DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals

Journal of Cell Biology

Volumn 159, Issue 1, 2002, Pages 169-179

  Wang, Won Jing ^a   Kuo, Jean Cheng ^a   Yao, Chung Chen ^a,b   Chen, Ruey Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Adhesion; Anoikis; Apoptosis; DAP kinase; Integrin

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; FIBRONECTIN; FOCAL ADHESION KINASE; INTEGRIN; POLYLYSINE; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANOIKIS; APOPTOSIS; ARTICLE; CELL ADHESION; CELL TYPE; CONTROLLED STUDY; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARCINOMA; CASPASE 3; CASPASES; CELL ADHESION; CELL LINE; CELL SIZE; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; GENES, REPORTER; HUMANS; INTEGRINS; MICE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0037078325     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200204050     Document Type: Article

References (45)

1. 2-terminal kinase. J. Cell Biol. 149:741-754.
2. Bodary, S.C., J.W. McLean. 1990. The integrin β1 subunit associates with the vitronectin receptor αv subunit to form a novel vitronectin receptor in a human embryonic kidney cell line. J. Biol. Chem. 265:5938-5941.
3. Chan, P.Y., S.B. Kanner, G. Whitney, and A. Aruffo. 1994. A transmembraneanchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK. J. Biol. Chem. 269:20567-20574.
4. Cohen, O., and A. Kimchi. 2001. DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer. Cell Death Differ. 8:6-15.
5. 2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. EMBO J 16:998-1008.
6. Cohen, O., B. Inbal, J.L. Kissil, T. Raveh, H. Berissi, T. Spivak-Kroizaman, E. Feinstein, and A. Kimchi. 1999. DAP-kinase participates in TNF-α- and Fas-induced apoptosis and its function requires the death domain. J. Cell Biol. 146:141-148.
7. Deiss, L.P., E. Feinstein, H. Berissi, O. Cohen, and A. Kimchi. 1995. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the γ interferon-induced cell death. Genes Dev. 9:15-30.
8. Frisch, S.M., and E. Ruoslahti. 1997. Integrins and anoikis. Curr. Opin. Cell Biol. 9:701-706.
9. Frisch, S.M., and R.A. Screaton. 2001. Anoikis mechanisms. Curr. Opin. Cell Biol. 13:555-562.
10. Frisch, S.M., K. Vuori, E. Ruoslahti, and P.Y. Chan-Hui. 1996. Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol. 134:793-799.
11. Gailit, J., and E. Ruoslahti. 1988. Regulation of the fibronectin receptor affinity by divalent cations. J. Biol. Chem. 263:12927-12932.
12. Giancotti, F.G., and E. Ruoslahti. 1999. Integrin signaling. Science. 285:1028-1032.
13. Ginsberg, M.H., X. Du, and E.F. Plow. 1992. Inside-out integrin signaling. Curr. Opin. Cell Biol. 4:766-771.
14. Hughes, P.E., and M. Pfaff. 1998. Integrin affinity modulation. Trends Cell Biol. 8:359-364.
15. Hungerford, J.E., M.T. Compton, M.L. Matter, B.G. Hoffstrom, and C.A. Otey. 1996. Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. J. Cell Biol. 135:1383-1390.
16. Ilic, D., C.H. Damsky, and T. Yamamoto. 1997. Focal adhesion kinase: at the crossroads of signal transduction. J. Cell Sci. 110:401-407.
17. Ilic, D., E.A. Almeida, D.D. Schlaepfer, P. Dazin, S. Aizawa, and C.H. Damsky. 1998. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J. Cell Biol. 143:547-560.
18. Inbal, B., O. Cohen, S. Polak-Charcon, J. Kopolovic, E. Vadai, L. Eisenbach, and A. Kimchi. 1997. DAP kinase links the control of apoptosis to metastasis. Nature. 390:180-184.
19. Inbal, B., G. Shani, O. Cohen, J.L. Kissil, and A. Kimchi. 2000. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. Mol. Cell. Biol. 20:1044-1054.
20. Inbal, B., S. Bialik, I. Sabanay, G. Shani, and A. Kimchi. 2002. DAP kinase and DRP-1 mediated membrane blebbing and the formation of autophagic vesicles during programmed cell death. J. Cell Biol. 157:455-468.
21. Jang, C.W., C.H. Chen, C.C. Chen, J.Y. Chen, Y.H. Su, and R.H. Chen. 2002. TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase. Nat. Cell Biol. 4:51-58.
22. Jost, M., T.M. Huggett, C. Kari, and U. Rodeck. 2001. Matrix- independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway. Mol. Biol. Cell. 12:1519-1527.
23. Kawai, T., M. Matsumoto, K. Takeda, H. Sanjo, and S. Akira. 1998. ZIP kinase, a novel serine/threonine kinase that mediates apoptosis. Mol. Cell. Biol. 18:1642-1651.
24. Li, G., R. Fridman, and H.R. Kim. 1999. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. Cancer Res. 59:6267-6275.
25. Marti, A., Z. Luo, C. Cunningham, Y. Ohta, J. Hartwig, T.P. Stossel, J.M. Kyriakis, and J. Avruch. 1997. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-α activation of SAPK in melanoma cells. J. Biol. Chem. 272:2620-2628.
26. 2+. J. Biol. Chem. 270:26270-26277.
27. 2-terminal regulatory site on the β1 integrin chain. J. Biol. Chem. 273:7981-7987.
28. O'Toole, T.E., Y. Katagiri, R.J. Faull, K. Peter, R. Tamura, V. Quarama, J.C. Loftus, S.J. Shattil, and M.H. Ginsberg. 1994. Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol. 124:1047-1059.
29. Otto, I.M., T. Raabe, U.E. Rennefahrt, P. Bork, U.R. Rapp, and E. Kerkhoff. 2000. The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization. Curr. Biol. 10:345-348.
30. Pelled, D., T. Raveh, C. Riebeling, M. Fridkin, H. Berissi, A.H. Futerman, and A. Kimchi. 2002. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J. Biol. Chem. 277:1957-1961.
31. Puthalakath, H., D.C. Huang, L.A. O'Reilly, S.M. King, and A. Strasser. 1999. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol. Cell. 3:287-296.
32. Puthalakath, H., A. Villunger, L.A. O'Reilly, J.G. Beaumont, L. Coultas, R.E. Cheney, D.C. Huang, and A. Strasser. 2001. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 293:1829-1832.
33. Raveh, T., and A. Kimchi. 2001. DAP kinase: a proapoptotic gene that functions as a tumor suppressor. Exp. Cell Res. 264:185-192.
34. Raveh, T., G. Droguett, M.S. Horwitz, R.A. DePinho, and A. Kimchi. 2001. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat. Cell Biol. 3:1-7.
35. Sanjo, H., T. Kawai, and S. Akira. 1998. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J. Biol. Chem. 273:29066-29071.
36. Schoenwaelder, S.M., and K. Burridge. 1999. Bidirectional signaling between the cytoskeleton and integrins. Curr. Opin. Cell Biol. 11:274-286.
37. Takagi, J., H.P. Erickson, and T.A. Springer. 2001. C-terminal opening mimics 'inside-out' activation of integrin α5β1. Nat. Struct. Biol. 8:412-416.
38. Tsai, Y.T., Y.H. Su, S.S. Fang, T.N. Huang, Y. Qiu, Y.S. Jou, H.M. Shih, H.J. Kung, and R.H. Chen. 2000. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol. Cell. Biol. 20:2043-2054.
39. Turner, C.E. 2000. Paxillin interactions. J. Cell Sci. 113(Pt. 23):4139-4140.
40. Valentinis, B., K. Reiss, and R. Baserga. 1998. Insulin-like growth factor-1-mediated survival from anoikis: role of cell aggregation and focal adhesion kinase. J. Cell. Physiol. 176:648-657.
41. van de Wiel-van Kemenade, E., Y. van Kooyk, A.J. de Boer, R.J. Huijbens, P. Weder, W. van de Kasteele, C.J. Melief, and C.G. Figdor. 1992. Adhesion of T and B lymphocytes to extracellular matrix and endothelial cells can be regulated through the β subunit of VLA. J. Cell Biol. 117:461-470.
42. van Kooyk, Y., and C.G. Figdor. 2000. Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr. Opin. Cell Biol. 12:542-547.
43. Vinogradova, O., T. Haas, E.F. Plow, and J. Qin. 2000. A structural basis for integrin activation by the cytoplasmic tail of the α IIb-subunit. Proc. Natl. Acad. Sci. USA. 97:1450-1455.
44. Xu, L.H., X. Yang, C.A. Bradham, D.A. Brenner, A.S. Baldwin, Jr., R.J. Craven, and W.G. Cance. 2000. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J. Biol. Chem. 275:30597-30604.
45. Yamamoto, M., T. Hioki, T. Ishii, S. Nakajima-Iijima, and S. Uchino. 2002. DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells. Eur. J. Biochem. 269:139-147.