Polymorphisms of methionine metabolism and susceptibility to meningioma formation: Laboratory investigation

Journal of Neurosurgery

Volumn 108, Issue 5, 2008, Pages 999-1004

  Semmler, Alexander ^a   Simon, Matthias ^a   Moskau, Susanna ^a   Linnebank, Michael ^a,b  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

CpG island; DNA methylation; Meningioma; Methionine; Polymorphism

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYSTATHIONINE BETA SYNTHASE; DIHYDROFOLATE REDUCTASE; METHIONINE; REDUCED FOLATE CARRIER; TRANSCOBALAMIN;

ADULT; AGED; ALLELE; AMINO ACID METABOLISM; ARTICLE; CANCER SURGERY; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CASE CONTROL STUDY; CAUCASIAN; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRACRANIAL TUMOR; MAJOR CLINICAL STUDY; MALE; MENINGIOMA; PRIORITY JOURNAL; WILD TYPE;

BRAIN NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MENINGIOMA; METHIONINE; MIDDLE AGED; POLYMORPHISM, GENETIC; VARIATION (GENETICS);

EID: 43249115982     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/JNS/2008/108/5/0999     Document Type: Article

References (45)

1. Afman LA, Lievers KJ, van der Put NM, Trijbels FJ, Blom HJ: Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects. Eur J Hum Genet 10:433-438, 2002
2. Beetstra S, Thomas P, Salisbury C, Turner J, Fenech M: Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei. Mutat Res 578:317-326, 2005
3. Bello MJ, Amiñoso C, Lopez-Marin I, Arjona D, Gonzalez-Gomez P, Alonso ME, et al: DNA methylation of multiple promoter-associated CpG islands in meningiomas: relationship with the allelic status at 1p and 22q. Acta Neuropathol 108:413-421, 2004
4. Bird A: DNA methylation patterns and epigenetic memory. Genes Dev 16:6-21, 2002
5. Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, et al: S-Adenosylmethionine and methylation. FASEB J 10:471-480, 1996
6. Choi SW, Mason JB: Folate and carcinogenesis: an integrated scheme. J Nutr 130:129-132, 2000
7. Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, et al: Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 297:2351-2359, 2007
8. Detich N, Hamm S, Just G, Knox JD, Szyf M: The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. J Biol Chem 278:20812-20820, 2003
9. Garcea R, Daino L, Pascale R, Simile MM, Puddu M, Ruggiu ME, et al: Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine: S-adenosylhomocysteine ratio. Carcinogenesis 10:1183-1192, 1989
10. Ge Y, Jensen T, James SJ, Becton DL, Massey GV, Weinstein HJ, et al: High frequency of the 844ins68 cystathionine-beta-synthase gene variant in Down syndrome children with acute myeloid leukemia. Leukemia 16:2339-2341, 2002
11. Gellekink H, den Heijer M, Heil SG, Blom HJ: Genetic determinants of plasma total homocysteine. Semin Vasc Med 5:98-109, 2005
12. Gemmati D, Ongaro A, Scapoli GL, Della PM, Tognazzo S, Serino ML, et al: Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev 13:787-794, 2004
13. Hartmann C, Bostrom J, Simon M: Diagnostic and molecular pathology of meningiomas. Expert Rev Neurother 6:1671-1683, 2006
14. Henao OL, Piyathilake CJ, Waterbor JW, Funkhouser E, Johanning GL, Heimburger DC, et al: Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3. Int J Cancer 113:991-997, 2005
15. Herman JG: Hypermethylation of tumor suppressor genes in cancer. Semin Cancer Biol 9:359-367, 1999
16. Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:2042-2054, 2003
17. Jang H, Mason JB, Choi SW: Genetic and epigenetic interactions between folate and aging in carcinogenesis. J Nutr 135:2967S-2971S, 2005
18. Janosikova B, Pavlikova M, Kocmanova D, Vitova A, Vesela K, Krupkova L, et al: Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease. Mol Genet Metab 79:167-175, 2003
19. Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 3:415-428, 2002
20. Kim YI: Does a high folate intake increase the risk of breast cancer? Nutr Rev 64:468-475, 2006
21. Kim YI: Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr 135:2703-2709, 2005
22. Lincz LF, Scorgie FE, Kerridge I, Potts R, Spencer A, Enno A: Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma. Br J Haematol 120:1051-1054, 2003
23. Linnebank M, Fliessbach K, Kolsch H, Rietschel M, Wullner U: The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity. Int J Mol Med 16:759-761, 2005
24. Linnebank M, Moskau S, Farmand S, Fliessbach K, Kölsch H, Bös M, et al: Homocysteine and carotid intima-media rhickness in a German population: lack of clinical relevance. Stroke 37:2840-2842, 2006
25. Linnebank M, Schmidt S, Kolsch H, Linnebank A, Heun R, Schmidt-Wolf IG, et al: The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma. Br J Cancer 90:1969-1971, 2004
26. Lissowska J, Gaudet MM, Brinton LA, Chanock SJ, Peplonska B, Welch R, et al: Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses. Int J Cancer 120:2696-2703, 2007
27. Liu Y, Pang JC, Dong S, Mao B, Poon WS, Ng HK: Aberrant CpG island hypermethylation profile is associated with atypical and anaplastic meningiomas. Hum Pathol 36:416-425, 2005
28. Ma J, Stampfer MJ, Christensen B, Giovannucci E, Hunter DJ, Chen J, et al: A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 8:825-829, 1999
29. Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, et al: A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 16:1325-1329, 2007
30. McCarthy BJ, Davis FG, Freels S, Surawicz TS, Damek DM, Grutsch J, et al: Factors associated with survival in patients with meningioma. J Neurosurg 88:831-839, 1998
31. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, et al: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1:686-692, 1995
32. Mudd SH, Levy HL, Kraus JP: Disorders of transsulfuration, in Scriver CR, Beaudet AL, Sly WS, et al (eds): The Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill, 2001, pp 2007-2056
33. Paz MF, Avila S, Fraga MF, Pollan M, Capella G, Peinado MA, et al: Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res 62:4519-4524, 2002
34. Perry A, Gutmann DH, Reifenberger G: Molecular pathogenesis of meningiomas. J Neurooncol 70:183-202, 2004
35. Sadetzki S, Chetrit A, Freedman L, Stovall M, Modan B, Novikov I: Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis. Radiat Res 163:424-432, 2005
36. Semmler A, Simon M, Moskau S, Linnebank M: The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev 15:2314-2316, 2006
37. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, et al: Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci U S A 96:12810-12815, 1999
38. Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG: Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990-1994. Neuro-oncol 1:14-25, 1999
39. Tsai MY, Yang F, Bignell M, Aras O, Hanson NQ: Relation between plasma homocysteine concentration, the 844ins68 variant of the cystathionine beta-synthase gene, and pyridoxal-5′-phosphate concentration. Mol Genet Metab 67:352-356, 1999
40. Ulrey CL, Liu L, Andrews LG, Tollefsbol TO: The impact of metabolism on DNA methylation. Hum Mol Genet 14 (Spec No. 1):R139-R147, 2005
41. Ulrich CM, Curtin K, Potter JD, Bigler J, Caan B, Slattery ML: Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 14:2509-2516, 2005
42. Ulvik A, Vollset SE, Hansen S, Gislefoss R, Jellum E, Ueland PM: Colorectal cancer and the methylenetetrahydrofolate reductase 677C→T and methionine synthase 2756A→G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort. Cancer Epidemiol Biomarkers Prev 13:2175-2180, 2004
43. Wang XL, Duarte N, Cai H, Adachi T, Sim AS, Cranney G, et al: Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. Atherosclerosis 146:133-140, 1999
44. Whittle IR, Smith C, Navoo P, Collie D: Meningiomas. Lancet 363:1535-1543, 2004
45. Winkelmayer WC, Eberle C, Sunder-Plassmann G, Fodinger M: Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients. Kidney Int 63:2280-2285, 2003