Assignment of backbone 1H, 13C and 15N resonances of human IgG1 Fc (51.4 kDa)

Biomolecular NMR Assignments

Volumn 1, Issue 2, 2007, Pages 233-235

  Liu, Dingjiang ^a   Cocco, Melanie J ^b   Rosenfied, Robert ^a   Lewis, Jeffery K ^a   Ren, Da ^a   Li, Luke ^a   Remmele Jr , Richard L ^a   Brems, David N ^a  

^a AMGEN INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibody; Fc region; IgG1; NMR assignment

Indexed keywords

ESCHERICHIA COLI;

CARBON; CARRIER PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; NITROGEN; PROLACTIN BINDING PROTEIN; PROLACTIN-BINDING PROTEIN; PROTON;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; HUMAN; METHODOLOGY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; CARBON ISOTOPES; CARRIER PROTEINS; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR WEIGHT; NITROGEN ISOTOPES; PROTEIN STRUCTURE, TERTIARY; PROTONS;

EID: 42949127961     PISSN: 18742718     EISSN: 1874270X     Source Type: Journal    
DOI: 10.1007/s12104-007-9065-5     Document Type: Article

References (10)

1. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A (1995) NMRPipe: A multidimensional spectral processing system based on UNIX pipes. J biomol NMR 6:277-293
2. Johnson BA (2004) Using NMR view to visualize and analyze the NMR spectra of macromolecules. Methods Mol Biol 278: 313-352
3. Kabat EA, Wu TT, Perry HM, Gottesmann KS, and Foeller C (1991) Sequences of proteins of immunological interest, 5th edn. NIH Publication no. 91-3242 U.S. Department of Health and Human Services
4. Kamei DT, Speed Ricci M, Deshpande R, Xu H, Lauffenburger DA (2004) Quantitative analysis of Fc ligand recycling kinetics. Biotechnol Bioeng 92:748-760
5. Krapp S, Mimura Y, Jefferis R, Huber R, Sondermann P (2003) Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity. J Mol Biol 325:979-989 (Pubitemid 36263407)
6. 15N resonances of the reduced human IgG1 CH3 domain. Biomol NMR Assignments 1:93-94
7. Nichol JL (2006) AMG 531: An investigational thrombopoiesisstimulating peptibody. Pediatr Blood Cancer 47:723-725 (Pubitemid 44360041)
8. Rice L (2006) Drug evaluation: AMG-531 for the treatment of thrombocytopenias. Curr Opin Investig Drugs 7:834-841 (Pubitemid 44382790)
9. Salzmann M, Pervushin K, Wider G, Senn H, Wuthrich K (1998) TROSY in triple-resonance experiments: New perspectives for sequential NMR assignment of large proteins. Proc Natl Acad Sci USA 95:13585-13590 (Pubitemid 28523015)
10. Yamaguchi Y, Nishimura M, Nagano M, Yagi H, Sasakawa H, Uchida K, Shitara K, Kato K (2006) Glycoform-dependent conformational alteration of the Fc region of human immunoglobulin G1 as revealed by NMR spectroscopy. Biochim Biophys Acta 1760:693-700