Human monoclonal antibody AVP-21D9 to protective antigen reduces dissemination of the Bacillus anthracis Ames strain from the lungs in a rabbit model

Infection and Immunity

Volumn 75, Issue 7, 2007, Pages 3414-3424

  Peterson, Johnny W ^a   Comer, Jason E ^a   Baze, Wallace B ^b   Noffsinger, David M ^a   Wenglikowski, Autumn ^a   Walberg, Kristin G ^a   Hardcastle, Jason ^a   Pawlik, Jennifer ^a   Bush, Kathryn ^a   Taormina, Joanna ^a   Moen, Scott ^a   Thomas, John ^a   Chatuev, Bagram M ^a   Sower, Laurie ^a   Chopra, Ashok K ^a   Stanberry, Lawrence R ^a   Sawada, Ritsuko ^c   Scholz, Wolfgang W ^c   Sircar, Jagadish ^c  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c AVANIR PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVP 21D9; BACTERIAL ANTIGEN; HUMAN MONOCLONAL ANTIBODY; PROTECTIVE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHRAX; ANTIBODY TITER; ARTICLE; BACILLUS ANTHRACIS; BACTEREMIA; BACTERIAL COLONIZATION; BACTERIAL SPORE; BACTERIAL STRAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; HISTOPATHOLOGY; INHALATION; LUNG EDEMA; LUNG HEMORRHAGE; LUNG INFECTION; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; RABBIT; SINGLE DRUG DOSE; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ANIMALS; ANTHRAX; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; DISEASE MODELS, ANIMAL; HUMANS; LUNG; RABBITS; SPORES, BACTERIAL;

EID: 34447258679     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00352-07     Document Type: Article

References (31)

1. Abramova, F. A., L. M. Grinberg, O. V. Yampolskaya, and D. H. Walker. 1993. Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979. Proc. Natl. Acad. Sci. USA 90:2291-2294.
2. Agrawal, A., J. Lingappa, S. H. Leppla, S. Agrawal, A. Jabbar, C. Quinn, and B. Pulendran. 2003. Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature 424:329-334.
3. Brey, R. N. 2005. Molecular basis for improved anthrax vaccines. Adv. Drug Deliv. Rev. 57:1266-1292.
4. Centers for Disease Control and Prevention. 2001. CDC update: adverse events associated with anthrax prophylaxis among postal employees - New Jersey, New York City, and the District of Columbia metropolitan area.Morb. Mortal. Wkly. Rep. 50:1051-1054.
5. Comer, J. E., A. K. Chopra, J. W. Peterson, and R. Konig. 2005. Direct inhibition of T-lymphocyte activation by anthrax toxins in vivo. Infect. Immun. 73:8275-8281.
6. Comer, J. E., D. M. Noffsinger, D. J. McHenry, D. M. Weisbaum, B. M. Chatuev, A. K. Chopra, and J. W. Peterson. 2006. Evaluation of the protective effects of quinacrine against Bacillus anthracis Ames. J. Toxicol. Environ. Health A 69:1083-1095.
7. Cote, C. K., C. A. Rossi, A. S. Kang, P. R. Morrow, J. S. Lee, and S. L. Welkos. 2005. The detection of protective antigen (PA) associated with spores of Bacillus anthracis and the effects of anti-PA antibodies on spore germination and macrophage interactions. Microb. Pathog. 38:209-225.
8. Cote, C. K., N. Van Rooijen, and S. L. Welkos. 2006. Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection. Infect. Immun. 74:469-480.
9. Flick-Smith, H. C., N. J. Walker, P. Gibson, H. Bullifent, S. Hayward, J. Miller, R. W. Titball, and E. D. Williamson. 2002. A recombinant carboxyterminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection. Infect. Immun. 70:1653-1656.
10. Garmory, H. S., R. W. Titball, K. F. Griffin, U. Hahn, R. Bohm, and W. Beyer. 2003. Salmonella enterica serovar Typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge. Infect. Immun. 71:3831-3836.
11. Grinberg, L. M., F. A. Abramova, O. V. Yampolskaya, D. H. Walker, and J. H. Smith. 2001. Quantitative pathology of inhalational anthrax. I. Quantitative microscopic findings. Mod. Pathol. 14:482-495.
12. Guarner, J., J. A. Jernigan, W. J. Shieh, K. Tatti, L. M. Flannagan, D. S. Stephens, T. Popovic, D. A. Ashford, B. A. Perkins, and S. R. Zaki. 2003. Pathology and pathogenesis of bioterrorism-related inhalational anthrax. Am. J. Pathol. 163:701-709.
13. Hamouda, T., A. Y. Shih, and J. R. Baker. 2002. A rapid staining technique for the detection of the initiation of germination of bacterial spores. Lett. Microbiol. 34:86-90.
14. Heninger, S., M. Drysdale, J. Lovchik, J. Hutt, M. F. Lipscomb, T. M. Koehler, and C. R. Lyons. 2006. Toxin-deficient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax. Infect. Immun. 74:6067-6074.
15. Iacono-Connors, L. C., S. L. Welkos, B. E. Ivins, and J. M. Dalrymple. 1991. Protection against anthrax with recombinant virus-expressed protective antigen in experimental animals. Infect. Immun. 59:1961-1965.
16. Ivins, B. E., S. L. Welkos, S. F. Little, M. H. Crumrine, and G. O. Nelson. 1992. Immunization against anthrax with Bacillus anthracis protective antigen combined with adjuvants. Infect. Immun. 60:662-668.
17. Kobiler, D., S. Weiss, H. Levy, M. Fisher, A. Mechaly, A. Pass, and Z. Altboum. 2006. Protective antigen as a correlative marker for anthrax in animal models. Infect. Immun. 74:5871-5876.
18. Little, S. F., B. E. Ivins, W. M. Webster, P. F. Fellows, M. L. Pitt, S. L. Norris, and G. P. Andrews. 2006. Duration of protection of rabbits after vaccination with Bacillus anthracis recombinant protective antigen vaccine. Vaccine 24: 2530-2536.
19. Melnyk, R. A., and R. J. Collier. 2006. A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proc. Natl. Acad. Sci. USA 103:9802-9807.
20. O'Brien, J. A. Friedlander, T. Dreier, J. Ezzell, and S. Leppla. 1985. Effects of anthrax toxin components on human neutrophils. Infect. Immun. 47:306-310.
21. Peterson, J. W., J. E. Comer, D. M. Noffsinger, A. Wenglikowski, K. G. Walberg, B. M. Chatuev, A. K. Chopra, L. R. Stanberry, A. S. Kang, W. W. Scholz, and J. Sircar. 2006. Human monoclonal anti-protective antigen antibody completely protects rabbits and is synergistic with ciprofloxacin in protecting mice and guinea pigs against inhalation anthrax. Infect. Immun. 74:1016-1024.
22. Pitt, M. L. M., S. F. Little, B. E. Ivins, P. Fellows, J. Barth, J. Hewetson, P. Gibbs, M. Dertzbaugh, and A. M. Friedlander. 2001. In vitro correlate of immunity in a rabbit model of inhalational anthrax. Vaccine 19:4768-4773.
23. Rainey, G. J., D. J. Wigelsworth, P. L. Ryan, H. M. Scobie, R. J. Collier, and J. A. Young. 2005. Receptor-specific requirements for anthrax toxin delivery into cells. Proc. Natl. Acad. Sci. USA 102:13278-13283.
24. Roy, C. J., and L. M. L. Pitt. 2005. Infectious disease aerobiology: aerosol challenge methods. In J. L. Swearengen (ed.), Biodefense: research methodology and animal models. CRC Press, Boca Raton, FL.
25. Sawada-Hirai, R., I. Jiang, F. Wang, S. M. Sun, R. Nedellec, P. Ruther, A. Alvarez, D. Minis, P. R. Morrow, and A. S. Kang. 2004. Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed. J. Immune Based. Ther. Vaccines 2:5.
26. Varughese, M., A. V. Teixeira, S. Liu, and S. H. Leppla. 1999. Identification of a receptor-binding region within domain 4 of the protective antigen component of anthrax toxin. Infect. Immun. 67:1860-1865.
27. Wang, F., P. Ruther, I. Jiang, R. Sawada-Hirai, S. M. Sun, R. Nedellec, P. R. Morrow, and A. S. Kang. 2004. Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly. Hum. Antibodies 13:105- 110.
28. Weiss, S., D. Kobiler, H. Levy, H. Marcus, A. Pass, N. Rothschild, and Z. Altboum. 2006. Immunological correlates for protection against intranasal challenge of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits. Infect. Immun. 74:394-398.
29. Welkos, S. L., and A. M. Friedlander. 1988. Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice. Microb. Pathog. 5:127-139.
30. Williams, J. L., S. S. Noviello, K. S. Griffith, H. Wurtzel, J. Hamborsky, J. F. Perz, I. T. Williams, J. L. Hadler, D. L. Swerdlow, and R. Ridzon. 2002. Anthrax postexposure prophylaxis in postal workers, Connecticut, 2001. Emerg. Infect. Dis. 8:1133-1.137.
31. Zaucha, G. M., L. M. Pitt, J. Estep, B. E. Ivins, and A. M. Friedlander. 1998. The pathology of experimental anthrax in rabbits exposed by inhalation and subcutaneous inoculation. Arch. Pathol. Lab. Med. 122:982-992.