Molecular understanding of oxygen-tension and patient-variability effects on ex vivo expanded T cells

Biotechnology and Bioengineering

Volumn 87, Issue 4, 2004, Pages 437-450

  Haddad, Hadar ^a   Windgassen, Dirk ^a   Ramsborg, Christopher G ^a   Paredes, Carlos J ^a   Papoutsakis, Eleftherios T ^a  

^a Northwestern University   (United States)

Author keywords

Cell therapy; Microarray; Ontological analysis; Oxidative stress; Quantitative RT PCR; ROS

Indexed keywords

BLOOD SAMPLES; CELL PROLIFERATION; LYMPHOCYTES; TRANSCRIPTION;

BIOMEDICAL ENGINEERING; BIOTECHNOLOGY; BLOOD SUBSTITUTES; GENES; IMMUNOLOGY; MOLECULAR STRUCTURE;

CELLS;

DNA; GRANZYME A; GRANZYME B; GRANZYME K; REACTIVE OXYGEN METABOLITE; RNA; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ARTICLE; CELL DEATH; CELL PROLIFERATION; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOTHERAPY; OXIDATIVE STRESS; OXYGEN TENSION; PHENOTYPE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; HUMANS; IMMUNOTHERAPY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXYGEN; T-LYMPHOCYTES; TISSUE THERAPY; VARIATION (GENETICS);

EID: 4344701645     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20166     Document Type: Article

References (62)

1. Baghdiguian S, Martin M, Richard I, Pons F, Astier C, Bourg N, Hay RT, Chemaly R, Halaby G, Loiselet J, et al. 1999. Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkappaB alpha/NF-kappaB pathway in limb-girdle muscular dystrophy type 2A. Nat Med 5:503-511.
2. Balaian LB, Moehler T, Montgomery AM. 2000. The human neural cell adhesion molecule L1 functions as a costimulatory molecule in T cell activation. Eur J Immunol 30:938-943.
3. Beresford PJ, Xia Z, Greenberg AH, Lieberman J. 1999. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. Immunity 10:585-594.
4. Berke G. 1994. The binding and lysis of target cells by cytotoxic lymphocytes: molecular and cellular aspects. Annu Rev Immunol 12:735-773.
5. Brand K, Leibold W, Luppa P, Schoerner C, Schulz A. 1986. Metabolic alterations associated with proliferation of mitogen-activated lymphocytes and of lymphoblastoid cell lines: evaluation of glucose and glutamine metabolism. Immunobiology 173:23-34.
6. Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, Sitkovsky MV. 2001. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J Immunol 167:6140-6149.
7. Carswell KS, Weiss JW, Papoutsakis ET. 2000. Low oxygen tension enhances the stimulation and proliferation of human T lymphocytes in the presence of IL-2. Cytotherapy 2:25-37.
8. Casagrandi D, Bearfield C, Geary J, Redman CW, Muttukrishna S. 2003. Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia. Mol Hum Reprod 9:199-203.
9. Chen LY, Chen JD. 2003. Daxx silencing sensitizes cells to multiple apoptotic pathways. Mol Cell Biol 23:7108-7121.
10. Coppock DL, Kopman C, Scandalis S, Gilleran S. 1993. Preferential gene expression in quiescent human lung fibroblasts. Cell Growth Differ 4:483-493.
11. Craven RS, Cance WG, Liu ET. 1995. The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. Cancer Res 55:3969-3972.
12. Curti BD, Ochoa AC, Powers GC, Kopp WC, Alvord WG, Janik JE, Gause BL, Dunn B, Kopreski MS, Fenton R and others. 1998. Phase I trial of anti-CD3-stimulated CD4+ T cells, infusional interleukin-2, and cyclophosphamide in patients with advanced cancer. J Clin Oncol 16:2752-2760.
13. de Groot RP, Coffer PJ, Koenderman L. 1998. Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. Cell Signal 10:619-628.
14. Defrance T, Carayon P, Billian G, Guillemot JC, Minty A, Caput D, Ferrara P. 1994. Interleukin 13 is a B cell stimulating factor. J Exp Med 179:135-143.
15. Demoulin JB, Van Roost E, Stevens M, Groner B, Renauld JC. 1999. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. J Biol Chem 274:25855-25861.
16. Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO. 2002. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci USA 99:11796-11801.
17. Eisen MB, Spellman PT, Brown PO, Botstein D. 1998. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95:14863-14868.
18. Ellisen LW, Palmer RE, Maki RG, Truong VB, Tamayo P, Oliner JD, Haber DA. 2001. Cascades of transcriptional induction during human lymphocyte activation. Eur J Cell Biol 80:321-328.
19. Fabio G, Zarantonello M, Mocellin C, Bonara P, Corengia C, Fargion S, Fiorelli G. 2002. Peripheral lymphocytes and intracellular cytokines in C282Y homozygous hemochromatosis patients. J Hepatol 37:753-761.
20. Fujiwara Y, Ohata H, Kuroki T, Koyama K, Tsuchiya E, Monden M, Nakamura Y. 1995. Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. Oncogene 10:891-895.
21. Goldstone SD, Fragonas JC, Jeitner TM, Hunt NH. 1995. Transcription factors as targets for oxidative signalling during lymphocyte activation. Biochim Biophys Acta 1263:114-122.
22. Gough NM, Williams RL. 1989. The pleiotropic actions of leukemia inhibitory factor. Cancer Cells 1:77-80.
23. Guyton A. 1996. Textbook of medical physiology, 9th ed. Philadelphia: W.B. Saunders. p 513-523.
24. Haddad H, Papoutsakis ET. 2001. Low oxygen tension and autologous plasma enhance T-cell proliferation and CD49d expression density in serum-free media. Cytotherapy 3:435-447.
25. Hamalainen H, Zhou H, Chou W, Hashizume H, Heller R, Lahesmaa R. 2001. Distinct gene expression profiles of human type 1 and type 2 T helper cells. Genome Biol 2:RESEARCH 0022.1-0022.11.
26. Han HJ, Tokino T, Nakamura Y. 1998. CSR, a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress. Hum Mol Genet 7:1039-1046.
27. Heslop HE, Rooney CM. 1997. Adoptive cellular immunotherapy for EBV lymphoproliferative disease. Immunol Rev 157:217-222.
28. Heyworth CM, Whetton AD, Nicholls S, Zsebo K, Dexter TM. 1992. Stem cell factor directly stimulates the development of enriched granulocyte-macrophage colony-forming cells and promotes the effects of other colony-stimulating factors. Blood 80:2230-2236.
29. Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA. 2003. Identifying biological themes within lists of genes with EASE. Genome Biol 4:R70.
30. Jones B, Roberts PJ, Faubion WA, Kominami E, Gores GJ. 1998. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line. Am J Physiol 275:G723-730.
31. Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, Kirshenbaum LA, Gibson SB. 2003. BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene 22:4734-4744.
32. Levine BL, Bernstein WB, Aronson NE, Schlienger K, Cotte J, Perfetto S, Humphries MJ, Ratto-Kim S, Birx DL, Steffens C, et al. 2002. Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nat Med 8:47-53.
33. Li X, Yang Y, Ashwell JD. 2002. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416:345-347.
34. Lin JX, Migone TS, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, et al. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331-339.
35. Los M, Droge W, Stricker K, Baeuerle PA, Schulze-Osthoff K. 1995. Hydrogen peroxide as a potent activator of T lymphocyte functions. Eur J Immunol 25:159-165.
36. Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G. 1999. Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Cell 99:747-755.
37. Naldini A, Carraro F. 1999. Hypoxia modulates cyclin and cytokine expression and inhibits peripheral mononuclear cell proliferation. J Cell Physiol 181:448-454.
38. Narayanan L, Fritzell JA, Baker SM, Liskay RM, Glazer PM. 1997. Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proc Natl Acad Sci USA 94:3122-3127.
39. Pahl HL, Baeuerle PA. 1994. Oxygen and the control of gene expression. Bioessays 16:497-502.
40. Perez-Martin J. 1999. Chromatin and transcription in Saccharomyces cerevisiae. FEMS Microbiol Rev 23:503-523.
41. Revell PA GW, Prior JL, Piwnica-Worms D, Ley TJ. 2003. Cytotoxic lymphocytes require granzymes for effective tumor cell killing in vivo [Abstract]. Blood 102:287a.
42. Riley JL, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, Gregson BP, June CH, Linsley PS. 2002. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci USA 99:11790-11795.
43. Rooney CM, Smith CA, Ng CY, Loftin SK, Sixbey JW, Can Y, Srivastava DK, Bowman LC, Krance RA, Brenner MK, et al. 1998. Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92:1549-1555.
44. Shresta S, Goda P, Wesselschmidt R, Ley TJ. 1997. Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. J Biol Chem 272:20236-20244.
45. Simon A, Fanburg B, Cochran B. 1997. Oxidative stress and cell proliferation. Clerch LB, editor. New York: Marcel Dekker.
46. Soutoglou E, Viollet B, Vaxillaire M, Yaniv M, Pontoglio M, Talianidis I. 2001. Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity. EMBO J 20:1984-1992.
47. Sporn JR, Ergin MT, Robbins GR, Cable RG, Silver H, Mukherji B. 1993. Adoptive immunotherapy with peripheral blood lymphocytes cocultured in vitro with autologous tumor cells and interleukin-2. Cancer Immunol Immunother 37:175-180.
48. Stevens C, Smith L, La Thangue NB. 2003. Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol 5:401-409.
49. Storz G, Polla BS. 1996. Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes. Exs 77:239-254.
50. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, et al. 1999. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99:71-80.
51. von Bulow GU, Bram RJ. 1997. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science 278:138-141.
52. Walker RE, Bechtel CM, Natarajan V, Baseler M, Hege KM, Metcalf JA, Stevens R, Hazen A, Blaese RM, Chen CC, et al. 2000. Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 96:467-474.
53. Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, Riddell SR. 1995. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 333:1038-1044.
54. Wang WJ, Kuo JC, Yao CC, Chen RH. 2002. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. J Cell Biol 159:169-179.
55. Yang W, de Bono DP. 1997. A new role for vascular endothelial growth factor and fibroblast growth factors: increasing endothelial resistance to oxidative stress. FEBS Lett 403:139-142.
56. Yang H, Haddad H, Tomas C, Alsaker K, Papoutsakis ET. 2003. A segmental nearest neighbor normalization and gene identification method gives superior results for DNA-array analysis. Proc Natl Acad Sci USA 100:1122-1127.
57. Yee KW, Moore SJ, Midmer M, Zanke BW, Tong F, Medley D, Minden MD. 2003. NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. Biochem Biophys Res Commun 308:784-792.
58. Yepes M, Sandkvist M, Wong MK, Coleman TA, Smith E, Cohan SL, Lawrence DA. 2000. Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. Blood 96:569-576.
59. Yu CL, Tsai CY, Lin WM, Liao TS, Chen HL, Sun KH, Chen KH. 1993. Tamm-Horsfall urinary glycoprotein enhances monokine release and augments lymphocyte proliferation. Immunopharmacology 26:249-258.
60. Yu Y, Xu F, Peng H, Fang X, Zhao S, Li Y, Cuevas B, Kuo WL, Gray JW, Siciliano M, et al. 1999. NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. Proc Natl Acad Sci USA 96:214-219.
61. Zelcer N, Reid G, Wielinga P, Kuil A, van der Heijden I, Schuetz JD, Borst P. 2003. Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J 371:361-367.
62. Zhang Y, Schlossman SF, Edwards RA, Ou CN, Gu J, Wu MX. 2002. Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice. Proc Natl Acad Sci USA 99:878-883.