Hypoxia modulates cyclin and cytokine expression and inhibits peripheral mononuclear cell proliferation

Journal of Cellular Physiology

Volumn 181, Issue 3, 1999, Pages 448-454

  Naldini, Antonella ^a   Carraro, Fabio ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 4;

ARTICLE; CELL HYPOXIA; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

CELL CYCLE; CELL DIVISION; CELL HYPOXIA; CYCLINS; CYTOKINES; DOWN-REGULATION; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MITOSIS; T-LYMPHOCYTES; UP-REGULATION;

EID: 0032746886     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199912)181:3<448::AID-JCP8>3.0.CO;2-F     Document Type: Article

References (31)

1. Aune TM, Pogue SL. 1989. Inhibition of tumor cell growth by interferon- g is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. J Clin Invest 84:863-875.
2. åmellem oø, Pettersen EO. 1993. Cell cycle progression in human cells following re-oxygenation after extreme hypoxia: consequences concerning initiation of DNA synthesis. Cell Proliferation 26:25-35.
3. Boyum A. 1968. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21:77-79.
4. Carmeliet P, Dor Y, Herbert J-M, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshet E. 1998. Role ofHIF-1 in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394:485-490.
5. Darzynkiewicz Z, Williamson B, Carswell EA, Old LJ. 1984. Cell cycle-specific effects of tumor necrosis factor. Cancer Res 44:83-90.
6. Firpo EJ, Koff A, Solomon MJ, Roberts JM. 1994. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol Cell Biol 14:4889-4901.
7. Grabstein K, Dower S, Gillis S, Urdal D, Larsen A. 1986. Expression of Interleukin 2, Interferon-g and the IL2 receptor by human peripheral blood lymphocytes. J Immunol 136:4503-4508.
8. Graeber TG, Peterson JF, Tsai M, Monica K, Fornace AJ Jr, Giaccia AJ. 1994. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol 14:6264-6277.
9. Gupta V, Eberle E. 1984. Modulation of tumor cell colony growth in soft agar by oxygen and its mechanism. Br J Cancer 49:587-590.
10. Horoszewicz JS, Leong SS, Carter WA. 1979. Noncycling tumor cells are sensitive targets for the antiproliferative activity of human interferon. Science 206:1091-1093.
11. Kallinowski F, Schlenger KH, Runkel S, Kloes M, Stohrer M, Okunieff P, Vaupel P. 1989. Blood flow, metabolism, cellular micro environment, and growth rate of human tumor xenografts. Cancer Res 49:3759-3764.
12. King KL, Cidlowski JA. 1998. Cell cycle regulation and apoptosis. Annu Rev Physiol 60:601-617.
13. Krtolica A, Krucher NA, Ludlow JW. 1998. Hypoxia-induced pRB hypophosphorylation results from down regulation of CDK and up regulation of PP1 activities. Oncogene 17:2295-2304.
14. Loeffler DA, Juneau PL, Masserant S. 1992. Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation. Br J Cancer 66:619-622.
15. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Method 65:55-63.
16. Mosmann TR. 1994. Interleukin-10. In: Thomson AW, editor. The cytokine handbook. U.K.: Academic Press. p 223-237.
17. Moulder JE, Rockwell S. 1987. Tumor hypoxia: its impact on cancer therapy. Cancer Metast Rev 5:313-341.
18. Naldini A, Carraro F, Bocci V. 1995. Effects of hypoxia on the antiproliferative activity of human interferons. J Interferon Cytokine Res 15:137-142.
19. Naldini A, Carraro F, Fleischmann WR, Jr, Bocci V. 1993. Hypoxia enhances the antiviral activity of interferons. J Interferon Res 13:127-132.
20. Naldini A, Carraro F, Silvestri S, Bocci V. 1997. Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells. J Cell Physiol 173:335-342.
21. Naldini A, Cesari S, Bocci V. 1994. Effects of hypoxia on the cytotoxicity mediated by TNF. Lymphokine Cytokine Res 13:233-237.
22. Noble MEM, Endicott JA, Brown NR, Johnson LN. 1997. The cyclin box fold: protein recognition in cell-cycle and transcription control. Trends Biochem Sci 22:482-487.
23. Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee M-H, Massague J, Crabtree GR, Roberts JM. 1994. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-573.
24. Petronini PG, Urbani S, Alfieri R, Borghetti AF, Guidotti GG. 1996. Cell susceptibility to apoptosis by glutamine deprivation and rescue: survival and apoptotic death in cultured lymphoma-leukemia cell lines. J Cell Physiol 169:175-185.
25. Powrie F, Coffman RL. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol Today 14:270-274.
26. Stefanelli C, Stanic I, Bonavita F, Muscari C, Pignatti C, Rossoni C, Caldarera CM. 1995. Oxygen tension influences DNA fragmentation and cell death in glucocorticoid-treated thymocytes. Biochem Biophys Res Commun 212:300-306.
27. Taylor IW, Hodson PJ. 1984. Cell cycle regulation by environmental pH. J Cell Physiol 121:517-525.
28. Terada N, Lucas JJ, Szepesi A, Franklin RA, Domenico J, Gelfand EW. 1993. Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle. J Cell Physiol 154:7-15.
29. Vaupel PW, Frinak S, Bicher HI. 1981. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma. Cancer Res 41:2008-2013.
30. Wagner EF, Hleb M, Hanna N, Sharma S. 1998. A pivotal role of cyclin D3 and cyclin-dependent kinase inhibitor p27 in the regulation of IL-2-, IL-4-, or IL-10-mediated human B cell proliferation. J Immunol 161:1123-1131.
31. Wang C-Y, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS, Jr. 1998. NF-kB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683.