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Volumn 6, Issue 3, 2004, Pages 200-207

Intercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

EID: 4344659610     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1215/S1152851703000565     Document Type: Article
Times cited : (25)

References (29)
  • 1
    • 0037124164 scopus 로고    scopus 로고
    • Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hyper-methylation in gastric cancers
    • Bae, S.I., Lee, H.S., Kim, S.H., and Kim, W.H. (2002) Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hyper-methylation in gastric cancers. Br. J. Cancer 86, 1888-1892.
    • (2002) Br. J. Cancer , vol.86 , pp. 1888-1892
    • Bae, S.I.1    Lee, H.S.2    Kim, S.H.3    Kim, W.H.4
  • 3
    • 0034742479 scopus 로고    scopus 로고
    • O6-Methylguanine-DNA methyltransferase in pediatric primary brain tumors: Relation to patient and tumor characteristics
    • Bobola, M.S., Berger, M.S., Ellenbogen, R.G., Roberts, T.S., Geyer, J.R., and Silber, J.R. (2001) O6-Methylguanine-DNA methyltransferase in pediatric primary brain tumors: Relation to patient and tumor characteristics. Clin. Cancer Res. 7, 613-619.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 613-619
    • Bobola, M.S.1    Berger, M.S.2    Ellenbogen, R.G.3    Roberts, T.S.4    Geyer, J.R.5    Silber, J.R.6
  • 4
    • 0028227862 scopus 로고
    • Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells
    • Costello, J.F., Futscher, B.W., Tano, K., Graunke, D.M., and Pieper, R.O. (1994) Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J. Biol. Chem. 269, 17228-17237.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17228-17237
    • Costello, J.F.1    Futscher, B.W.2    Tano, K.3    Graunke, D.M.4    Pieper, R.O.5
  • 5
    • 0032969159 scopus 로고    scopus 로고
    • Methylation of selected CpGs in the human O6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing
    • Danam, R.P., Qian, X.C., Howell, S.R., and Brent, TP. (1999) Methylation of selected CpGs in the human O6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing. Mol. Carcinog. 24, 85-89.
    • (1999) Mol. Carcinog. , vol.24 , pp. 85-89
    • Danam, R.P.1    Qian, X.C.2    Howell, S.R.3    Brent, T.P.4
  • 6
    • 0032892070 scopus 로고    scopus 로고
    • Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: Identification of a missense variation in the active site region
    • Deng, C.J., Xie, D.W., Capasso, H., Zhao, Y.J., Wang, L.D., and Hong, J.Y. (1999) Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: Identification of a missense variation in the active site region. Pharmacogenetics 9, 81-87.
    • (1999) Pharmacogenetics , vol.9 , pp. 81-87
    • Deng, C.J.1    Xie, D.W.2    Capasso, H.3    Zhao, Y.J.4    Wang, L.D.5    Hong, J.Y.6
  • 7
    • 0032922238 scopus 로고    scopus 로고
    • Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E. coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine
    • Edara, S., Kanugula, S., and Pegg, A.E. (1999) Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E. coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis 20, 103-108.
    • (1999) Carcinogenesis , vol.20 , pp. 103-108
    • Edara, S.1    Kanugula, S.2    Pegg, A.E.3
  • 8
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • Esteller, M., Hamilton, S.R., Burger, P.C., Baylin, S.B., and Herman, J.G. (1999) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res, 59, 793-797.
    • (1999) Cancer Res, , vol.59 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 10
    • 19244370208 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
    • Esteller, M., Toyota, M., Sanchez-Cespedes, M., Capella, G., Peinado, M.A., Watkins, D.N., Issa, J.P., Sidransky, D., Baylin, S,B., and Herman, J.G. (2000b) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res. 60, 2368-2371.
    • (2000) Cancer Res. , vol.60 , pp. 2368-2371
    • Esteller, M.1    Toyota, M.2    Sanchez-Cespedes, M.3    Capella, G.4    Peinado, M.A.5    Watkins, D.N.6    Issa, J.P.7    Sidransky, D.8    Baylin, S.B.9    Herman, J.G.10
  • 11
    • 0025572753 scopus 로고
    • Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells
    • Fornace, A.J., Jr., Papathanasiou, M.A., Hollander, M.C., and Yarosh, D.B. (1990) Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells. Cancer Res. 50, 7908-7911.
    • (1990) Cancer Res. , vol.50 , pp. 7908-7911
    • Fornace Jr., A.J.1    Papathanasiou, M.A.2    Hollander, M.C.3    Yarosh, D.B.4
  • 14
    • 0032969319 scopus 로고    scopus 로고
    • A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers
    • Herfarth, K.K., Brent, T.P., Danam, R.P., Remack, J.S., Kodner, I.J., Wells, S.A., Jr., and Goodfellow, P.J. (1999) A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers. Mol. Carcinog. 24, 90-98.
    • (1999) Mol. Carcinog. , vol.24 , pp. 90-98
    • Herfarth, K.K.1    Brent, T.P.2    Danam, R.P.3    Remack, J.S.4    Kodner, I.J.5    Wells Jr., S.A.6    Goodfellow, P.J.7
  • 16
    • 0031292579 scopus 로고    scopus 로고
    • O6-Methylguanine-DNA methyltransferase protein levels in pediatric brain tumors
    • Hongeng, S., Brent, T.P., Sanford, R.A., Li, H., Kun, L.E., and Heideman, R.L. (1997) O6-Methylguanine-DNA methyltransferase protein levels in pediatric brain tumors. Clin. Cancer Res. 3, 2459-2463.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 2459-2463
    • Hongeng, S.1    Brent, T.P.2    Sanford, R.A.3    Li, H.4    Kun, L.E.5    Heideman, R.L.6
  • 17
    • 0031595389 scopus 로고    scopus 로고
    • Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bischloroethylnitrosourea: A Southwest Oncology Group study
    • Jaeckle, K.A., Eyre, H.J., Townsend, J.J., Schulman, S., Knudson, H.M., Belanich, M., Yarosh, D.B., Bearman, S.I., Giroux, D.J., and Schold, S.C. (1998) Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bischloroethylnitrosourea: A Southwest Oncology Group study. J. Clin. Oncol. 16, 3310-3315.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3310-3315
    • Jaeckle, K.A.1    Eyre, H.J.2    Townsend, J.J.3    Schulman, S.4    Knudson, H.M.5    Belanich, M.6    Yarosh, D.B.7    Bearman, S.I.8    Giroux, D.J.9    Schold, S.C.10
  • 18
    • 0029030486 scopus 로고
    • Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine
    • Kanugula, S., Goodtzova, K., Edara, S., and Pegg, A.E. (1995) Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine. Biochemistry 34, 7113-7119.
    • (1995) Biochemistry , vol.34 , pp. 7113-7119
    • Kanugula, S.1    Goodtzova, K.2    Edara, S.3    Pegg, A.E.4
  • 19
    • 4344579535 scopus 로고    scopus 로고
    • NIH. National Institutes of Health National Center for Biotechnology Information (available at)
    • NIH. National Institutes of Health (2003) GenBank. National Center for Biotechnology Information (available at http://www.ncbi.nlm.nih.gov/Genbank).
    • (2003) GenBank
  • 20
  • 21
    • 0024522284 scopus 로고
    • A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results
    • Packer, R.J., Sutton, L.N., Atkins, T.E., Radcliffe, J., Bunin, G.R., D'Angio, G., Siegel, K.R., and Schut, L. (1989) A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J. Neurosurg. 70, 707-713.
    • (1989) J. Neurosurg. , vol.70 , pp. 707-713
    • Packer, R.J.1    Sutton, L.N.2    Atkins, T.E.3    Radcliffe, J.4    Bunin, G.R.5    D'Angio, G.6    Siegel, K.R.7    Schut, L.8
  • 23
    • 0033178297 scopus 로고    scopus 로고
    • Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts
    • Pieper, R.O., Lester, K.A., and Fanton, C.P. (1999) Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts. Nucleic Acids Res. 27, 3229-3235.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 3229-3235
    • Pieper, R.O.1    Lester, K.A.2    Fanton, C.P.3
  • 24
    • 0030823671 scopus 로고    scopus 로고
    • Methylation hot spots in the 5′ flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene
    • Qian, X.C., and Brent, T.P. (1997) Methylation hot spots in the 5′ flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene. Cancer Res. 57, 3672-3677.
    • (1997) Cancer Res. , vol.57 , pp. 3672-3677
    • Qian, X.C.1    Brent, T.P.2
  • 25
    • 0027336954 scopus 로고
    • Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain
    • Silber, J.R., Mueller, B.A., Ewers, T.G., and Berger, M.S. (1993) Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain. Cancer Res. 53, 3416-3420.
    • (1993) Cancer Res. , vol.53 , pp. 3416-3420
    • Silber, J.R.1    Mueller, B.A.2    Ewers, T.G.3    Berger, M.S.4
  • 26
    • 0032008537 scopus 로고    scopus 로고
    • O6-methylguanine-DNA methyltransferase activity in adult gliomas: Relation to patient and tumor characteristics
    • Silber, J.R., Bobola, M.S., Ghatan, S., Blank, A., Kolstoe, D.D., and Berger, M.S. (1998) O6-methylguanine-DNA methyltransferase activity in adult gliomas: Relation to patient and tumor characteristics. Cancer Res. 58, 1068-1073.
    • (1998) Cancer Res. , vol.58 , pp. 1068-1073
    • Silber, J.R.1    Bobola, M.S.2    Ghatan, S.3    Blank, A.4    Kolstoe, D.D.5    Berger, M.S.6
  • 27
    • 0034901404 scopus 로고    scopus 로고
    • Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents
    • Srivenugopal, K.S., Shou, J., Mullapudi, S.R., Lang, F.F., Jr., Rao, J.S., and Ali-Osman, F. (2001) Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. Clin. Cancer Res. 7, 1398-1409.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1398-1409
    • Srivenugopal, K.S.1    Shou, J.2    Mullapudi, S.R.3    Lang Jr., F.F.4    Rao, J.S.5    Ali-Osman, F.6
  • 28
    • 0030874380 scopus 로고    scopus 로고
    • Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
    • Watts, G.S., Pieper, R.O., Costello, J.F., Peng, Y.M., Dalton, W.S., and Futscher, B.W. (1997) Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol. Cell Biol. 17, 5612-5619.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 5612-5619
    • Watts, G.S.1    Pieper, R.O.2    Costello, J.F.3    Peng, Y.M.4    Dalton, W.S.5    Futscher, B.W.6
  • 29
    • 0141534395 scopus 로고    scopus 로고
    • A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas
    • Yuan, Q., Matsumoto, K., Nakabeppu, Y, and lwaki, T (2003) A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas. Neuropathology 23, 203-209.
    • (2003) Neuropathology , vol.23 , pp. 203-209
    • Yuan, Q.1    Matsumoto, K.2    Nakabeppu, Y.3    Iwaki, T.4


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