. Sexual hormones and epilepsy: threat and opportunities. Curr Opin Neurol. 2005;18:167-172.
12. Hamed SA, Hamed EA, Shokry M, et al. The reproductive conditions and lipid profile in females with epilepsy. Acta Neurol Scand. 2007;115:1-12.
13. Dana-Haeri J, Oxley J, Richins A. Reduction of free testosterone by antiepileptic drugs. Br Med J (Clin Res Ed). 1982;284:85-86.
14. Herzog AG. A hypothesis to integrate partial seizures of temporal lobe origin and reproductive endocrine disorders. Epilepsy Res. 1989;3:151-159.
15. Bauer J, Isojärvi JIT, Herzog AG, et al. Reproductive dysfunction in women with epilepsy: recommendations for evaluation and management. J Neurol Neurosurg Psychiatry. 2002;73:121-125.
16. Hoffman GE, Moore N, Fiskum G, et al. Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment. Exp Neurol. 2003;182:124-134.
17. Veliškova J. The role of estrogens in seizures and epilepsy: the bad guys or the good guys? Neuroscience. 2006;138:837-844.
18. Logothetis J, Harner R. Electrocortical activation by estrogens. Arch Neurol. 1960;3:290-297.
19. Hom AC, Buterbaugh GG. Estrogen alters the acquisition of seizures kindled by repeated amygdala stimulation or pentylenetetrazol administration in ovarectomized female rats. Epilepsia. 1986;27:103-108.
20. Hardy RW. Unit activity in premarin-induced cortical epileptogenic foci. Epilepsia. 1970;11:179-186.
21. Gevorkyan ES, Nazaryan KB, Kostanyan AA. Modifying effect of estradiol and progesterone on epileptic activity of the rat brain. Neurosci Behav Physiol. 1989;19:412-415.
22. Edwards HE, Burnham WM, Mendonca A, et al. Steroid hormones affect limbic afterdischarge thresholds and kindling rates in adult female rats. Brain Res. 1999;838:136-150.
23. Harden CL, Koppel BS, Herzog AG, et al. Seizure frequency is associated with age at menopause in women with epilepsy. Neurology. 2003;61:451-455.
24. Veliškova J, Velisek L, Galanopoulou AS, et al. Neuroprotective effects of estrogens on hippocampal cells in adult female rats after status epilepticus. Epilepsia. 2000;41:S30-S35.
25. Kalkbrenner KA, Standley CA. Estrogen modulation of NMDA-induced seizures in ovariectomized and non-ovariectomized rats. Brain Res. 2003;964:244-249.
26. Jacono JJ, Robertson JMD. The effects of estrogen, progesterone and ionized calcium on seizures during the menstrual cycle of epileptic women. Epilepsia. 1987;28:571-577.
27. Peebles CT, McAuley JW, Moore JL, et al. Hormone replacement therapy in a postmenopausal women with epilepsy. Ann Pharmacother. 2000;34:1028-1031.
28. Weaver CE Jr, Park-Chung M, Gibbs TT, et al. 17 Beta-estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors. Brain Res. 2000;761:338-341.
29. Briellmann RS, Berkovic SF, Jackson GD. Men may be more vulnerable to seizure-associated brain damage. Neurology. 2000;55:1479-1485.
30. Pike CJ. Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease. J Neurochem. 1999;72:1552-1563.
31. Sawada H, Ibi M, Kihara T, et al. Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons. FASEB J. 2000;14:1202-1214.
32. Multhaup G, Ruppert T, Schlicksupp A, et al. Reactive oxygen species and Alzheimer's disease. Biochem Pharmacol. 1997;54:533-539.
33. Bishop J, Simpkins JW. Role of estrogens in peripheral and cerebral glucose utilization. Rev Neurosci. 1992;3:121-137.
34. Velis?kova J. The role of neuropeptide Y in estrogen-induced neuroprotective effects on status epilepticus-associated hippocampal loss. Epilepsia. 2003;44:206.
35. Singh M, Setalo G, Guan X Jr, et al. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J Neurosci. 1999;19:1179-1188.
36. Mensah-Nyagan AG, Do-Rego JL, Beaujean D, et al. Neurosteroids; expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system. Pharmacol Rev. 1999;51:63-81.
37. Stoffel-Wagner B. Neurosteroid biosynthesis in the human brain and its clinical implications. Ann N Y Acad Sci. 2003;1007:64-78.
38. Baulieu EE. Neurosteroids: novels function of the brain. Psychoneuroendocrinology. 1998;23:963-987.
39. Pierson RC, Lyons AM, Greenfield LJ Jr. Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N. Neurons 2005;138:105-115.
40. Compagnone NA, Mellon SH. Neurosteroids: biosynthesis and function of these novel neuromodulators. Front Neuroendocrinol. 2000;21:1-56.
41. Frye CA, Scalise TJ. Anti-seizure effects of progesterone and 3alpha, 5alpha-THP in kainic acid and perforant pathway models of epilepsy. Psychoneuroendocrinology. 2000;25:407-420.
42. Beyenburg S, Stoffel-Wagner B, Bauer J, et al. Neuroactive steroids and seizure susceptibility. Epilepsy Res. 2001;44:141-153.
43. Bickerstaff E. Neurological Complications of Oral Contraceptives. Oxford: Clarendon Press; 1975.
44. Frye CA, Scalise TJ, Bayon LE. Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity. J Neuroendocrinol. 1998;10:291-296.
45. Friedman L, Gibbs TT, Farb DH. Gamma-aminobutyric acid A receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. Mol Pharmacol. 1993;44:191-197.
46. Martini L, Melcangi RC, Maggi R. Androgen and progesterone metabolism in the central and peripheral nervous system. J Steroid Biochem Mol Biol. 1993;47:195-205.
47. Gulinello M, Gong QH, Li X, et al. Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female rat. Brain Res. 2001;910:55-66.
48. Galli R, Luisi M, Pizzanelli C, et al. Circulating levels of allopregnanolone, an anticonvulsant metabolite of progesterone, in women with partial epilepsy in the postcritical phase. Epilepsia. 2001;42:216-219.
49. Cai Z, Fratkin JD, Rhodes PG. Prenatal ischemia reduces neuronal injury caused by neonatal hypoxia-ischemia in rats. Neuroreport. 1997;8:1393-1398.
50. Murialdo G, Galimberti CA, Fonzi S, et al. Sex hormones, gonadotropins and prolactin in male eplileptic subjects in remission: role of epileptic syndromes and epileptic drugs. Neuropsychobiology. 1994;30:29-36.
51. Rogawski MA, Löscher W. The neurobiology of anti-epileptic drugs. Nat Rev Neurosci. 2004;20045:553-564.
52. Leiderman DB, Csernansky JG, Moses JA Jr. Neuroendocrinology and limbic epilepsy: relationships to psychopathology, seizure variables, and neuropsychological function. Epilepsia. 1990;31:270-274.
53. Reddy DS. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol. Neuroscience. 2004;129:195-207.
54. Saberi N, Jorjani M, Pourgholami MH. Effects of chronic estradiol benzoate treatment on amygdala kindled seizures in male rats. Epilepsy Res. 2001;46:45-51.
55. Herzog AG, Seibel MM, schomer DL, et al. Reproduction endocrine disorders in men with partial seizures of temporal lobe origin. Arch Neurol. 1986;43:347-350.
56. Luthold WW, Borges MF, Marcondes JA, et al. Serum testosterone fractions in women: normal and abnormal clinical states. Metabolism. 1993;42:638-643.
57. Woolley CS, Gould E, Frankfurt M, et al. Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons. J Neurosci. 1990;10:4035-4039.
58. Zamani MR, Levy WB, Desmond NL. Estradiol increases delayed, N-methyl-D-aspartate receptor-mediated excitation in the hippocampal CA1 region. Neuroscience. 2004;129:243-254.
59. Rudick CN, Woolley CS. Estrogen regulates functional inhibition of hippocampal CA1 pyramidal cells in adult female rat. J Neurosci. 2001;21:6532-6543.
60. + current in hippocampal pyramidal neurons. J Neurosci. 2003;23:6338-6344.
61. Frye CA. The neurosteroid 3α,5α-THP has anti-seizure and possible neuroprotective effects in an animal model of epilepsy. Brain Res. 1995;696:113-120.
62. Foldvary-Schaefer N, Falcone T. Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology. 2003;61:S2-S15.
63. Murri L, Galli R. Catamenial epilepsy, progesterone and its metabolites. Cephalalgia. 1997;17:S20:46-47.
64. Liporace J, D'Abreu A. Epilepsy and women's health: family planning, bone health, menopause, and menstrual-related disorders. Mayo Clin Proc. 2003;78:497-506.
65. Herkes GK, Eadie MJ, Sharbrough F, et al. Patterns of seizure occurrence in catamenial epilepsy. Epilepsy Res. 1993;15:47-52.
66. Herzog AG, Klein P, Ransil BJ. Three patterns of catamenial epilepsy. Epilepsia. 1997;38:1082-1088.
67. Bäckstrom T. Epileptic seizures in women in relation to variations of plasma estrogen and progesterone during the menstrual cycle. Acta Psych Scan. 1976;54:321-347.
68. Reddy DS, Rogawski MA. Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. Epilepsia. 2001;42:337-344.
69. Schwartzkroin PA, Baraban SC, Hochman DW. Osmolarity, ionic flux, and changes in brain excitability. Epilepsy Res. 1998;32:275-285.
70. Genazzani AR, Lemarchand-Beraud T, Aubert ML, et al. Pattern of plasma ACTH, hCH, and cortisol during menstrual cycle. J Clin Endocrinol Metab. 1975;42:431-437.
71. Frye CA, Rhodes ME. Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone. Pharmacol Biochem Behav. 2005;81:907-916.
72. Mattson RH, Cramer JA. Epilepsy, sex hormones, and antiepileptic drugs. Epilepsia. 1985;26(Suppl 1):S40-S51.
73. Bauer J, Dienel A, Elger CE. Losigamone add-on therapy in partial epilepsy: a placebo-controlled study. Acta Neurol Scand. 2001;103:226-230.
74. Maguire JL, Stell BM, Rafizadeh M, et al. Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci. 2005;8:797-804.
75. Nakamura NH, Rosell DR, Akama KT, et al. Estrogen and ovariectomy regulate mRNA and protein of glutamic acid decarboxylases and cation-cloride cotransporters in the adult rat hippocampus. Neuroendocrinology. 2004;80:308-323.
76. McEwen BS. Neuroendocrine interactions. In: Bloom FE, Kupfer J, eds. Psychopharmacology. New York: Raven press; 1995:705-717.
77. Gee NS, Brown JP, Dissanayake VUK, et al. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem. 1996;271:5768-5776.
78. Rao SP, Sikdar SK. Estradiol-induced changes in the activity of hippocampal neurons in network culture are suppressed by co-incubation with gabapentin. Brain Res. 2004;45:1024-1036.
79. Lim LL, Foldvary N, Mascha E, et al. Acetazolamide in women with catamenial epilepsy. Epilepsia. 2001;42:746-749.
80. Garcia-Segura LM, Azoitia I, Doncarlos LL. Neuroprotection by estradiol. Prog Neurobiol. 2001;63:29-60.
81. Bolton JL, Pisha E, Zhang F, et al. Role of quinoids in estrogen carcinogenesis. Chem Res Toxicol. 1998;11:1113-1127.
82. Olsson HL, Ingvar C, Bladstrom A. Hormone replacement therapy containing progestins and given continuously increases breast carcinoma risk in Sweden. Cancer. 2003;97:1387-1392.
83. Nisen J, Brinton RD. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology. 2002;143:205-212.
84. Scharfman HE, MacLusky NJ. The influence of gonadal hormones on neuronal excitability, seizures and epilepsy in the female. Epilepsia. 2006;47:1423-1440.
85. Stoffel-Wagner B, Bauer J, Flugel D, et al. Serum sex hormones are altered in patients with chronic temporal lobe epilepsy receiving anticonvulsant medication. Epilepsia. 1998;39:1164-1173.
86. Schacter SC. Neuroendocrine aspects of epilepsy. Neurol Clin. 1994;12:31-39.
87. Bauer J, Blumenthal S, Reuber M, et al. Epilepsy syndrome, focus, location, and treatment choice affect testicular function in men with epilepsy. Neurology. 2004;62:174-175.
88. Bilo L, Meo R, Nappi C, et al. Reproductive endocrine disorders in women with primary generalized epilepsy. Epilepsia. 1988;29:612-619.
89. Quigg M, Kiely JM, Shaneker B, et al. Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men. Ann Neurol. 2002;51:559-566.
90. Morrell MJ, Montouris GD. Reproductive disturbances in patients with epilepsy. Cleve Clin J Med. 2004;71(Suppl 2):S19-S24.
91. Mahesh VB, Brann DW. Regulation of the preovulatory gonadotropin surge by endogenous steroids. Steroids. 1998;63:616-629.
92. Baird AD, Wilson SJ, Bladin PF, et al. The amygdala and sexual drive: insights from temporal lobe epilepsy surgery. Ann Neurol. 2004;55:87-96.
93. Löfgren E, Mikkonen K, Tolonen U, et al. Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication. Epilepsy Behav. 2007;10:77-83.
94. Souza EAP, Keiralla DMB, Silveira DC, et al. Sezual dysfunction in epilepsy: identifying psychological variables. Arq Qneuropsiquiatr. 2000;58:214-220.
95. Smith DF, Baker GA, Dewey M, et al. Seizure frequency, patient-perceived seizure severity and the psychosocial consequencies of intractable epilepsy. Epilepsy Res. 1991;9:231-241.
96. Montouris G, Morris GL III. Reproductive and sexual dysfunction in men with epilepsy. Epilepsy Behav. 2005;7(Suppl 2):S7-S14.
97. Kuba R, Pohanka M, Zakopcan J, et al. Sexual dysfunctions and blood hormonal profile in men with focal epilepsy. Epilepsia. 2006;47:2135-2140.
98. Yung WKA, Janys T. Primary neurological tumors. In: Goetz CG, Pappert EJ, eds, Textbook of Clinical Neurology. Philadelphia: WB Saunders; 1999:948-956.
99. Baird AD, Wilson SJ, Bladin PF, et al. Sexual outcome after epilepsy surgery,. Epilepsy Behav. 2003;4:268-278.
100. Collins WCJ, Lanigan O, Callaghan N. Plasma prolactin concentrations following epileptic and pseudoseizures. J Neurol Neurosurg Psychiatry. 1983;46:505-508.
101. Sperling MR, Pritchard PB, Engel J, et al. Prolactin in partial epilepsy: an indicator of limbic seizures. Ann Neurol. 1986;20:716-722.
102. Molaie M, Culebras A, Miller M. Nocturnal plasma prolactin rise in patients with complex partial seizures. Ann Neurol. 1985;18:719-722.
103. Morrell MI. Epilepsy in women. Am Fam Physician. 2002;66:1489-1495.
104. Bilo L, Meo R, Valentino R, et al. Characterization of the reproduction endocrine disorders in women with epilepsy. J Clin Endocrinol Metab. 2001;86:2950-2956.
105. Herzog AG, Coleman AE, Jacobs AR, et al. Relationship of sexual dysfunction to epilepsy laterality and reproductive hormone levels in women. Epilepsy Behav. 2003;4:407-413.
106. Herzog AG, Coleman AE, Jacobs AR, et al. Interictal EEG discharges, reproductive hormones, and menstrual disorders in epilepsy. Ann Neurol. 2003;54:625-637.
107. Murialdo G, Galimberti CA, Magri F, et al. Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy. J Endocrinol Invest. 1997;20:519-526.
108. Klein P, Serje A, Pezzullo JC. Premature ovarian failure in women with epilepsy. Epilepsia. 2001;42:1582-1589.
109. Cummings LN, Giudice L, Morrell MMJ. Ovulatory function in epilepsy. Epilepsia. 1995;36:355-359.
110. Morris GL III, Vanderkolk C. Human sexuality, sex hormones, and epilepsy. Epilepsy Behav. 2005;7(Suppl 2):S22-S28.
111. Isojärvi JI, Laatikainen TJ, Pakarinen AJ, et al. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med. 1993;329:1383-1388.
112. Fenwick PB, Toone BK, Wheeler MJ, et al. Sexual behavior in a centre for epilepsy. Acta Neurol Scand. 1985;71:428-435.
113. Bone B, Janszky J. Epilepsy and male sexual dysfunction: etiology, diagnosis and therapy. Ideggyogy Sz. 2006;59:148-152.
114. Herzog AG. Reproductive endocrine considerations and hormonal therapy for men with epilepsy. Epilepsia. 1991;32:S24-S37.
115. Pitchard PB. Hyposexuality: a complication of complex partial epilepsy. Trans Am Neurol Assoc. 1980;105:193-195.
116. Morrell MJ, Sperling MR, Stecker, et al. Sexual dysfunction in partial epilepsy. Neurology. 1994;44:243-247.
117. Duncan S, Blacklaw J, Beastall GH, et al. Antiepileptic drug therapy and sexual function in men with epilepsy. Epilepsia. 1999;40:197-204.
118. Temin PA, Mukhin KIu. Sex disorders in men with epilepsy. Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91:47-50.
119. Taneja N, Kucheria K, Jain S, et al. Effect of phenytoin on semen. Epilepsia. 1994;35:136-140.
120. Toone BK, Wheeter M, Nanjee M, et al. Sex hormones, sexual activity and plasma anticonvulsant levels in male epileptics. J Neurol Neurosurg Psychiatry. 1983;44:242-247.
121. Davidson JM, Camargo CA, Smith ER. Effects of androgen on sexual behavior in hypgonadal men. J Clin Endocrinol Metabol. 1979;48:955-958.
122. Rubinow DR, Schmidt PJ. Androgens, brain, and behavior. Am J Psychiatry. 1996;153:974-984.
123. Isojärvi JI, Repro M, Pakarinen AJ, et al. Carbamazepine, phenytoin, sex hormones and sexual function in men with epilepsy. Epilepsia. 1994;36:366-370.
124. Duncan S, Blacklaw J, Beastall GH, Brodie MJ. Sexual function in women with epilepsy. Epilepsia. 1997;38:1074-1081.
125. Morrell MJ, Guldner GT. Self-reported sexual function and sexual arousability in women with epilepsy. Epilepsia. 1996;37:1204-1210.
126. Christianson AS, Silfevenius H, Saisa J, et al. Life satisfaction and sexuality in patients operated for epilepsy. Acta Neurol Scand. 1995;92:1-6.
127. Daniele A, Azzoni A, Bizzi A, et al. Sexual behavior and hemispheric laterality of the focus in patients with temporal lobe epilepsy. Biol Psychiatry. 1997;42:617-624.
128. Rättyä J, Turkka J, Pakarinen AJ, et al. Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology. 2001;56:31-36.
129. Löfgren E, Tapanainen JS, Koivunen R, et al. Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy. Epilepsia. 2006;47:1441-1446.
130. Petra P. The plasma sex steroids binding protein (SBP or SHBG). A critical review of recent developments on the structure, molecular biology and function. J Steroid Biochem Mol Biol. 1991;40:735-773.
131. Connell JM, Rapeport WG, Beastall GH, et al. Changes in circulating androgens during short term carbamazepine therapy. Br J Clin Pharmacol. 1984;17:347-351.
132. Isojärvi JI, Pakarinen AJ, Rautio A, et al. Serum sex hormone levels after replacing carbamazepine with oxcarbazepine. Eur J Clin Pharmacol. 1995;47:461-464.
133. Perucca E, Hedges A, Makki KA, et al. Richens, a comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. Br J Clin Pharmacol. 2004;58:S854-S863.
134. Murialdo G, Galimberti CA, Gianelli MV, et al. Effects of valproate, phenobarbital, and carbamazepine on sex steroid setup in women with epilepsy. Clin Neuropharmacol. 1998;21:52-58.
135. Isojärvi JIT, Pakarinen AJ, Ylipalosaari PJ, et al. Serum hormones in male patients with epilepsy patients receiving anticonvulsant medication. Arch Neurol. 1990;47:670-676.
136. Isojärvi JI, Tauboll E, Herzog AG. Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy. CNS Drugs. 2005;19:207-223.
137. Labrie F, Belanger A, Cusan L, et al. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab. 1997;63:243-245.
138. Drislane FW, Coleman AE, Schomer DL, et al. Altered pulsatile secretion of luteinizing hormone in women with epilepsy. Neurology. 1994;44:306-310.
139. Curtis VL, Oelberg DG, Willmore LJ. Infertility secondary to valproate. J Epilepsy. 1994;7:259-261.
140. Yerby MS, McCoy GB. Male infertility: possible association with valproate exposure. Epilepsia. 1999;40:520-521.
141. Røste LS, Taubøll T, Haugen TB, et al. Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy. Eur J Neurol. 2003;10:501-506.
142. Schutte B. New diagnostic procedures in assessing male fertility. Zeitschrift Für Hautkrankheiten. 1989;292:295-298.
143. Gobello S, Castex G, Corrada Y. Serum and seminal markers in the diagnosis of disorders of the genital tract of the dog: a mini-review. Theriogenology. 2002;57:1285-1291.
144. Jeulin C, Lewin LM. Role of free L-Carnitine and acetyl-L-Carnitine in post-gonadal maturation of mammalian spermatozoa. Hum Reprod Update. 1996;2:89-102.
145. Van Wouwe JP. Carnitine deficiency during valproic acid treatment. Int J Vitam Nutr Res. 1995;65:211-214.
146. Røste LS, Taubøll E, Berner AA, et al. Morphological changes in the testis after long-term valproate treatment in male Wistarrats. Seizure. 2001;10:559-565.
147. Stephen LJ, Kwan P, Shapiro D, et al. Hormone profiles of young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy. Epilepsia. 2001;42:1002-1006.
148. Vainionpaa LK, Rättyä J, Knip M, et al. Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy. Ann Neurol. 1999;45:444-450.
149. Svalheim S, Tauboll E, Bjornenak T, et al. Do women with epilepsy have increased frequency of menstrual disturbances? Seizure. 2003;12:529-533.
150. El-Khayat HA, Abd El-Basset FZ, Tomoum HY, et al. Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy. Epilepsia. 2004;45:1106-1115.
151. Isojärvi JI. Reproductive dysfunction in women with epilepsy. Neurology. 2003;61(6 Suppl 2):S27-S34.
152. Morrell MJ, Isojärvi J, Taylor AE, et al. Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. Epilepsy Res. 2003;54:189-199.
153. Luef G, Abraham I, Trinka E, et al. Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate. Epilepsy Res. 2002;48:91-102.
154. Yen SSC. Polycystic ovary syndrome (hyperandrogenic chronic anovulation). In: Yen SSC, Jaffe RB, Barbieri RL, eds. Reproductive Endocrinology, 4th ed. Philandelphia: WB Saunders; 1999:436-478.
155. Røste LS, Taubøll E, Isojärvi JI, et al. Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats. Reprod Toxicol. 2002;16:767-773.
156. Isojarvi JI, Tauboll E, Pakarinen AJ, et al. Altered ovarian function and cardiovascular risk factors in valproate-treated women. Am J Med. 2001;111:290-296.
157. Hamed SA. Leptin and insulin homeostasis in epilepsy: relation to weight adverse conditions. Epilepsy Res. 2007;75:1-9.
158. Taubøll E, Gregoraszczuk EL, Kolodziej A, et al. Valproate inhibits the conversion of testosterone to estradiol and acts as an apoptotic agent in growing pocrine ovarian follicular cells. Epilepsia. 2003;44:1014-1021.
159. Schneck CD, Thomas MR, Gundersen D. Sexual side effects associated with valproate. J Clin Psychopharmacol. 2002;22:532-534.
160. Maes M, Calabrese JR. Mechanisms of action of valproate in affective disorders. In: Joffe RT, Calabrese JR, eds. Anticonvulsants in Mood Disorders. New York: Marcel Dekker; 1994:100-101.
161. Grant AC, Oh H. Gabapentin-induced anorgasmia in women [letter to the editor]. Psychiatry. 2002;159:1247.
162. Luine NV, Wu V, Hoffman CS, et al. GABAergic regulation of lordosis: influence of gonadal hormones on turnover of GABA and interaction of GABA with 5-HT. Neuroendocrinology. 1999;69:438-445.
163. Elger CE, Bauer J. New antiepileptic drugs in epileptology. Neuropsychobiology. 1998;38:145-148.
164. Schachter SC. Oxcarbazepine: current status and clinical applications. Expert Opin Investig Drugs. 1999;8:1103-1112.
165. Pack A. Effects of treatment on endocrine function in patients with epilepsy. Curr Treat Options Neurol. 2005;7:273-280.
166. Bennett GD, Amore BM, Finnell RH, et al. Teratogenicity of carbamazepine-10, 11-epoxide and oxcarbazepine in the SWV mouse. J Pharmacol Exp Ther. 1996;279:1237-1242.
167. Artama M, Isojärvi JI, Raitanen J, et al. Birth rate among patients with epilepsy: a nationwide population-based cohort study in Finland. Am J Epidemiol. 2004;159:1057-1063.
168. Fitton A, Goa KL. Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy. Drugs. 1995;50:691-713.
169. Williams SCR, Meldrum BS, Pratt DG, et al. Lamotrigine reduces post-ictal CNS damage in the pilocarpine model of seizures. Epilepsia. 2000;S41:175.
170. Herzog AG, Drislane FW, Schomer DL, et al. Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs. Epilepsia. 2004;45:764.
171. Husain AM, Carwile ST, Miller PP, et al. Improved sexual function in three men taking lamotrigine for epilepsy. S Med J. 2000;93:335-336.
172. Gil-Nagel A, Lopez-Munoz F, Serratosa JM, et al. Effect of lamotrigine on sexual function in patients with epilepsy. Seizure. 2006;15:142-149.
173. Silva HC, Carvalho MJ, Jorge CL, et al. Sexual disorders in epilepsy. Results of a multidisciplinary evaluation. Arq Qneuropsiquiatr. 1999;57:798-807.
174. Isojarvi JI, Rättyä J, Myllyla VV, et al. Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy. Ann Neurol. 1998;43:446-451.
175. Ribacoba-Montero R, Martinez-Faedo C, Diaz-Diaz C, et al. Remission of polycystic ovary syndrome associated with valproic acid in an epileptic female. Rev Neurol. 2003;36:639-642.
176. Goodwin GM, Bowden CL, Calabrese GR, et al. A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry. 2004;65:432-441.
177. Mazer NA. Testosterone deficiency in women: etiologies, diagnosis, and emerging treatments. Int J Fertil Womens Med. 2002;47:77-86.
178. Herzog AG, Klein P, Jacobs AR. Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism. Neurology. 1998;50:782-784.
179. Harden C, MacLusky NJ. Aromatase inhibitors as add-on treatment for men with epilepsy. Expert Rev Neurother. 2005;5:123-127.
180. Penovich P. The effects of epilepsy and its treatment on sexual and reproductive function. Epilepsia. 2000;41(Suppl. 2):S53-S61.
181. Davidson JM, Kwan M, Greeleaf WJ. Hormonal replacement and sexuality in men. Clin Endocrinol Metabol. 1982;11:599-623.
182. Mazer NA, Shifren JL. Transdermal testosterone for women: a new physiological approach for androgen therapy. Obstet Gynecol Surv. 2003;58:489-500.
183. Moynihan R. FDA panel rejects testosterone patch for women on safety grounds. Br Med J. 2004;329:1363.
184. Azcoitia I, Sierra A, Veiga S, et al. Brain aromatase is neuroprotective. J Neurobiol. 2001;47:318-329.
185. Laan E, van Lunsen RH, Everaerd W, et al. The enhancement of vaginal vasocongestion by sildenafil in healthy premenopausal women,. J Womens Health Gend Based Med. 2002;11:357-365.
186. Nurnberg HG, Hensley PL, Lauriello J, et al. Sildenafil for women patients with antidepressant-induced sexual dysfunction. Psychiatr Serv. 1999;50:1076-1078.
187. Lambert MV. Seizures, hormones and sexuality. Seizure. 2001;10:319-334.