Exacerbated and prolonged allergic and non-allergic inflammatory cutaneous reaction in mice with targeted interleukin-18 expression in the skin

Journal of Investigative Dermatology

Volumn 121, Issue 3, 2003, Pages 502-509

  Kawase, Yusuke ^a   Hoshino, Tomoaki ^b   Yokota, Koichi ^a   Kuzuhara, Akemi ^a   Kirii, Yasuyuki ^a   Nishiwaki, Eiji ^a   Maeda, Yu ^a   Takeda, Junji ^c   Okamoto, Masaki ^b   Kato, Seiya ^b   Imaizumi, Toshihiro ^b   Aizawa, Hisamichi ^b   Yoshino, Kohichiro ^a  

^a Nippon Organon K K   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Allergy; Cytokines; Inflammation; Knockout; Skin; Transgenic

Indexed keywords

BENZENE DERIVATIVE; CROTON OIL; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 18; INTERLEUKIN 4; TRICHLORONITROBENZENE; UNCLASSIFIED DRUG;

ACANTHOSIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE EXACERBATION; EOSINOPHILIA; FEMALE; GENE OVEREXPRESSION; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE COUNT; MALE; MAST CELL; MOUSE; NEUTROPHILIA; NONHUMAN; OTITIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SKIN ALLERGY; SKIN INFLAMMATION; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

EID: 0042835808     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12407.x     Document Type: Article

References (33)

1. Carroll JM, Crompton T, Seery JP, Watt FM: Transgenic mice expressing IFN-gamma in the epidermis have eczema, hair hypopigmentation, and hair loss. J Invest Dermatol 108:412-422, 1997
2. Companjen AR, van der Velden VH, Vooys A, Debets R, Benner R, Prens EP: Human keratinocytes are major producers of IL-18: Predominant expression of the unprocessed form. Eur Cytokine New 11:383-390, 2000
3. Dieli F, Sireci G, Scire E, Salerno A, Bellavia A: Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice. Immunology 98:71-79, 1999
4. Dinarello CA: IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 103:11-24, 1999
5. Gerberick GF, Cruse LW, Ryan CA: Local lymph node assay: Differentiating allergic and irritant responses using flow cytometry. Methods 19:48-55, 1999
6. Gocinski BL, Tigelaar RE: Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion. J Immunol 144:4121-4128, 1990
7. Homey B, Dieu-Nosjean MC, Wiesenborn A, et al: Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 164:6621-6632, 2000
8. Hoshino T, Wiltrout RH, Young HA: IL-18 is a potent coinducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response. J Immunol 162:5070-5077, 1999
9. Hoshino T, Yagita H, Ortaldo JR, Wiltrout RH, Young HA: In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and upregulation of CD40 ligand (CD154) expression on CD4+ T cells. Eur J Immunol 30:1998-2006, 2000
10. Hoshino T, Kawase Y, Okamoto M, et al: Cutting edge: IL-18-transgenic mice. In vivo evidence of a broad role for IL-18 in modulating immune function. J Immunol 166:7014-7018, 2001
11. Kitagaki H, Kimishima M, Teraki Y, Hayakawa J, Hayakawa K, Fujisawa S, Shiohara T: Distinct in vivo and in vitro cytokine profiles of draining lymph node cells in acute and chronic phases of contact hypersensitivity: Importance of a type 2 cytokine-rich cutaneous milieu for the development of an early-type response in the chronic phase. J Immunol 163:1265-1273, 1999
12. Kohka H, Nishibori M, Iwagaki H, et al: Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells. J Immunol 164:6640-6646, 2000
13. Konishi H, Tsutsui H, Murakami T, et al: IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Proc Natl Acad Sci USA 99:11340-11345, 2002
14. Leung BP, Culshaw S, Gracie JA, et al: A role for IL-18 in neutrophil activation. J Immunol 167:2879-2886, 2001
15. Mee JB, Alam Y, Groves RW: Human keratinocytes constitutively produce but do not process interleukin-18. Br J Dermatol 143:330-336, 2000
16. Nagai H, Ueda Y, Ochi T, Hirano Y, Tanaka H, Inagaki N, Kawada K: Different role of IL-4 in the onset of hapten-induced contact hypersensitivity in BALB/c and C57BL/6 mice. Br J Pharmacol 129:299-306, 2000
17. Naik SM, Cannon G, Burbach GJ, et al: Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene. J Invest Dermatol 113:766-772, 1999
18. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H: Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 19:423-474, 2001
19. Okamura H, Tsutsi H, Komatsu T, et al: Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378:88-91, 1995
20. Sano S, Itami S, Takeda K, et al: Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J 18:4657-4668, 1999
21. Tanaka T, Tsutsui H, Yoshimoto T, et al: Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga. Int Arch Allergy Immunol 125:236-240, 2001
22. Tepper RI, Levinson DA, Stanger BZ, Campos-Torres J, Abbas AK, Leder P: IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62:457-467, 1990
23. Thomas JA, Allen JL, Tsen M, et al: Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol 163:978-984, 1999
24. Wang B, Feliciani C, Howell BG, Freed I, Cai Q, Watanabe H, Sauder DN: Contribution of Langerhans cell-derived IL-18 to contact hypersensitivity. J Immunol 168:3303-3308, 2002
25. Wang W, Tanaka T, Okamura H, Sugita M, Higa S, Kishimoto T, Suemura M: Interleukin-18 enhances the production of interleukin-8 by eosinophils. Eur J Immunol 31:1010-1016, 2001
26. Wild JS, Sigounas A, Sur N, Siddiqui MS, Alam R, Kurimoto M, Sur S: IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma. J Immunol 164:2701-2710, 2000
27. Xu B, Aoyama K, Yu S, et al: Expression of interleukin-18 in murine contact hypersensitivity. J Interferon Cytokine Res 18:653-659, 1998
28. Xu D, Trajkovic V, Hunter D, et al: IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and generic background. Eur J Immunol 30:3147-3156, 2000
29. Xu H, Dilulio NA, Fairchild RL: T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: Interferon gamma-producing (Tc1) effector CD8+ Tcells and interleukin (II) 4/II-10-producing (Th2) negative regulatory CD4+ T cells. J Exp Med 183:1001-1012, 1996
30. Yamanaka K, Tanaka M, Tsutsui H, et al: Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J Immunol 165:997-1003, 2000
31. Yokozeki H, Ghoreishi M, Takagawa S, et al: Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity. J Exp Med 191:995-1004, 2000
32. Yoshimoto T, Tsutsui H, Tominaga K, et al: IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci USA 96:13962-13966, 1999
33. Yoshimoto T, Mizutani H, Tsutsui H, et al: IL-18 induction of IgE: Dependence on CD4+ T cells, IL-4 and STAT6. Nature Immunol 1:132-137, 2000