Prevention of diabetes in nonobese diabetic mice mediated by CD1d-restricted nonclassical NKT cells

Journal of Immunology

Volumn 173, Issue 5, 2004, Pages 3112-3118

  Duarte, Nadia ^a,b   Stenström, Martin ^c   Campino, Susana ^a,b   Bergman, Marie Louise ^a,b   Lundholm, Marie ^a   Holmberg, Dan ^a,b,d   Cardell, Susanna L ^c  

^a UMEÅ UNIVERSITY   (Sweden)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^c LUND UNIVERSITY   (Sweden)

^d UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE; LYSOZYME; PEPTIDE; PICORNAVIRUS LIKE 2A PEPTIDE; RETROVIRUS VECTOR; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACKCROSSING; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; EXPERIMENTAL MOUSE; FEMALE; GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MEMORY CELL; NONHUMAN; NONOBESE DIABETIC MOUSE; PATHOGENESIS; PHENOTYPE; PICORNAVIRUS; PRIORITY JOURNAL; SCID MOUSE; STEM CELL GENE THERAPY; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 4344605002     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.5.3112     Document Type: Article

References (39)

1. Makino, S., K. Kunimoto, Y. Muraoka, Y. Mizushima, K. Katagiri, and Y. Tochino. 1980. Breeding of a nonobese, diabetic strain of mice. Jikken Dobutsu. 29:1.
2. Atkinson, M. A., and E. H. Leiter. 1999. The NOD mouse model of type 1 diabetes: as good as it gets? Nat. Med. 5:601.
3. Delovitch, T. L., and B. Singh. 1997. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7:727.
4. Boitard, C., R. Yasunami, M. Dardenne, and J. F. Bach. 1989. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J. Exp. Med. 169:1669.
5. Hutchings, P. R., and A. Cooke. 1990. The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young males. J. Autoimmun. 3:175.
6. Harrison, L. C., M. Dempsey-Collier, D. R. Kramer, and K. Takahashi. 1996. Aerosol insulin induces regulatory CD8γδ T cells that prevent murine insulin-dependent diabetes. J. Exp. Med. 184:2167.
7. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
8. + thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse. J. Immunol. 161:2620.
9. + T cells that prevent diabetes onset in nonobese diabetic mice. J. Immunol. 164:240.
10. Sharif, S., G. A. Arreaza, P. Zucker, Q. S. Mi, and T. L. Delovitch. 2002. Regulation of autoimmune disease by natural killer T cells. J. Mol. Med. 80:290.
11. Porcelli, S. A., and R. L. Modlin. 1999. The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu. Rev. Immunol. 17:297.
12. Bendelac, A., M. N. Rivera, S. H. Park, and J. H. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15:535.
13. +-like thymocytes in the NOD mouse. Eur. J. Immunol. 26:2989.
14. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187:1047.
15. Wilson, S. B., S. C. Kent, K. T. Patton, T. Orban, R. A. Jackson, M. Exley, S. Porcelli, D. A. Schatz, M. A. Atkinson, S. P. Balk, et al. 1998. Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature 391:177.
16. Kukreja, A., G. Cost, J. Marker, C. Zhang, Z. Sun, K. Lin-Su, S. Ten, M. Sanz, M. Exley, B. Wilson, et al. 2002. Multiple immuno-regulatory defects in type-1 diabetes. J. Clin. Invest. 109:131.
17. Shi, F. D., M. Flodstrom, B. Balasa, S. H. Kim, K. Van Gunst, J. L. Strominger, S. B. Wilson, and N. Sarvetnick. 2001. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc. Natl. Acad. Sci. USA 98:6777.
18. Naumov, Y. N., K. S. Bahjat, R. Gausling, R. Abraham, M. A. Exley, Y. Koezuka, S. B. Balk, J. L. Strominger, M. Clare-Salzer, and S. B. Wilson. 2001. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc. Natl. Acad. Sci. USA 98:13838.
19. Wang, B., Y. B. Geng, and C. R. Wang. 2001. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194:313.
20. + T lymphocytes. Science 268:863.
21. + T cells in major histocompatibility complex class II-deficient mice. J. Exp. Med. 182:993.
22. Zeng, D., M. Dick, L. Cheng, M. Amano, S. Dejbakhsh-Jones, P. Huie, R. Sibley, and S. Strober. 1998. Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines. J. Exp. Med. 187:525.
23. Behar, S. M., T. A. Podrebarac, C. J. Roy, C. R. Wang, and M. B. Brenner. 1999. Diverse TCRs recognize murine CD1. J. Immunol. 162:161.
24. + T cell subsets distinguished by function and T cell receptor type. Eur. J. Immunol. 34:56.
25. Lehuen, A., O. Lantz, L. Beaudoin, V. Laloux, C. Carnaud, A. Bendelac, J. F. Bach, and R. C. Monteiro. 1998. Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188:1831.
26. Laloux, V., L. Beaudoin, D. Jeske, C. Carnaud, and A. Lehuen. 2001. NK T cell-induced protection against diabetes in Vα14-Jα281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen. J. Immunol. 166:3749.
27. Beaudoin, L., V. Laloux, J. Novak, B. Lucas, and A. Lehuen. 2002. NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic β cells. Immunity 17:725.
28. + T cells with a transgenic variant TCR. J. Immunol. 165:168.
29. Matsuda, J. L., O. V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C. R. Wang, Y. Koezuka, and M. Kronenberg. 2000. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192:741.
30. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD1d-restricted and TCR-mediated activation of vα14 NKT cells by glycosylceramides. Science 278:1626.
31. Wilson, S. B., S. C. Kent, H. F. Horton, A. A. Hill, P. L. Bollyky, D. A. Hafler, J. L. Strominger, and M. C. Byrne. 2000. Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type 1 diabetes. Proc. Natl. Acad. Sci. USA 97:7411.
32. Hong, S., M. T. Wilson, I. Serizawa, L. Wu, N. Singh, O. V. Naidenko, T. Miura, T. Haba, D. C. Scherer, J. Wei, et al. 2001. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7:1052.
33. + T-cells observed in type 1 diabetes. Diabetes Care 25:1818.
34. Lee, P. T., A. Putnam, K. Benlagha, L. Teyton, P. A. Gottlieb, and A. Bendelac. 2002. Testing the NKT cell hypothesis of human IDDM pathogenesis. J. Clin. Invest. 110:793.
35. Bendelac, A., R. D. Hunziker, and O. Lantz. 1996. Increased interleukin 4 and immumoglobulin E production in transgenic mice overexpressing NK1 T cells. J. Exp. Med. 184:1285.
36. + T cells in autoimmune diabetes. Nat. Immunol. 2:1117.
37. + T cells. J. Immunol. 166:4209.
38. Sharif, S., G. A. Arreaza, P. Zucker, Q. S. Mi, J. Sondhi, O. V. Naidenko, M. Kronenberg, Y. Koezuka, T. L. Delovitch, J. M. Gombert, et al. 2001. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes. Nat. Med. 7:1057.
39. Falcone, M., B. Yeung, L. Tucker, E. Rodriguez, and N. Sarvetnick. 1999. A defect in interleukin 12-induced activation and interferon γ secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-dependent diabetes mellitus. J. Exp. Med. 190:963.