High levels of serum IL-18 promote cartilage loss through suppression of aggrecan synthesis

Bone

Volumn 42, Issue 6, 2008, Pages 1102-1110

  Inoue, Hidetake ^a   Hiraoka, Koji ^a   Hoshino, Tomoaki ^a   Okamoto, Masaki ^a   Iwanaga, Tomoaki ^a   Zenmyo, Michihisa ^a   Shoda, Takanori ^a   Aizawa, Hisamichi ^a   Nagata, Kensei ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aggrecan; Articular cartilage loss; Interleukin 18; Osteoarthritis; Transgenic mouse

Indexed keywords

AGGRECAN; GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; RECOMBINANT INTERLEUKIN 18;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; FEMUR CONDYLE; GENE EXPRESSION; INFLAMMATORY CELL; KNEE; LUNG; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN SYNTHESIS INHIBITION; SYNOVITIS; TIBIA; TRANSGENIC MOUSE; WILD TYPE;

AGE FACTORS; AGGRECANS; ANIMALS; CARTILAGE; CARTILAGE, ARTICULAR; CASPASE 1; CHONDROCYTES; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-18; INTERLEUKIN-1BETA; KNEE JOINT; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOARTHRITIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 43149100555     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.01.031     Document Type: Article

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