Circulating levels of allopregnanolone, an anticonvulsant metabolite of progesterone, in women with partial epilepsy in the postcritical phase

Epilepsia

Volumn 42, Issue 2, 2001, Pages 216-219

  Galli, Renato ^a,b   Luisi, Michele ^a   Pizzanelli, Chiara ^a   Monteleone, Patrizia ^a   Casarosa, Elena ^a   Iudice, Alfonso ^a   Murri, Luigi ^a  

^a UNIVERSITY OF PISA   (Italy)

^b NONE   (Italy)

Author keywords

Allopregnanolone; Epilepsy; Neurosteroids; Postictal; Women

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID RECEPTOR; ESTROGEN; NEUROSTEROID; PROGESTERONE;

ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; EPILEPTOGENESIS; FEMALE; FOCAL EPILEPSY; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HUMAN; NERVE CELL EXCITABILITY; PRIORITY JOURNAL; PROGESTERONE METABOLISM; SEIZURE THRESHOLD;

ADULT; AGE OF ONSET; ANTICONVULSANTS; CEREBRAL CORTEX; ELECTROENCEPHALOGRAPHY; EPILEPSIES, PARTIAL; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PREGNANOLONE; PROGESTERONE; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0035097212     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2001.07600.x     Document Type: Article

References (28)

1. The role of estrogens in catamenial exacerbation of epilepsy
2. Electrocortical activation by estrogens
3. Epileptic seizures in women related to plasma estrogens and progesterone during the menstrual cycle
4. Effect of i.v. progesterone infusions on epileptic discharge frequency in women with partial epilepsy
5. Seizures and menstrual cycle
6. Temporal distribution of seizures in epilepsy
7. Analysis of seizure dispersion during menstrual cycle in women with epilepsy
8. How common is catamenial epilepsy?
9. The effect of menstruation on seizure incidence
10. Unbalanced progesterone and estradiol secretion in catamenial epilepsy
11. Three patterns of catamenial epilepsy
12. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
13. Characterization of steroid interaction with γ-aminobutyric acid receptor-gated chloride ion channels: Evidence for multiple steroid recognition sites
14. Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex
15. Neuroactive steroids
16. The effect of progesterone and its metabolites on the interictal epiteptiform discharge in the cat's cerebral cortex
17. Evidence that 5α-pregnan-3α-ol-20-one is the metabolite responsible for progesterone anesthesia
18. Circulating levels of anticonvulsant metabolites of progesterone in women with partial epilepsy in the intercritical phase
19. Proposal for revised classification of epilepsies and epileptic syndromes
20. Aging is associated with changes in allopregnanolone concentration in brain, endocrine glands and serum in male rats
21. 5α-Pregnan-3α-ol-20-one blocks nicotine-induced seizures and enhanced paired-pulse inhibition
22. Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice
23. Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain
24. Progesterone. 5αpregnane-3.20-dione and 3α-hydroxy-5α-pregnane-20-one in specific regions of the human female brain in different endocrine states
25. Progesterone metabolite allopregnanolone in women with premenstrual syndrome
26. GABA (A) receptor alpha 4 subunit suppression prevents withdrawal properties of an endogenous steroid
27. The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus
28. Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABA-A receptors