Interdomain interaction reconstitutes the functionality of PknA, a eukaryotic type Ser/Thr kinase from Mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 283, Issue 12, 2008, Pages 8023-8033

  Thakur, Meghna ^a   Chaba, Rachna ^a,b   Mondal, Alok K ^a   Chakraborti, Pradip K ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; CELL MEMBRANES; CELL PROLIFERATION; ELECTRIC FIELD EFFECTS; ESCHERICHIA COLI; PHOSPHORYLATION; PORT TERMINALS;

BIOINFORMATIC ANALYSES; CATALYTIC CORES; CATALYTIC DOMAINS; CELL DIVISIONS; CELL ELONGATIONS; CELLULAR FUNCTIONS; DELETION MUTANTS; DIFFERENT DOMAINS; E. COLI; ENZYMATIC ACTIVITIES; EXTRACELLULAR DOMAINS; FUNCTIONAL PROTEINS; IN CELLS; IN-VIVO; INTERDOMAIN INTERACTIONS; JUXTAMEMBRANE; KINASE DOMAINS; MORPHOLOGICAL CHANGES; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORYLATION ACTIVITIES; PROTEIN KINASES; TERMINAL REGIONS; TRANSMEMBRANE;

CHEMICAL REACTIONS;

BACTERIAL ENZYME; PROTEIN SERINE THREONINE KINASE; BACTERIAL PROTEIN; MEMBRANE PROTEIN; PKNA PROTEIN, MYCOBACTERIUM TUBERCULOSIS;

ARTICLE; AUTOPHOSPHORYLATION; CELL ELONGATION; DELETION MUTANT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; IN VIVO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; EUKARYOTIC CELL; GENE DELETION; GENETICS; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SEQUENCE ANALYSIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; MYCOBACTERIUM TUBERCULOSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; ESCHERICHIA COLI; EUKARYOTIC CELLS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE DELETION;

EID: 43149116352     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707535200     Document Type: Article

References (45)

1. Hunter, T. (2000) Cell 100, 113-127
2. West, A. H., and Stock, A. M. (2001) Trends Biochem. Sci. 26, 369-376
3. Ginsberg, A. M., and Spigelman, M. (2007) Nat. Med. 13, 290-294
4. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., III, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M. A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., and Barrell, B. G. (1998) Nature 393, 537-544
5. Av-Gay, Y., and Everett, M. (2000) Trends Microbiol. 8, 238-244
6. Greenstein, A. E., Grundner, C., Echols, N., Gay, L. M., Lombana, T. N., Miecskowski, C. A., Pullen, K. E., Sung, P., and Alber, T. (2005) J. Mol. Microbiol. Biotechnol. 9, 167-181
7. McCarty, D. R., and Chory, J. (2000) Cell 103, 201-209
8. Koul, A., Choidas, A. K., Tyagi, A. K., Drlica, K., Singh, Y., and Ulrich, A. (2001) Microbiology 147, 2307-2314
9. Chaba, R., Raje, M., and Chakraborti, P. K. (2002) Eur. J. Biochem. 269, 1078-1085
10. Molle, V., Girard-Blanc, C., Kremer, L., Doublet, P., Cozzone, A. J., and Prost, J. (2003) Biochem. Biophys. Res. Commun. 308, 820-825
11. Molle, V., Kremer, L., Girard-Blanc, C., Besra, G. S., Cozzone, A. J., and Prost, J. F. (2003) Biochemistry 42, 15300-15309
12. Gopalaswamy, R., Narayanan, P. R., and Narayanan, S. (2004) Protein Expression Purif. 36, 82-89
13. Sharma, K., Chandra, H., Gupta, P. K., Pathak, M., Narayan, A., Meena, L. S., D'Souza, R. C., Chopra, P., Ramachandran, S., and Singh, Y. (2004) FEMS Microbiol. Lett. 233, 107-113
14. Walburger, A., Koul, A., Ferrari, G., Nguyen, L., Prescianotto-Baschong, C., Huygen, K., Klebl, B., Thompson, C., Bacher, G., and Pieters, J. (2004) Science 304, 1800-1804
15. Greenstein, A., Echols, E. N., Lombana, T. N., King, D. S., and Alber, T. (2007) J. Biol. Chem. 282, 11427-11435
16. Canova, M. J., Veyron-Churlet, R., Zanella-Cleon, I., Cohen-Gonsaud, M., Cozzone, A. J., Becchi, M., Kremer, L., and Molle, V. (2008) Proteomics 8, 521-533
17. Kang, C. M., Abbott, D. W., Park, S. T., Dascher, C. C., and Cantley, L. C. (2005) Genes Dev. 19, 1692-1704
18. Villarino, A., Duran, R., Wehenkel, A., Fernandez, P., England, P., Brodin, P., Cole, S. T., Zimny-Arndt, U., Jungblut, P. R., Cervenansky, C., and Alzari, P. M. (2005) J. Mol. Biol. 350, 953-963
19. Ortiz-Lombardia, M., Pompeo, F., Boitel, B., and Alzari, P. M. (2003) J. Biol. Chem. 278, 13094-13100
20. Young, T. A., Delagoutte, B., Endrizzi, J. A., Falick, A. M., and Alber, T. (2003) Nat. Struct. Biol. 10, 168-174
21. Thakur, M., and Chakraborti, P. K. (2006) J. Biol. Chem. 281, 40107-40113
22. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
23. Yang, W., Zhang, L., Lu, Z., Tao, W., and Zhai, Z. (2001) Protein Expression Purif. 22, 472-478
24. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., pp. 1.82-1.84, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
25. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
26. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) Nucleic Acids Res. 25, 4876-4882
27. McGuffin, L. J., Bryson, K., and Jones, D. T. (2000) Bioinformatics (Oxf.) 16, 404-405
28. Schwede, T., Koppl, J., Guex, N., and Peitsch, M. C. (2003) Nucleic Acids Res. 31, 3381-3385
29. Sierk, M. L., and Kleywegt, G. J. (2004) Structure (Lond.) 12, 2103-2111
30. DeLano, W. L. (1998) The PyMOL Molecular Graphics System, DeLano Scientific LLC, San Carlos, CA
31. Duran, R., Villarino, A., Bellinzoni, M., Wehenkel, A., Fernandez, P., Boitel, B., Cole, S. T., Alzari, P. M., and Cervenansky, C. (2005) Biochem. Biophys. Res. Commun. 333, 858-867
32. Nolen, B., Tylor, S., and Ghosh, G. (2004) Mol. Cell 15, 661-675
33. Johnson, L. N., Noble, M. E. M., and Owen, D. J. (1996) Cell 85, 149-158
34. Boitel, B., Ortiz-Lombardia, M., Duran, R., Pompeo, F., Cole, S. T., Cervenansky, C., and Alzari, P. M. (2003) Mol. Microbiol. 49, 1493-1508
35. Oliver, A. W., Knapp, S., and Pearl, L. H. (2007) Trends Biochem. Sci. 32, 351-356
36. Ascano, M., and Robbins, D. J. (2004) Mol. Cell. Biol. 24, 10397-10405
37. Deutscher, J., and Saier, M. H. (2005) J. Mol. Microbiol. Biotechnol. 9, 125-131
38. Udo, H., Munoz-Dorado, J., Inouye, M., and Inouye, S. (1995) Genes Dev. 9, 972-983
39. Huse, M., Chen, Y. G., Massague, J., and Kuriyan, J. (1999) Cell 96, 425-436
40. Thiel, K. W., and Carpenter, G. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 19238-19243
41. Park, S. Y., Avraham, H. K., and Avraham, S. (2004) J. Biol. Chem. 279, 33315-33322
42. Rogers, J. A., Read, R. D., Li, J., Peters, K. L., and Smithgall, T. E. (1996) J. Biol. Chem. 271, 17519-17525
43. Lammers, R., Obberghena, E. V., Ballotti, R., Schlessinger, J., and Ullrich, A. (1990) J. Biol. Chem. 265, 16886-16890
44. Cai, S. J., and Inouye, M. (2003) J. Mol. Biol. 329, 495-503
45. Iuchi, S. (1993) J. Biol. Chem. 268, 23972-23980