Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity

Journal of Neuroendocrinology

Volumn 10, Issue 4, 1998, Pages 291-296

  Frye, Cheryl A ^a   Scalise, Trudy J ^a   Bayon, Laura E ^a  

^a The Holleran Center for Community Action and Public Policy   (United States)

Author keywords

5 pregnan 3 ol 20 one (3 ,5 THP); Hippocampus; Neuroprotection; Neurosteroid; Non genomic; Non transcriptional; Progesterone

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ESTRADIOL BENZOATE; FINASTERIDE; PROGESTERONE; STEROID 5ALPHA REDUCTASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIESTRUS; ESTRUS; FEMALE; HIPPOCAMPUS; MAZE TEST; NERVE CELL NECROSIS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; CELL COUNT; DIESTRUS; ENZYME INHIBITORS; ESTRUS; FEMALE; FINASTERIDE; GABA MODULATORS; NEURONS; PERFORANT PATHWAY; PREGNANOLONE; RATS; SEIZURES; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0031976269     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1998.00202.x     Document Type: Article

References (58)

1. Satzinger G. Antiepileptics from γ-aminobutyric acid. Arzneim-Forsch/Drug Res 1994; 44: 261-66.
2. Franck JE, Kunkel DD, Baskin DG, Schwartzkroin PA. Inhibition in kainate-lesioned hyperexcitable hippocampi: physiologic, autoradiographic, and immunocytochemical observations. J Neurosci 1988; 88: 1991-2002.
3. Ribak CE. Neurocytology and chemistry in focal epilepsy. In: Pedley TA, Meldrum BS, eds. Recent Advances in Epilepsy, New York: Churchill Livingstone, 1986: 1-20.
4. Prince DA, Deisz RA, Thompson SM, Chagnac-Amitai Y. Functional alterations in GABAergic inhibition during activity. In: Avanzini G, Engel Jr J, Fariello R, Heinemann U, eds. Neurotransmitters in Epilepsy, Amsterdam: Elsevier Science Publishers, 1992: 31-8.
5. Wooley DE, Timiras PS. Estrous and circadian periodicity and electroshock convulsions in rats. Am J Physiol 1962; 202: 379-82.
6. Wooley D, Timiras PS. The gonad-brain relationship: effects of female sex-steroids on electroshock convulsions in the rat. Endocrinology 1962; 70: 196-209.
7. Timiras PS, Hill HF. Hormones and epilepsy. In: Glaser RH, Penry JK, Woodbury DM, eds. Antiepileptic Drugs: Mechanisms of Action, New York: Raven Press, 1980: 655-66.
8. Logothetis J, Harner R, Morrell F. The role of estrogens in catamenial exacerbation of eplilepsy. Neurology 1959; 9: 352-60.
9. Backstrom T. Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle. Acta Neurol Scand 1976; 54: 321-47.
10. Selye H. The antagonism between anesthetic steroid hormones and pentamethylenetetrazol (metrazol). J Lab Clin Med 1942; 27: 1051-3.
11. Spiegel E, Wycis H. Anticonvulsant effects of steroids. J Lab Clin Med 1945; 36: 947-53.
12. Craig CR. Anticonvulsant activity of steroids: seperability of anticonvulsant from hormonal effects. JPET 1966; 153: 337-43.
13. Blackham A, Spencer PSJ. Response of female mice to anticonvulsants after pretreatment with sex steroids. J Pharm Pharmacol 1970; 22: 204-305.
14. Landgren S, Backstrom T, Kalistratov G. The effect of progesterone on the spontaneous interjetai spike evoked by application of penicillen to the cat's cerebral cortex. J Neurol Sci 1978; 36: 119-33.
15. Backstrom T, Zetterlund B, Blom S, Romano M. Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy. Acta Neurol Scand 1984; 69: 240-48.
16. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 1986; 232: 1004-7.
17. Schwartz RD. The GABAA receptor-gated ion channel: Biochemical and pharmacological studies of structure and function. Biochem Pharmacol 1988; 37: 3369-75.
18. A receptor - mechanism of action and physiological significance. Prog Neurobiol 1992; 38: 379-95.
19. Pfaff DW, McEwen BS. Action of estrogens and progestins on nerve cells. Science 1983; 219: 808-14.
20. Laidlaw J. Catamenial epilepsy. Lancet 1956; 2: 1235-37.
21. Gallo MA, Smith SS. Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety. Pharmacol Biochem Behav 1993; 46: 897-904.
22. Gee KW, Boolger M, Brinton RE, Coirini H, McEwen BS. Steroid modulation of the chloride ionophore in rat brain: stucture-activity requirements, regional difference and mechanism of action. JPET 1988; 246: 803-12.
23. Holmes GL, Weber DA, Kloczko N, Zimmerman AW. Relationship of endocrine function to inhibition of kindling. Dev Brain Res 1987; 16: 55-9.
24. Belelli D, Bolger MB, Gee KW. Anticonvulsant profile of the progester-one metabolite 5α-pregnan-3α-ol-20-one. Eur J Pharmacol 1989; 166: 325-29.
25. Finn DA, Gee KW. The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. JPET 1994; 271: 164-70.
26. Frye CA. The neurosteroid 3α,5α-THP has anti-seizure and possible neuroprotective effects in an animal model of epilepsy. Brain Res 1995; 696: 113-20.
27. Landgren S, Aasly J, Backstrom T, Dubrovsky B, Danielson E. The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex. Acta Physiol Scand 1987; 131: 33-42.
28. Smith SS, Waterhouse BD, Woodward DJ. Sex steroid effects on extrahy-pothalamic CNS. I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum. Brain Res 1987; 422: 40-51.
29. Smith SS, Waterhouse BD, Woodward DJ. Sex steroid effects on extrahy-pothalamic CNS II. Progesterone, alone and in combination with estrogen, modulates cerebellar responses to amino acid neurotransmitters. Brain Res 1987; 422; 52-62.
30. Rosciszewska D, Buntner B, Guz I, Zawisza L. Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy. J Neurol Neurosurg Psych 1986; 49: 47-51.
31. Frye CA, Bayon LE. Increased seizure activity following precipitous decline in endogenous 3a,5a-THP. Neuroendocrinology 1997.
32. A receptor function. Pharmacol Biochem Behav 1993; 45: 423-28.
33. Smith HE, Smith RG, Toft DO, Neegard JR, Burrows EP, O'Malley BW. Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus. J Biol Chem 1974; 249: 5924-32.
34. Iswari S, Colas AE, Karavolas HJ. Binding of 5α-dihydroprogesterone and other progestins to female rat anterior pituitary nuclear extracts. Steroids 1986; 47: 189-203.
35. Karavolas HJ, Hodges DR. Neuroendocrine metabolism of progesterone and related progestins. In; Chadwick D, Widdows K, eds. Steroids and Neuronal Activity, Chichester: John Wiley & Sons, 1990; 153: 22-55.
36. Morrow AL, Pace JR, Purdy RH, Paul SM. Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Mol Pharmacol 1990; 37: 263-70.
37. Purdy RH, Morrow AL, Blinn JR, Paul SM. Synthesis, metabolism, and pharmacological activity of 3a-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes. J Med Chem 1990; 33: 1572-81.
38. Turner DM, Ransom RW, Yang J, Olsen RW. Steroid anesthetics and naturally occurring analogs modulate the GABA receptor complex at a distinct site from barbiturates. JPET 1989; 248: 960-66.
39. A receptor complex. JPET 1987; 241: 346-53.
40. Smith SS. Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells. Neuroscience 1991; 42: 309-20.
41. Brailowsky S, Menini C, Silva-Barrat C, Naquet R. Epileptogenic gamma-aminobutyric acid- withdrawal syndrome after chronic, intracortical infusion in baboons. Neurosci Lett 1987; 74: 75-80.
42. Buck KJ, McQuillen SJ, Harris RA. Modulation of GABA receptor operated chloride chanels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity. J Neurochem 1991; 57: 2100-5.
43. McCaslin PP, Morgan WM. Anticonvulsant activity of several excitatory amino acids antagonists against barbital withdrawal-induced spontaneous convulsions. Eur J Pharm 1988; 147: 381-6.
44. Purdy RH, Morrow AL, Moore PH, Paul SM. Stress-induced elevations of gamma-aminobutyric acid type-A receptor-active steroids in the rat brain. PNAS 1991; 88: 4553-7.
45. Wooley C, Gould E, Frankfurt M, McEwen BS. Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons. J Neurosci 1990; 10: 4035-9.
46. Brinton RD. The neurosteroid 3α-hydroxy-5α-pregnan-20-one induces cytoarchitectural regression in cultured fetal hippocampal neurons. J Neurosci 1994; 14: 2763-74.
47. Garcia-Estrada J, RJA, Luquin S, Soriano E, Garcia-Segura LM. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury. Brain Res 1993; 628: 271-8.
48. Loscher W, Horstermann D, Honack D, Rudfeldt C, Wahnschaffe U. Transmitter amino acid levels in rat brain regions after amygdala-kindling: evidence for a pro-kindling effect of prolonged electrode implantation. Neurochem Res 1993; 18: 775-81.
49. Knight AR, Bowery NG. GABA receptors in rats with spontaneous generalized nonconvulsive epilepsy. J Neural Trans 1992; 35: 189-96.
50. Bonuccelli U, Melis GB, Paoletti AM, Fioretti P, Murri L, Muratorio A. Unbalanced progesterone and estradiol secretion in catamenial epilepsy. Epilep Res 1989; 3: 100-6.
51. Narbone MC, Ruello C, Oliva A, Baviera G, d'Amico D, Bramanti P, DiPerri R. Hormonal disregulation and catamenial epilepsy. Fund Neurol 1989; 5: 49-53.
52. Isojarvi JIT, Laatikainen TJ, Pakarinen AJ, Juntunen KTS, Myllyla VV. Menstrual disorders in women with epilepsy receiving carbamazepine. Epilepsia 1995; 36: 676-81.
53. Kumar N, Behari M, Ahuja GK, Jailkhani BL. Phenytoin levels in catamenial epilepsy. Epilepsia 1988; 29: 155-8.
54. Frye CA. Estrus-associated decrements in a water maze task are limited to aquisition. Physiol Behav 1995; 102: 142-50.
55. Goodman RL. A quantitative analysis of the physiological role of estradiol and progesterone in the control of tonic and surge seceration of LH in the rat. Endocrinology 1978; 102: 142-50.
56. Brand T, Kroonen J, Mos J, Slob AK. Adult partner preference and sexual behavior of male rats affected by perinatal endocrine manipulations. Horm Behav 1991; 25: 323-41.
57. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Meth 1984; 11: 47-60.
58. Rodbard D, Hutt DM. Statistical analysis of radioimmunoassay and immunoradiometric assays: a generalized, weighted iterative, least squares method for logistic curve fitting. In: International Atomic Energy Agency, eds. Symposium on Radioimmunoassay and Related Procedures in Medicine, New York: Uniput, 1974.