Cellular response to accumulation of recombinant proteins in the E. coli inner membrane: Implications for proteolysis and productivity of the secretory expression system

Biochemical Engineering Journal

Volumn 39, Issue 1, 2008, Pages 74-83

  Balagurunathan, Balaji ^a   Jayaraman, Guhan ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

Author keywords

Cellular stress response; Co translocational proteolysis; Escherichia coli; Inner membrane protease; OmpA signal peptide; Secretory expression

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE EXPRESSION; PROTEOLYSIS;

CELLULAR STRESS RESPONSE; CO-TRANSLOCATIONAL PROTEOLYSIS; INNER-MEMBRANE PROTEASE; OMPA SIGNAL PEPTIDE; SECRETORY EXPRESSION;

PROTEINS;

PROTEINASE; RECOMBINANT PROTEIN; STREPTOKINASE;

ARTICLE; CELL MEMBRANE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; UPREGULATION;

ESCHERICHIA COLI;

EID: 43049118976     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2007.08.014     Document Type: Article

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