Allosteric activation by dimerization of the PknD receptor Ser/Thr protein kinase from Mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 282, Issue 15, 2007, Pages 11427-11435

  Greenstein, Andrew E ^a   Echols, Nathaniel ^a   Lombana, T Noelle ^a   King, David S ^a   Alber, Tom ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOACTIVITY; DIMERIZATION; DIMERS; DISEASES; PHOSPHORYLATION;

KINASE DOMAIN (KD); MYCOBACTERIUM TUBERCULOSIS; ORTHOLOGS; PROTEIN KINASE;

ENZYMES;

PROTEIN SERINE KINASE; PKND PROTEIN, NOSTOC SP. PCC 7120; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; DIMERIZATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WILD TYPE; ALLOSTERISM; AMINO ACID SEQUENCE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROTEIN QUATERNARY STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY;

BACTERIA (MICROORGANISMS); EUKARYOTA; MYCOBACTERIUM TUBERCULOSIS; PROKARYOTA;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; CATALYSIS; DIMERIZATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

EID: 85047696182     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610193200     Document Type: Article

References (31)

1. Huse, M., and Kuriyan, J. (2002) Cell 109, 275-282
2. Greenstein, A. E., Grundner, C., Echols, N., Gay, L. M., Lombana, T. N., Miecskowski, C. A., Pullen, K. E., Sung, P. Y., and Alber, T. (2005) J. Mol. Microbiol. Biotechnol. 9, 167-181
3. Gay, L. M., Ng, H. L., and Alber, T. (2006) J. Mol. Biol. 360, 409-420
4. Ortiz-Lombardia, M., Pompeo, F., Boitel, B., and Alzari, P. M. (2003) J. Biol. Chem. 278, 13094-13100
5. Young, T. A., Delagoutte, B., Endrizzi, J. A., Falick, A. M., and Alber, T. (2003) Nat. Struct. Biol. 10, 168-174
6. Good, M. C., Greenstein, A. E., Young, T. A., Ng, H. L., and Alber, T. (2004) J. Mol. Biol. 339, 459-469
7. Dar, A. C., Dever, T. E., and Sicheri, F. (2005) Cell 122, 887-900
8. Dey, M., Cao, C., Dar, A. C., Tamura, T., Ozato, K., Sicheri, F., and Dever, T. E. (2005) Cell 122, 901-913
9. Pruitt, K. D., Tatusova, T., and Maglott, D. R. (2005) Nucleic Acids Res. 33, D501-D504
10. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Nucleic Acids Res. 25, 3389-3402
11. Finn, R. D., Mistry, J., Schuster-Bockler, B., Griffiths-Jones, S., Hollich, V., Lassmann, T., Moxon, S., Marshall, M., Khanna, A., Durbin, R., Eddy, S. R., Sonnhammer, E. L., and Bateman, A. (2006) Nucleic Acids Res. 34, D247-D251
12. Edgar, R. C. (2004) Nucleic Acids Res. 32, 380-385
13. Landau, M., Mayrose, I., Rosenberg, Y., Glaser, F., Martz, E., Pupko, T., and Ben-Tal, N. (2005) Nucleic Acids Res. 33, W299-W302
14. Choi, J., Chen, J., Schreiber, S. L., and Clardy, J. (1996) Science 273, 239-242
15. Pullen, K. E., Ng, H. L., Sung, P. Y., Good, M. C., Smith, S. M., and Alber, T. (2004) Structure (Camb.) 12, 1947-1954
16. Greenstein, A. E., MacGurn, J. A., Baer, C. E., Falick, A. M., Cox, J. S., and Alber, T. (2007) PLoS Pathogens, in press
17. Alderwick, L. J., Molle, V., Kremer, L., Cozzone, A. J., Dafforn, T. R., Besra, G. S., and Futterer, K. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 2558-2563
18. Kang, C. M., Abbott, D. W., Park, S. T., Dascher, C. C., Cantley, L. C., and Husson, R. N. (2005) Genes Dev. 19, 1692-1704
19. Molle, V., Kremer, L., Girard-Blanc, C., Besra, G. S., Cozzone, A. J., and Prost, J. F. (2003) Biochemistry 42, 15300-15309
20. Perez, J., Garcia, R., Bach, H., de Waard, J. H., Jacobs, W. R., Jr., Av-Gay, Y., Bubis, J., and Takiff, H. E. (2006) Biochem. Biophys. Res. Commun. 348, 6-12
21. Sharma, K., Gupta, M., Krupa, A., Srinivasan, N., and Singh, Y. (2006) FEBS J. 273, 2711-2721
22. Villarino, A., Duran, R., Wehenkel, A., Fernandez, P., England, P., Brodin, P., Cole, S. T., Zimny-Arndt, U., Jungblut, P. R., Cervenansky, C., and Alzari, P. M. (2005) J. Mol. Biol. 350, 953-963
23. Duran, R., Villarino, A., Bellinzoni, M., Wehenkel, A., Fernandez, P., Boitel, B., Cole, S. T., Alzari, P. M., and Cervenansky, C. (2005) Biochem. Biophys. Res. Commun. 333, 858-867
24. Boitel, B., Ortiz-Lombardia, M., Duran, R., Pompeo, F., Cole, S. T., Cervenansky, C., and Alzari, P. M. (2003) Mol. Microbiol. 49, 1493-1508
25. Av-Gay, Y., and Everett, M. (2000) Trends Microbiol. 8, 238-244
26. Madec, E., Laszkiewicz, A., Iwanicki, A., Obuchowski, M., and Seror, S. (2002) Mol. Microbiol. 46, 571-586
27. Schlessinger, J. (2000) Cell 103, 211-225
28. Zhang, X., Gureasko, J., Shen, K., Cole, P. A., and Kuriyan, J. (2006) Cell 125, 1137-1149
29. Padyana, A. K., Qiu, H., Roll-Mecak, A., Hinnebusch, A. G., and Burley, S. K. (2005) J. Biol. Chem. 280, 29289-29299
30. Williams, J. C., Weijland, A., Gonfloni, S., Thompson, A., Courtneidge, S. A., Superti-Furga, G., and Wierenga, R. K. (1997) J. Mol. Biol. 274, 757-775
31. Boudeau, J., Miranda-Saavedra, D., Barton, G. J., and Alessi, D. R. (2006) Trends Cell Biol. 16, 443-452